Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling

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Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling is …
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scholarly articleQ13442814

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P356DOI10.1016/S0092-8674(94)90442-1
P698PubMed publication ID8087843

P50authorThomas C. SüdhofQ97270
P2093author name stringZhang JZ
Anderson RG
Davletov BA
P2860cites workMolecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycleQ24336279
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Measurement of protein using bicinchoninic acidQ26778491
SNAP receptors implicated in vesicle targeting and fusionQ28131653
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferaseQ28131695
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusionQ28255534
Receptors compete for adaptors found in plasma membrane coated pitsQ28283978
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase CQ28576253
Membrane fusion machinery: insights from synaptic proteinsQ28609209
Molecular dissection of the secretory pathwayQ29618201
Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junctionQ34207383
Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.Q34335407
Vesicle-mediated protein sortingQ35671061
Identification of three coated vesicle components as alpha- and beta-tubulin linked to a phosphorylated 50,000-dalton polypeptideQ36207447
Coat proteins isolated from clathrin coated vesicles can assemble into coated pitsQ36220642
Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic miceQ36223333
Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formationQ36233556
Purification and characterization of smooth muscle cell caveolaeQ36234345
Biochemical dissection of AP-1 recruitment onto Golgi membranes.Q36383269
Proteins of synaptic vesicles involved in exocytosis and membrane recyclingQ36494085
Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recyclingQ36531890
Synaptic transmission persists in synaptotagmin mutants of DrosophilaQ38469273
Assembly of the mannose-6-phosphate receptor into reconstituted clathrin coats.Q41418348
Targeting and mistargeting of plasma membrane adaptors in vitroQ41511613
Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formationQ41570746
The appendage domain of the AP-2 subunit is not required for assembly or invagination of clathrin-coated pitsQ42075246
Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagminQ43328836
A role for synaptotagmin (p65) in regulated exocytosisQ44977634
The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding proteinQ48268447
Interaction of synaptotagmin with the cytoplasmic domains of neurexinsQ48337903
Synaptotagmin: a calcium sensor on the synaptic vesicle surfaceQ48480063
Binding of synaptotagmin to the alpha-latrotoxin receptor implicates both in synaptic vesicle exocytosisQ48656598
Developmental properties of Shibire: a pleiotropic mutation affecting larval and adult locomotion and development.Q52321662
Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosisQ59072845
Sea urchin egg cortical granule exocytosis is followed by a burst of membrane retrieval via uptake into coated vesiclesQ70448267
Interaction of activated EGF receptors with coated pit adaptinsQ72858669
Dissecting clathrin-coated pitsQ75292653
P433issue5
P407language of work or nameEnglishQ1860
P1104number of pages10
P304page(s)751-760
P577publication date1994-09-01
P1433published inCellQ655814
P1476titleSynaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling
P478volume78

