Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets

scientific article published in 2017

Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets is …
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scholarly articleQ13442814

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P356DOI10.1124/PR.116.013342
P932PMC publication ID5394918
P698PubMed publication ID28265000

P50authorEge T. KavalaliQ74886885
P2093author name stringYing C Li
P2860cites workSV2 mediates entry of tetanus neurotoxin into central neuronsQ21090499
Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmissionQ21562195
Amphiphysin, a novel protein associated with synaptic vesiclesQ24294744
The synaptic vesicle cycleQ24297813
Complexins: cytosolic proteins that regulate SNAP receptor functionQ24309091
Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"Q24309183
Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recyclingQ24311523
Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21Q24317479
Mutations in DNAJC5, encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosisQ24319132
LRRK2 regulates synaptic vesicle endocytosisQ24336523
The synucleinsQ24551013
The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetamQ24561949
De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathiesQ24563008
Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter releaseQ24601743
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter releaseQ24611697
Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at central neuronsQ24629314
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitroQ24629968
Membrane fusion: grappling with SNARE and SM proteinsQ24633113
Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)Q24655420
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunitQ24678549
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophreniaQ24678573
The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancerQ24680318
Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter releaseQ26269844
Neurotransmitter release: the last millisecond in the life of a synaptic vesicleQ26269845
Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypesQ26269851
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmissionQ26269879
Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanismQ26269899
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helixQ26269900
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous releaseQ26269916
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interactionQ26269921
Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recyclingQ26269972
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic PotentialQ26781422
Enhancement of asynchronous release from fast-spiking interneuron in human and rat epileptic neocortexQ27319486
A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful miceQ27346832
SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatasesQ27934132
Calcineurin: form and functionQ27934527
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndromeQ28117514
Rab GTPases as coordinators of vesicle trafficQ28131746
Synucleins are a novel class of substrates for G protein-coupled receptor kinasesQ28138274
Constitutive phosphorylation of the Parkinson's disease associated alpha-synucleinQ28141645
Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin IIQ28179222
Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle primingQ28188061
Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish populationQ28201930
SNARE function analyzed in synaptobrevin/VAMP knockout miceQ28203549
Synaptotagmin I functions as a calcium regulator of release probabilityQ28204147
Alpha-synuclein and neurodegenerative diseasesQ28204386
Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorderQ28211166
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zoneQ28215837
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteinsQ28276992
Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.Q28281249
Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteinsQ28289561
Preferential involvement of excitatory neurons in medial temporal lobe in schizophreniaQ28291484
Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset ParkinsonismQ28293555
Binding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurementsQ28475132
Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2Q28482267
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle primingQ28504670
The calcium sensor synaptotagmin 7 is required for synaptic facilitationQ28505395
RIM1alpha is required for presynaptic long-term potentiationQ28508676
Distinct pools of synaptic vesicles in neurotransmitter releaseQ57649299
Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPaseQ57976151
Protein phosphorylation is required for endocytosis in nerve terminals: potential role for the dephosphins dynamin I and synaptojanin, but not AP180 or amphiphysinQ57976321
Subcellular localization of tetanus neurotoxin-insensitive vesicle-associated membrane protein (VAMP)/VAMP7 in neuronal cells: evidence for a novel membrane compartmentQ57979001
Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathwayQ57979066
Overexpression of synaptophysin enhances neurotransmitter secretion at Xenopus neuromuscular synapsesQ59616691
Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorderQ60440984
A radioassay for synaptic core complex assembly: Screening of herbal extracts for effectorsQ60716347
