| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M202671200 |
| P698 | PubMed publication ID | 12140282 |
| P2093 | author name string | Olivia M Pereira-Smith | |
| Andrei Seluanov | |||
| Vera Gorbunova | |||
| P2860 | cites work | Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling | Q22003910 |
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| Extension of life-span by introduction of telomerase into normal human cells | Q24336088 | ||
| DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts | Q24336806 | ||
| A biomarker that identifies senescent human cells in culture and in aging skin in vivo | Q24562644 | ||
| Telomere shortening and apoptosis in telomerase-inhibited human tumor cells | Q24598974 | ||
| Specific Association of Human Telomerase Activity with Immortal Cells and Cancer | Q27860801 | ||
| Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective | Q28185623 | ||
| Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture | Q28365604 | ||
| p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2 | Q28609749 | ||
| The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus | Q29619815 | ||
| Genetic analysis of indefinite division in human cells: identification of four complementation groups | Q33640611 | ||
| ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. | Q33887607 | ||
| Telomeres and telomerase: implications for cancer and aging | Q33928492 | ||
| Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor | Q33961286 | ||
| Role of p14(ARF) in replicative and induced senescence of human fibroblasts | Q34012414 | ||
| Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes | Q34106524 | ||
| Cellular responses to DNA damage | Q34192725 | ||
| Regulation of cellular senescence by p53. | Q34254621 | ||
| Stress, DNA damage and ageing -- an integrative approach | Q34280196 | ||
| Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions | Q35076939 | ||
| Senescence of human fibroblasts induced by oncogenic Raf. | Q35210205 | ||
| Stringent sequence requirements for the formation of human telomeres | Q35751600 | ||
| Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent | Q36562455 | ||
| Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death | Q36742412 | ||
| Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. | Q39457857 | ||
| Cellular sites of H2O2-induced damage and their protection by nitroxides | Q40807479 | ||
| Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts | Q40812808 | ||
| hTERT can function with rabbit telomerase RNA: regulation of gene expression and attenuation of apoptosis | Q40839809 | ||
| Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast | Q40896311 | ||
| Hydrogen peroxide-induced apoptosis and necrosis in human lung fibroblasts: protective roles of glutathione | Q40966659 | ||
| Absence of cancer-associated changes in human fibroblasts immortalized with telomerase | Q40978424 | ||
| Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication | Q41045031 | ||
| Chromosome healing: spontaneous and programmed de novo telomere formation by telomerase | Q41270223 | ||
| 22 Autoradiography | Q41459920 | ||
| Human endothelial cell life extension by telomerase expression | Q41688544 | ||
| Chromosome healing, telomere capture and mechanisms of radiation-induced chromosome breakage | Q41701216 | ||
| Molecular aspects of the relationship between cancer and aging: tumor suppressor activity during cellular senescence | Q41702987 | ||
| Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts | Q42815554 | ||
| Senescence-like changes induced by hydroxyurea in human diploid fibroblasts | Q43506894 | ||
| Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation | Q43703982 | ||
| Cell cycle regulation in H(2)O(2)-induced premature senescence of human diploid fibroblasts and regulatory control exerted by the papilloma virus E6 and E7 proteins | Q45739999 | ||
| Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen | Q48084448 | ||
| Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. | Q52974538 | ||
| Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts. | Q52992070 | ||
| Telomerase primer specificity and chromosome healing | Q59021421 | ||
| P433 | issue | 41 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 38540-38549 | |
| P577 | publication date | 2002-07-24 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis | |
| P478 | volume | 277 |
| Q33739906 | 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation |
| Q91769921 | A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites |
| Q97557558 | A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing |
| Q35886886 | AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. |
| Q37198593 | Actions of human telomerase beyond telomeres |
| Q40143407 | Amino-bisphosphonates decrease hTERT gene expression in breast cancer in vitro |
| Q40275746 | Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways. |
| Q39507507 | Baculoviral expression of telomerase in primary human fibroblasts to rejuvenate cells for tissue engineering |
| Q59809439 | Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non-Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death |
| Q39559082 | CDK4 and cyclin D1 allow human myogenic cells to recapture growth property without compromising differentiation potential |
| Q40255897 | Cigarette smoke induces cellular senescence |
| Q37069829 | Coevolution of telomerase activity and body mass in mammals: from mice to beavers |
| Q60644031 | Cognitive performance in survivors of breast cancer and markers of biological aging |
| Q34032642 | Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation |
| Q52033664 | Contribution of proliferation and DNA damage repair to alveolar epithelial type 2 cell recovery from hyperoxia. |
| Q33990112 | Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis. |
| Q64108674 | Cytoskeletal alteration modulates cancer cell invasion through RhoA-YAP signaling in stromal fibroblasts |
| Q40522862 | Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance. |
| Q39595139 | Development of a Sleeping Beauty-based telomerase gene delivery system for hepatocytes |
| Q37655930 | Dickkopf-1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis |
| Q41840373 | Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation |
