The Smad3 linker region contains a transcriptional activation domain

scientific article

The Smad3 linker region contains a transcriptional activation domain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20041820
P932PMC publication ID1134763
P698PubMed publication ID15588252

P2093author name stringFang Liu
Guannan Wang
Isao Matsuura
Dongming He
Jianyin Long
P2860cites workThe MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factorsQ22253348
Structural basis of heteromeric smad protein assembly in TGF-beta signalingQ24302541
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivatorQ24324502
Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase IIQ24551154
Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)Q24630482
Crystal structure of a transcriptionally active Smad4 fragmentQ27621046
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
TGF-β signalling from cell membrane to nucleus through SMAD proteinsQ28131770
CBP/p300 in cell growth, transformation, and developmentQ28140313
The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domainQ28142707
Smad-dependent and Smad-independent pathways in TGF-beta family signallingQ28208250
A component of the ARC/Mediator complex required for TGF beta/Nodal signallingQ28217192
New insights into TGF-beta-Smad signallingQ28260517
Smads: transcriptional activators of TGF-beta responsesQ28292325
SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signallingQ28506547
Transcriptional control by the TGF-beta/Smad signaling systemQ29618985
A vector for expressing GAL4(1-147) fusions in mammalian cellsQ29620516
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic RasQ35193411
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activationQ35205960
Receptor-regulated Smads in TGF-beta signalingQ35212942
Ski and SnoN: negative regulators of TGF-beta signalingQ35756034
Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.Q35813575
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cellsQ36263679
TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding proteinQ36926151
The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signalingQ39597497
TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300Q40445183
Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivoQ40497387
TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regionsQ40522842
Role of p300, a transcriptional coactivator, in signalling of TGF-betaQ40835770
Repression of Smad4 transcriptional activity by SUMO modificationQ41828670
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4Q45345228
Cyclin-dependent kinases regulate the antiproliferative function of SmadsQ47229633
Physical and functional interaction of SMADs and p300/CBPQ64381971
Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcriptionQ73280041
P433issuePt 1
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)29-34
P577publication date2005-02-15
P1433published inBiochemical JournalQ864221
P1476titleThe Smad3 linker region contains a transcriptional activation domain
P478volume386

Reverse relations

cites work (P2860)
Q37338950A negative feedback control of transforming growth factor-beta signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204.
Q24815288Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein
Q35661029Cyclin-Dependent Kinase 4–Mediated Phosphorylation Inhibits Smad3 Activity in Cyclin D–Overexpressing Breast Cancer Cells
Q34624838Downstream signaling mechanism of the C-terminal activation domain of transcriptional coactivator CoCoA.
Q46623958Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling. [corrected].
Q24528159Linking Smads and transcriptional activation
Q54298655MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells
Q34593629Mechanisms of Activin-Stimulated FSH Synthesis: The Story of a Pig and a FOX1
Q39682469Multimodal Sensing Strategy Using pH Dependent Fluorescence Switchable System
Q35108229Regulation of chondroitin-4-sulfotransferase (CHST11) expression by opposing effects of arylsulfatase B on BMP4 and Wnt9A
Q51620108Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer.
Q37509215Serine-204 in the linker region of Smad3 mediates the collagen-I response to TGF-β in a cell phenotype-specific manner
Q38122890Smad phospho-isoforms direct context-dependent TGF-β signaling
Q35478946Smad phosphoisoform signaling specificity: the right place at the right time
Q35649316Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells
Q46891938Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation
Q39269242Smad3 linker phosphorylation attenuates Smad3 transcriptional activity and TGF-β1/Smad3-induced epithelial–mesenchymal transition in renal epithelial cells
Q26863522Smad3 phospho-isoform signaling in hepatitis C virus-related chronic liver diseases
Q38364223Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription
Q37410310TGF-beta signal transduction in chronic kidney disease
Q39883712Transforming growth factor-{beta}-inducible phosphorylation of Smad3
Q42066518c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3.

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