Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue

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Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue is …
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scholarly articleQ13442814

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P819ADS bibcode2009PLoSO...4.7347H
P356DOI10.1371/JOURNAL.PONE.0007347
P3181OpenCitations bibliographic resource ID5072172
P932PMC publication ID2754526
P698PubMed publication ID19812697
P5875ResearchGate publication ID26879523

P2093author name stringLuba Dankulich-Nagrudny
Andrew I Spielman
Douglas L Bayley
Joseph G Brand
Edmund A Pribitkin
Roy S Feldman
Taufiqul Huque
Beverly J Cowart
Scott A Mackler
P2860cites workThe receptors and cells for mammalian tasteQ22337248
A proton-gated cation channel involved in acid-sensingQ24329227
The cells and logic for mammalian sour taste detectionQ24675916
Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathwaysQ28208630
Amiloride-Insensitive Currents of the Acid-Sensing Ion Channel-2a (ASIC2a)/ASIC2b Heteromeric Sour-Taste Receptor ChannelQ28566738
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptorQ28592962
Protons activate the delta-subunit of the epithelial Na+ channel in humansQ34290232
The human taste receptor hTAS2R14 responds to a variety of different bitter compoundsQ34324650
Acid detection by taste receptor cellsQ34460278
Taste and smell perception in the elderly: effect of medications and diseaseQ34555676
Inflammation activates the interferon signaling pathways in taste bud cellsQ34583489
The ASICs: signaling molecules? Modulators?Q35209215
Cellular mechanisms involved in CO(2) and acid signaling in chemosensitive neuronsQ35938786
Proton currents through amiloride-sensitive Na channels in hamster taste cells. Role in acid transductionQ36435019
Role of P-glycoprotein in statin drug interactionsQ36634221
Taste receptors in the gastrointestinal tract. V. Acid sensing in the gastrointestinal tractQ36661313
Acid-sensing ion channels in sensory perception.Q36790381
Ethanol consumption and taste preferences in C57BL/6ByJ and 129/J miceQ36800702
Critical illness and changes in sensory perceptionQ36885102
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPsQ36913317
The chemistry and physiology of sour taste--a reviewQ36998016
Separate populations of receptor cells and presynaptic cells in mouse taste budsQ37017466
Breadth of tuning and taste coding in mammalian taste budsQ37029781
Prevalence and causes of severe taste loss in a chemosensory clinic populationQ43514778
Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillaeQ43823188
Analysis of cell lineage relationships in taste buds.Q44012248
Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste budsQ44894463
Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controlsQ46874773
Acid-sensing ion channel-2 is not necessary for sour taste in mice.Q47717676
H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channelsQ47754214
Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.Q54594881
Chapter 8 Acid Sensing Ionic ChannelsQ58162894
The effect of amitriptyline on growth of olfactory and cerebral neurons in vitroQ68020684
Histochemically demonstrable ATPase activity in the taste buds of the ratQ68549511
Relationships between taste and smell across the adult life spanQ69635346
Taste thresholds: quality specific variation with human agingQ70313460
Kinetics of the taste response to chemical stimulation: a theory of acid taste in manQ70442631
Human saliva and taste responses to acids varying in anions, titratable acidity, and pHQ71338868
Receptor that leaves a sour taste in the mouthQ77448188
Dysgeusia limited to sweet taste in myasthenia gravisQ81200765
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectageusiaQ606216
Sodium channel epithelial 1 subunit deltaQ21100849
sensory perception of sour tasteQ21102071
Acid sensing ion channel subunit 1Q21102075
Acid sensing ion channel subunit 2Q21102082
Acid sensing ion channel subunit 3Q21102111
Polycystin 1 like 3, transient receptor potential channel interactingQ21126827
Polycystin 2 like 1, transient receptor potential cation channelQ21126833
P304page(s)e7347
P577publication date2009-01-01
P1433published inPLOS OneQ564954
P1476titleSour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue
P478volume4