Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL

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Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.FEBSLET.2011.08.012
P932PMC publication ID7164028
P698PubMed publication ID21856303
P5875ResearchGate publication ID51585249

P50authorJosé A CarrodeguasQ57036044
Julian PardoQ59221412
P2093author name stringAlfredo Lagunas-Martínez
Angélica Ospina
P2860cites workMolecular characterization of mitochondrial apoptosis-inducing factorQ22001452
Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1Q22010752
Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimersQ24292693
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome cQ24309066
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosisQ24310597
A short Nur77-derived peptide converts Bcl-2 from a protector to a killerQ24319007
A transmembrane helix dimer: structure and implicationsQ27735013
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsQ28117928
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complexQ28185671
Two isoforms of PSAP/MTCH1 share two proapoptotic domains and multiple internal signals for import into the mitochondrial outer membraneQ28239032
Exposure of any of two proapoptotic domains of presenilin 1-associated protein/mitochondrial carrier homolog 1 on the surface of mitochondria is sufficient for induction of apoptosis in a Bax/Bak-independent mannerQ28274421
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membraneQ28580739
MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondriaQ28594262
Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifsQ28771361
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
Mitochondrial control of cell deathQ29617739
The Fas death factorQ29620461
Apoptogenic interactions of plasmalemmal type-1 VDAC and Aβ peptides via GxxxG motifs induce Alzheimer's disease - a basic model of apoptosis?Q30155609
The GxxxG motif: a framework for transmembrane helix-helix associationQ30839523
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.Q33276402
Bcl-XL inhibits membrane permeabilization by competing with Bax.Q33343021
Statistical characterization of the GxxxG glycine repeats in the flagellar biosynthesis protein FliH and its Type III secretion homologue YscLQ33431015
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosisQ33854131
Characterization of the GXXXG motif in the first transmembrane segment of Japanese encephalitis virus precursor membrane (prM) proteinQ33934111
The mitochondrial permeability transition poreQ34034610
Sequence specificity in the dimerization of transmembrane alpha-helicesQ34279030
Mutational analysis of the role of GXXXG motif in the function of human organic anion transporter 1 (hOAT1).Q34580122
Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replicationQ35077451
The BCL-2 family reunionQ35568029
The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner.Q35574660
Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifsQ35863914
The C-terminal transmembrane domain of Bcl-xL mediates changes in mitochondrial morphologyQ36259561
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranesQ36799170
Bcl-xL forms two distinct homodimers at non-ionic detergents: implications in the dimerization of Bcl-2 family proteinsQ38296400
The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residuesQ38338136
Amino-terminal hydrophobic region of Helicobacter pylori vacuolating cytotoxin (VacA) mediates transmembrane protein dimerization.Q39518483
Control of Bax homodimerization by its carboxyl terminus.Q40122436
Mutational analysis of ABCG2: role of the GXXXG motifQ40534113
During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondriaQ40554731
Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanismsQ40976477
Neurotransmitter release - four years of SNARE complexesQ41541527
Dimerisation of the Rhodobacter sphaeroides RC-LH1 photosynthetic complex is not facilitated by a GxxxG motif in the PufX polypeptideQ42963873
The single transmembrane domains of ErbB receptors self-associate in cell membranesQ43821697
Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxinQ44299992
The GxxxG motif of the transmembrane domain of subunit e is involved in the dimerization/oligomerization of the yeast ATP synthase complex in the mitochondrial membraneQ44402671
Transport-deficient Pit2 phosphate transporters still modify cell surface oligomers structure in response to inorganic phosphateQ44926872
Membrane promotes tBID interaction with BCL(XL).Q45815145
Two GxxxG-like motifs facilitate promiscuous interactions of the human ErbB transmembrane domainsQ46053700
The yeast F(1)F(0)-ATP synthase: analysis of the molecular organization of subunit g and the importance of a conserved GXXXG motifQ46484164
Mutational analysis of putative helix-helix interacting GxxxG-motifs and tryptophan residues in the two-peptide bacteriocin lactococcin G.Q46648531
Generation of monoclonal antibody recognized by the GXXXG motif (glycine zipper) of prion protein.Q51803094
Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.Q52081092
BCL-XL dimerization by three-dimensional domain swapping.Q53964467
A dimerization motif for transmembrane α–helicesQ54246480
Heat-Induced Dimerization of BCL-xLthrough α-Helix Swapping†Q57266759
A conserved membrane-spanning amino acid motif drives homomeric and supports heteromeric assembly of presynaptic SNARE proteinsQ73675955
Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranesQ74001282
Sequence-specific Dimerization of the Transmembrane Domain of the “BH3-only” Protein BNIP3 in Membranes and DetergentQ79130136
A trimerizing GxxxG motif is uniquely inserted in the severe acute respiratory syndrome (SARS) coronavirus spike protein transmembrane domainQ80280648
Structure assembly of Bcl-x(L) through alpha5-alpha5 and alpha6-alpha6 interhelix interactions in lipid membranesQ84569267
P433issue19
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
identical protein bindingQ14762994
BCL2 like 1Q21173156
P1104number of pages8
P304page(s)2935-2942
P577publication date2011-08-16
P1433published inFEBS LettersQ1388051
P1476titleProtein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL
P478volume585

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cites work (P2860)
Q36354413Acidic pH promotes oligomerization and membrane insertion of the BclXL apoptotic repressor
Q36231970Evidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail-Anchor Insertion at the Mitochondrial Outer Membrane
Q36997143Heat-induced fibrillation of BclXL apoptotic repressor
Q35712841Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressor
Q30155360Structure-based analysis of VDAC1: N-terminus location, translocation, channel gating and association with anti-apoptotic proteins.
Q40591457The N-terminal helix of Bcl-xL targets mitochondria
Q37211985VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia
Q36450079VDAC1: from structure to cancer therapy