Senescence in the aging process.

scientific article published on 25 July 2017

Senescence in the aging process. is …
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scholarly articleQ13442814

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P356DOI10.12688/F1000RESEARCH.10903.1
P932PMC publication ID5531163
P698PubMed publication ID28781767

P50authorElizabeth L OstlerQ57321170
Richard G.A. FaragherQ63388271
Alison WillowsQ80980281
P2093author name stringAnne McArdle
P2860cites workExtension of life-span by introduction of telomerase into normal human cellsQ24336088
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Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old ratsQ28385398
Senescent intimal foam cells are deleterious at all stages of atherosclerosisQ28595661
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblastsQ29618748
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Should we treat aging as a disease? The consequences and dangers of miscategorisation.Q30377435
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A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygenQ33532644
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A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and agingQ33848611
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factorsQ34045737
Mitochondria are required for pro-ageing features of the senescent phenotype.Q34046100
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.Q34046144
Hypoxia suppresses conversion from proliferative arrest to cellular senescenceQ34291377
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenariansQ34503839
Simvastatin suppresses breast cancer cell proliferation induced by senescent cellsQ34504829
Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assayQ34526096
Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotypeQ34528652
Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosisQ34613489
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locusQ34940029
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Replicative senescence and the art of countingQ35617912
Variation in the life-span of clones derived from human diploid cell strainsQ36196012
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory PhenotypeQ36568015
The gene responsible for Werner syndrome may be a cell division "counting" geneQ36740224
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiencyQ36996311
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiationQ37082277
Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespanQ37086921
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Long-term caloric restriction delays age-related decline in proliferation capacity of murine lens epithelial cells in vitro and in vivoQ73013084
Distinction between differentiation and senescence and the absence of increased apoptosis in human keratinocytes undergoing cellular aging in vitroQ73985525
Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in ratsQ83803005
Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuliQ37219543
ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.Q37219985
Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.Q37235609
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p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.Q38788371
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Raman and Infrared Spectroscopy Distinguishing Replicative Senescent from Proliferating Primary Human Fibroblast Cells by Detecting Spectral Differences Mainly Due to Biomolecular Alterations.Q38963792
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.Q39378063
A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescenceQ39904614
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Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage responseQ42018166
NF-κB inhibition delays DNA damage-induced senescence and aging in miceQ42220488
Inhibitory effects of resveratrol on MCP-1, IL-6, and IL-8 production in human coronary artery smooth muscle cellsQ42438255
Resveratrol protects against physical fatigue and improves exercise performance in mice.Q42711789
Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblastsQ42716214
Intramitotic variation in proliferative potential: stochastic events in cellular agingQ43508680
Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcificationQ43890491
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.Q44816904
Resveratrol protects cortical neurons against microglia-mediated neuroinflammationQ45468485
Rapamycin and the inhibition of the secretory phenotypeQ46422298
Cellular senescence occurred widespread to multiple selective sites in the fetal tissues and organs of miceQ48475029
A quantitative analysis of the aging of human glial cells in cultureQ48711099
Red Grape Skin Polyphenols Blunt Matrix Metalloproteinase-2 and -9 Activity and Expression in Cell Models of Vascular Inflammation: Protective Role in Degenerative and Inflammatory Diseases.Q50229564
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)1219
P577publication date2017-07-25
P1433published inF1000ResearchQ27701587
P1476titleSenescence in the aging process
P478volume6