| Q45160492 | Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide |
| Q34551540 | ES micro-environment enhances stemness and inhibits apoptosis in human limbal stem cells via the maintenance of telomerase activity |
| Q41144052 | Effect of TERT on the growth of fibrosarcoma via caspase-3, survivin and PKB |
| Q35841918 | Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans |
| Q62604419 | Effects of hTERT on metal ion-induced genomic instability |
| Q36980873 | Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells. |
| Q33593132 | Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress |
| Q34534464 | Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells |
| Q47837464 | GWAS of epigenetic aging rates in blood reveals a critical role for TERT. |
| Q35752214 | Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks |
| Q34086792 | Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor. |
| Q39787838 | Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. |
| Q40371754 | Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms |
| Q40209144 | Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts |
| Q36255511 | Immortalized cells as experimental models to study cancer. |
| Q35756152 | In search of "stemness". |
| Q35676409 | Increased hepatic telomerase activity in a rat model of iron overload: a role for altered thiol redox state? |
| Q40504176 | Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase |
| Q40140877 | Knocking down p53 with siRNA does not affect the overexpression of p21WAF-1 after exposure of IMR-90 hTERT fibroblasts to a sublethal concentration of H2O2 leading to premature senescence |
| Q34233162 | Mechanism of telomerase activation by v-Rel and its contribution to transformation |
| Q50131963 | Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review |
| Q40031281 | Mycosporine-like amino acids extracted from scallop (Patinopecten yessoensis) ovaries: UV protection and growth stimulation activities on human cells |
| Q28115978 | NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability |
| Q34278129 | Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability |
| Q37776792 | Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house |
| Q38300255 | Physiologically achievable concentrations of genistein enhance telomerase activity in prostate cancer cells via the activation of STAT3. |
| Q41406772 | Prdx6 retards senescence and restores trabecular meshwork cell health by regulating reactive oxygen species |
| Q36444277 | Premature senescence of endothelial cells: Methusaleh's dilemma |
| Q39885940 | Pro-senescent effect of hydrogen peroxide on cancer cells and its possible application to tumor suppression |
| Q40080304 | Protection from acute cellular injury using Sleeping Beauty mediated telomerase gene transfer |
| Q36661483 | Proteome alteration induced by hTERT transfection of human fibroblast cells |
| Q28752381 | Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite Motif Protein 29 as a survival factor |
| Q38330053 | Relief of p53-mediated telomerase suppression by p73. |
| Q37094001 | Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. |
| Q43289917 | Reversible differentiation of immortalized human bladder smooth muscle cells accompanied by actin bundle reorganization |
| Q36241753 | Role of mitochondrial translocation of telomerase in hepatocellular carcinoma cells with multidrug resistance |
| Q28240398 | Role of the PLA2-independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stress |
| Q35032227 | SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation |
| Q55215006 | Significance of cellular senescence in aging and cancer. |
| Q24296492 | Sirt1 modulates premature senescence-like phenotype in human endothelial cells |
| Q36844727 | Sirtuins, Cell Senescence, and Vascular Aging |
| Q28068732 | Small molecule compounds that induce cellular senescence |
| Q24558758 | Smurf2 up-regulation activates telomere-dependent senescence |
| Q34395718 | Stable cellular senescence is associated with persistent DDR activation |
| Q40590057 | Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span |
| Q37064796 | Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapy |
| Q52827047 | Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. |
| Q35928861 | TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. |
| Q36631585 | Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cells |
| Q38884691 | Telomerase reverse transcriptase expression protects transformed human cells against DNA-damaging agents, and increases tolerance to chromosomal instability |
| Q35124297 | Telomere Q-PNA-FISH--reliable results from stochastic signals |
| Q40537821 | Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress |
| Q38032836 | Telomere lengthening and other functions of telomerase. |
| Q60284646 | Telomeres, telomerase and the cancer cell: an introduction |
| Q35851312 | Telomeres, telomerase, and apoptosis. |
| Q36205234 | The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage |
| Q41498647 | The mitochondrial lncRNA ASncmtRNA-2 is induced in aging and replicative senescence in Endothelial Cells |
| Q37219336 | The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype |
| Q38512280 | Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telo |
| Q41829757 | Transcriptional regulation of the human telomerase reverse transcriptase: new insights |
| Q90288349 | Transient Mitomycin C-treatment of human corneal epithelial cells and fibroblasts alters cell migration, cytokine secretion, and matrix accumulation |
| Q37457502 | Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase |
| Q54109933 | Tumor Cell-Accelerated Senescence Is Associated With DNA-PKcs Status and Telomere Dysfunction Induced by Radiation. |
| Q33736728 | Tumor suppression by p53: making cells senescent |
| Q28262195 | Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy |
| Q39844637 | Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. |
| Q35618961 | When cells get stressed: an integrative view of cellular senescence |
| Q42479814 | hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells |
| Q40479122 | hTERT antagonizes p53-induced apoptosis independently of telomerase activity. |
| Q37795742 | p38MAPK in the Senescence of Human and Murine Fibroblasts |
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