Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle

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Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle is …
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scholarly articleQ13442814

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P356DOI10.1016/0092-8674(94)90361-1
P698PubMed publication ID8124722

P50authorJoseph L. GoldsteinQ271424
P2093author name stringM S Brown
R G Anderson
R K Pathak
C K Garcia
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferaseQ28131695
Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamateQ28622734
The 12-transmembrane helix transportersQ34728878
Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic miceQ36223333
Regulation of lactate metabolism in vivo.Q38631655
L-lactate transport in Ehrlich ascites-tumour cellsQ39101991
The mechanism of lactate transport in human erythrocytesQ39228813
Transport of lactate and other monocarboxylates across mammalian plasma membranesQ40897800
Reconstitution of the L-lactate carrier from rat and rabbit erythrocyte plasma membranesQ42046166
Identification and partial purification of the erythrocyte L-lactate transporterQ42114050
Substrate and inhibitor specificity of monocarboxylate transport into heart cells and erythrocytes. Further evidence for the existence of two distinct carriersQ42794898
Mechanism of the inhibition of cholesterol biosynthesis by 6-fluoromevalonateQ42849386
Lactate transport is mediated by a membrane-bound carrier in rat skeletal muscle sarcolemmal vesiclesQ46832886
Preferential uptake of lactate by the normal myocardium in dogs.Q51877687
Lactate transport by skeletal muscle sarcolemmal vesicles.Q52395931
A comparative microphotometric study of succinate dehydrogenase activity levels in type I, IIA and IIB fibres of mammalian and human muscles.Q53940113
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)865-73
P577publication date1994-03-11
P1433published inCellQ655814
P1476titleMolecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle
P478volume76

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Q28580055Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle
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Q24642366Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1
Q52339897Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate.
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Q43003295The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability
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Q34237222The monocarboxylate transporter family--Structure and functional characterization
Q24531840The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation
Q46075785The relationship between monocarboxylate transporters 1 and 4 expression in skeletal muscle and endurance performance in athletes
Q46414720The role of carbonic anhydrase in the recovery of skeletal muscle from anoxia
Q24319749The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity
Q28184983The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV
Q47995285Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue.
Q41789962Tissue distribution of basigin and monocarboxylate transporter 1 in the adult male mouse: a study using the wild-type and basigin gene knockout mice
Q36386100Training-induced changes in membrane transport proteins of human skeletal muscle
Q74308896Transcription of the yeast TNA1 gene is not only regulated by nicotinate but also by p-aminobenzoate
Q41640765Transepithelial SCFA gradients regulate polarized Na/H exchangers and pH microdomains in colonic epithelia.
Q85246550Transepithelial transport and intraepithelial metabolism of short-chain fatty acids (SCFA) in the porcine proximal colon are influenced by SCFA concentration and luminal pH
Q37256924Transport of carboxylic acids in yeasts
Q46224366Transpulmonary pyruvate kinetics.
Q34513382Tumor metabolism, cancer cell transporters, and microenvironmental resistance
Q36713248cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1.

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