Mouse model of hyperkinesis implicates SNAP-25 in behavioral regulationQ71059970
Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranesQ73203897
Recombinant forms of tetanus toxin engineered for examining and exploiting neuronal trafficking pathwaysQ74009600
Nerve growth factor-induced phosphorylation of amphiphysin-1 by casein kinase 2 regulates clathrin-amphiphysin interactionsQ80196742
Long-distance retrograde effects of botulinum neurotoxin AQ81006671
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathiesQ81296212
Inhibition of SNARE-driven neuroexocytosis by plant extractsQ82680538
Different pools of postsynaptic GABAA receptors mediate inhibition evoked by low- and high-frequency presynaptic stimulation at hippocampal synapsesQ87544185
Single synapse evaluation of the postsynaptic NMDA receptors targeted by evoked and spontaneous neurotransmissionQ37490588
Ultrafast endocytosis at mouse hippocampal synapses.Q37642826
Amphiphysin I and regulation of synaptic vesicle endocytosisQ37662707
Synapsin II gene expression in the dorsolateral prefrontal cortex of brain specimens from patients with schizophrenia and bipolar disorder: effect of lifetime intake of antipsychotic drugsQ37676119
Kinetic efficiency of endocytosis at mammalian CNS synapses requires synaptotagmin IQ37692617
Ca2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1.Q37703486
Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders.Q37714086
Spontaneous neurotransmission: an independent pathway for neuronal signaling?Q37847816
α-Synuclein in Parkinson's diseaseQ37987146
Perspectives on kiss-and-run: role in exocytosis, endocytosis, and neurotransmissionQ38067906
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter releaseQ38166028
The mechanisms and functions of spontaneous neurotransmitter releaseQ38293976
Mutation analysis of SYNJ1: a possible candidate gene for chromosome 21q22-linked bipolar disorderQ38299200
Antisense in vivo knockdown of synaptotagmin I and synapsin I by HVJ-liposome mediated gene transfer modulates ischemic injury of hippocampus in opposing waysQ38356818
Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals.Q39226804
Development of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neuronsQ39340563
A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosisQ39752213
Asynchronous presynaptic glutamate release enhances neuronal excitability during the post-spike refractory period.Q40216542
Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles.Q40286914
SV2 is the protein receptor for botulinum neurotoxin A.Q40303506
Phosphorylation of dynamin I and synaptic-vesicle recyclingQ40394732
Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmissionQ40442647
Molecular mechanisms of clostridial neurotoxinsQ40642444
Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.Q40805470
Synaptotagmin regulation of coated pit assemblyQ40867065
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter releaseQ41017986
Beta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons.Q41437626
Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells.Q41483110
Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brainQ41483382
The kinetics of transmitter release at the frog neuromuscular junctionQ41512821
Synaptic vesicle endocytosisQ41541520
Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin.Q41712786
Vesicle recycling revisited: rapid endocytosis may be the first stepQ41720900
The multisubunit structure of synaptophysin. Relationship between disulfide bonding and homo-oligomerizationQ41733842
The role of non-canonical SNAREs in synaptic vesicle recyclingQ41829974
Truncations of amphiphysin I by calpain inhibit vesicle endocytosis during neural hyperexcitationQ41831888
Synthetic self-assembling clostridial chimera for modulation of sensory functionsQ41876523
α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasisQ41901772
Developing a PPI inhibitor-based therapy for STXBP1 haploinsufficiency-associated epileptic disordersQ41910332
v-SNARE composition distinguishes synaptic vesicle pools.Q42142233
Dopamine-D1 and -D2 receptors differentially regulate synapsin II expression in the rat brainQ42167604
Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.Q42274064
Fast, Temperature-Sensitive and Clathrin-Independent Endocytosis at Central SynapsesQ42362658
Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibitionQ42477784
A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapseQ42547280
Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model miceQ42586885
Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndromeQ42801227
Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter releaseQ42917089
The association of dynamin with synaptophysin regulates quantal size and duration of exocytotic events in chromaffin cells.Q42940256
Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses.Q43053624
Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.Q43100218
Asynchronous release of GABA via tonic cannabinoid receptor activation at identified interneuron synapses in rat CA1.Q43117339
UNC-13 is required for synaptic vesicle fusion in C. elegansQ43240851
Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmissionQ33661188
Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons.Q33712158
Synchronous and asynchronous transmitter release at nicotinic synapses are differentially regulated by postsynaptic PSD-95 proteinsQ33747790