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cites work (P2860)
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Q47072128Drosophila synaptotagmin I null mutants survive to early adulthood
Q24596657Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation
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Q44823871Identification and characterization of a novel C2B splice variant of synaptotagmin I.
Q24563413Identification of a nonneuronal isoform of synaptotagmin
Q48066991Identification of a novel protein containing two C2 domains selectively expressed in the rat brain and kidney.
Q35851542In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting
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Q24336247Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes
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Q34669186Role of synaptotagmin in Ca2+-triggered exocytosis
Q33796427Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal.
Q33796836Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal.
Q24684442Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking
Q28280225S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro
Q28142705SCAMP1 function in endocytosis
Q37343812SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis
Q35582307SNARE proteins contribute to calcium cooperativity of synaptic transmission
Q28585094SV2B regulates synaptotagmin 1 by direct interaction
Q28139743SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms
Q74034559Searching for depolarization-induced genes that modulate synaptic plasticity and neurotrophin-induced genes that mediate neuronal differentiation
Q34156651Selective inhibition of adaptor complex-mediated vesiculation
Q73039072Selective photoaffinity labeling of the inositol polyphosphate binding C2B domains of synaptotagmins
Q35065820Signals involved in targeting membrane proteins to synaptic vesicles
Q28265474Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway
Q41734067Sorting out adaptors
Q24670373Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery
Q30327812Structural characterization of the C2 domain of novel protein kinase Cepsilon.
Q27620366Structure of the Janus-faced C2B domain of rabphilin
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Q41727850Sustained neurotransmitter release: new molecular clues
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Q39164408Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets
Q43344007Synaptic exocytosis and nervous system development impaired in Caenorhabditis elegans unc-13 mutants
Q38024048Synaptic vesicle endocytosis
Q41541520Synaptic vesicle endocytosis
Q34286893Synaptic vesicle endocytosis: calcium works overtime in the nerve terminal
Q33983958Synaptic vesicle pools
Q38150436Synaptic vesicle protein 2A: basic facts and role in synaptic function
Q28577663Synaptic vesicle recycling at CNS snapses without AP-2
Q40521363Synaptic vesicle recycling. The Ferrari of endocytosis?
Q28293468Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis
Q33644579Synaptic-like microvesicles in mammalian pinealocytes
Q45099773Synaptobrevin is essential for fast synaptic-vesicle endocytosis
Q83669847Synaptotagmin 1 is necessary for the Ca2+ dependence of clathrin-mediated endocytosis
Q37611626Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse
Q26269972Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling
Q73669992Synaptotagmin I and IV define distinct populations of neuronal transport vesicles
Q52009038Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.
Q38361812Synaptotagmin I increases the probability of vesicle fusion at low [Ca2+] in pituitary cells
Q46083214Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo
Q48027351Synaptotagmin I stabilizes synaptic vesicles via its C(2)A polylysine motif.
Q44969000Synaptotagmin I synchronizes transmitter release in mouse hippocampal neurons.
Q35192506Synaptotagmin I, a Ca2+ sensor for neurotransmitter release
Q30835321Synaptotagmin I-DeltaC2B. A novel synaptotagmin isoform with a single C2 domain in the bovine adrenal medulla
Q28587672Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse
Q36697997Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain
Q28572138Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis
Q28577830Synaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblasts
Q37693057Synaptotagmin promotes both vesicle fusion and recycling
Q40867065Synaptotagmin regulation of coated pit assembly
Q48345645Synaptotagmin-1- and Synaptotagmin-7-Dependent Fusion Mechanisms Target Synaptic Vesicles to Kinetically Distinct Endocytic Pathways.
Q28581207Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis
Q47192722Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology
Q44058592Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain
Q33949154Synaptotagmins in membrane traffic: which vesicles do the tagmins tag?
Q41118335Synaptotagmins: C2-domain proteins that regulate membrane traffic
Q34460901Synaptotagmins: why so many?
Q28565951Synthesis degradation, and subcellular localization of synaptotagmin IV, a neuronal immediate early gene product
Q33703242Tailoring uniform coats for synaptic vesicles during endocytosis.
Q24683251Targeting of protein kinase Calpha to caveolae
Q92765544Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network
Q33964137Temporal and spatial coordination of exocytosis and endocytosis.
Q24550559The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform
Q28582288The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis
Q52597582The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.
Q24674621The C2 domain calcium-binding motif: structural and functional diversity
Q24314678The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization
Q48871184The C2A domain of double C2 protein gamma contains a functional nuclear localization signal
Q44367824The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).
Q36328687The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis
Q57208763The Cytoplasmic Domain of Rat Synaptotagmin I Enhances Synaptic Transmission
Q36256170The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation
Q42835010The alternative translation of synaptotagmin 1 mediates the non-classical release of FGF1
Q30176073The amphiphysin family of proteins and their role in endocytosis at the synapse
Q72190998The appendage domain of alpha-adaptin is a high affinity binding site for dynamin
Q40580009The biochemistry of neurotransmitter secretion
Q42819354The cysteine residue responsible for the release of fibroblast growth factor-1 residues in a domain independent of the domain for phosphatidylserine binding
Q30615629The electrical network of maize root apex is gravity dependent
Q28568363The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding
Q38334219The extravesicular domain of synaptotagmin-1 is released with the latent fibroblast growth factor-1 homodimer in response to heat shock
Q37359993The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review).
Q28143292The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity
Q26768190The iTRAPs: Guardians of Synaptic Vesicle Cargo Retrieval During Endocytosis
Q36819946The mast cell: where endocytosis and regulated exocytosis meet
Q77304417The molecular characterization of transport vesicles
Q24616029The molecular physiology of activity-dependent bulk endocytosis of synaptic vesicles
Q51751503The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms.
Q42833929The precursor but not the mature form of IL1alpha blocks the release of FGF1 in response to heat shock
Q47072626The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin.
Q92598532The role of PDLIM1, a PDZ-LIM domain protein, at the ribbon synapses in the chicken retina
Q41531587The roles of NSF, SNAPs and SNAREs during membrane fusion
Q33968141The stoned locus of Drosophila melanogaster produces a dicistronic transcript and encodes two distinct polypeptides.
Q29620168The synaptic vesicle cycle: a cascade of protein-protein interactions
Q36294041The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.
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Q41060398WW domains
Q24563029WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome
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Q24337374β-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein

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