Synucleins regulate the kinetics of synaptic vesicle endocytosis.Q33865356
AP-2 recruitment to synaptotagmin stimulated by tyrosine-based endocytic motifsQ33871607
Neurotoxins affecting neuroexocytosisQ33881286
Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3.Q33887879
Differential expression and distribution of alpha-, beta-, and gamma-synuclein in the developing human substantia nigraQ33938966
Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.Q33948657
Properties of synchronous and asynchronous release during pulse train depression in cultured hippocampal neuronsQ33949457
Anxiolytic-like effects of extracts from Albizzia julibrissin bark in the elevated plus-maze in ratsQ33982048
Synaptic vesicle poolsQ33983958
Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanismsQ34033326
SV2 acts via presynaptic calcium to regulate neurotransmitter release.Q34034957
A high-throughput screen to identify novel calcineurin inhibitorsQ34067826
Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junctionQ34068556
A trimeric protein complex functions as a synaptic chaperone machine.Q34093245
The SNAREs vti1a and vti1b have distinct localization and SNARE complex partnersQ34133588
Kinase-dependent Regulation of Monoamine Neurotransmitter TransportersQ34161514
Three modes of synaptic vesicular recycling revealed by single-vesicle imagingQ34203451
Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junctionQ34207383
Turnover of transmitter and synaptic vesicles at the frog neuromuscular junctionQ34207387
Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegansQ34239748
α-Synuclein knockout mice have cognitive impairments.Q34265318
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?Q34305507
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration.Q34314406
Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapseQ34321656
Short-term synaptic plasticity is altered in mice lacking synapsin I.Q34321716
Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channelsQ34321980
Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.Q34327884
Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recyclingQ34334008
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortexQ34355386
Different presynaptic roles of synapsins at excitatory and inhibitory synapses.Q34376922
Accumulation of α-synuclein triggered by presynaptic dysfunctionQ48273115
Phosphorylated synaphin/complexin found in the brain exhibits enhanced SNARE complex bindingQ48291901
A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.Q48352739
Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsyQ48369166
Protein kinase A-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activity.Q48375591
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregationQ48406052
Proteasome inhibition alleviates SNARE-dependent neurodegenerationQ48407910
Down-regulation synaptic vesicle protein 2A in the anterior temporal neocortex of patients with intractable epilepsy.Q48458333
Synaptotagmin: a calcium sensor on the synaptic vesicle surfaceQ48480063
Selective loss of synaptic proteins in Alzheimer's disease: evidence for an increased severity with APOE varepsilon4.Q48482230
Upregulated dynamin 1 in an acute seizure model and in epileptic patients.Q48484357
A novel STXBP1 mutation causes focal seizures with neonatal onsetQ48506471
Postnatal development of phase-locked high-fidelity synaptic transmission in the medial nucleus of the trapezoid body of the rat.Q48558660
Forskolin supresses seizures induced by pentylenetrazol in miceQ48601846
Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease.Q48650804
Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's diseaseQ48657276
Absence of TI-VAMP/Vamp7 leads to increased anxiety in miceQ48666076
Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's diseaseQ48882042
Alpha-synuclein binding to rab3a in multiple system atrophy.Q48912140
Synaptophysin gene expression in schizophrenia. Investigation of synaptic pathology in the cerebral cortexQ49080781
Serotonin transporter phosphorylation modulated by tetanus toxinQ49160079
Inhibitory transmission mediated by asynchronous transmitter release.Q50495483
Dramatic effect of levetiracetam in early-onset epileptic encephalopathy due to STXBP1 mutation.Q50577139
Botulinum neurotoxin A subtype 2 reduces pathological behaviors more effectively than subtype 1 in a rat Parkinson's disease model.Q50853892
Clinical spectrum of early-onset epileptic encephalopathies associated with STXBP1 mutations.Q51836559
Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.Q52508040
Reduced in vitro phosphorylation of synapsin I (site 1) in Alzheimer's disease postmortem tissuesQ53182572
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.Q54397791
Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.Q54901806
Neurotransmitter release: fusion or 'kiss-and-run'?Q55038012
Optical analysis of synaptic vesicle recycling at the frog neuromuscular junctionQ43552239
Fast kinetics of exocytosis revealed by simultaneous measurements of presynaptic capacitance and postsynaptic currents at a central synapseQ43601414
Down-regulation of synaptotagmin 1 in cortex, hippocampus, and cerebellum after experimental subarachnoid hemorrhageQ43643831
Synaptojanin 1 contributes to maintaining the stability of GABAergic transmission in primary cultures of cortical neurons.Q43805328
Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memoryQ43815520
Ca2+-dependent formation of a dynamin-synaptophysin complex: potential role in synaptic vesicle endocytosis.Q43847047
Fast vesicle recycling supports neurotransmission during sustained stimulation at hippocampal synapses.Q43906969
Transgenically encoded protein photoinactivation (FlAsH-FALI): acute inactivation of synaptotagmin I.Q44239529
Intraterminal Ca2+ concentration and asynchronous transmitter release at single GABAergic boutons in rat collicular culturesQ44364051
SNAP-25 reduction in the hippocampus of patients with schizophrenia.Q44400959
Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsyQ44416102
Early epileptic encephalopathies associated with STXBP1 mutations: Could we better delineate the phenotype?Q44639297
Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosisQ44693096
Competition between phasic and asynchronous release for recovered synaptic vesicles at developing hippocampal autaptic synapses.Q44728721
Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activityQ44736849
Synaptobrevin is essential for fast synaptic-vesicle endocytosisQ45099773
Altered expression of synaptic proteins occurs early during progression of Alzheimer's diseaseQ45172855
An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmissionQ45274254
Antiepileptic effects of botulinum neurotoxin E.Q45281121
Progressive depletion of complexin II in a transgenic mouse model of Huntington's diseaseQ45302047
Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease.Q45304640
Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6/2 Huntington's disease transgenic miceQ45306790
Phosphorylation and nitration of tyrosine residues affect functional properties of Synaptophysin and Dynamin I, two proteins involved in exo-endocytosis of synaptic vesiclesQ45374195
Botulinum neurotoxin A2 reduces incidence of seizures in mouse models of temporal lobe epilepsy.Q45913591
Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle.Q46032554
Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivoQ46083214
Rapid reuse of readily releasable pool vesicles at hippocampal synapsesQ46167177
Opposite changes in glutamatergic and GABAergic transmission underlie the diffuse hyperexcitability of synapsin I-deficient cortical networksQ46237364
Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis.Q46267461
Effect of chronic Albizzia julibrissin treatment on 5-hydroxytryptamine1A receptors in rat brainQ46490718
Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapseQ46699474
Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control studyQ46969020
Fast synaptic fatigue in shibire mutants reveals a rapid requirement for dynamin in synaptic vesicle membrane traffickingQ47070147
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growthQ47072408
Size of vesicle pools, rates of mobilization, and recycling at neuromuscular synapses of a Drosophila mutant, shibireQ47220778
Association between schizophrenia and the syntaxin 1A gene.Q47286205
Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.Q47867914
Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.Q47874870
Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminalsQ47889987
SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein familyQ47894520
A complete genetic analysis of neuronal Rab3 function.Q47952687
Behavioral abnormalities in synapsin II knockout mice implicate a causal factor in schizophreniaQ48021583
The role of Rab3A in neurotransmitter releaseQ48106348
Levetiracetam accelerates the onset of supply rate depression in synaptic vesicle trafficking.Q48114674
Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trialQ48130509
Integration of asynchronously released quanta prolongs the postsynaptic spike windowQ48130809
Excitotoxicity-related endocytosis in cortical neuronsQ48201186
Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.Q36212557
The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynaminQ36237077
Synaptic vesicles have two distinct recycling pathwaysQ36237608
Single-vesicle imaging reveals that synaptic vesicle exocytosis and endocytosis are coupled by a single stochastic modeQ36300120
Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosisQ36347832
Synaptic vesicle reuse and its implicationsQ36361004
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminalQ36455215
Dynamin, a membrane-remodelling GTPaseQ36460251
Action of botulinum neurotoxins in the central nervous system: antiepileptic effects.Q36511621
Synaptic vesicle generation from activity-dependent bulk endosomes requires calcium and calcineurin.Q36660705
α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.Q36685114
Synaptic vesicle endocytosis mediates the entry of tetanus neurotoxin into hippocampal neuronsQ36692413
Epileptic encephalopathy-causing mutations in DNM1 impair synaptic vesicle endocytosis.Q36766098
α-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayersQ36806739
Frequency-dependent modes of synaptic vesicle endocytosis and exocytosis at adult mouse neuromuscular junctionsQ36812971
Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic PlasticityQ36844167
Synaptic vesicle fusionQ36844178
Acute suppression of spontaneous neurotransmission drives synaptic potentiationQ36866368
Multiple vesicle recycling pathways in central synapses and their impact on neurotransmissionQ36906517
Vesicular neurotransmitter transporters as targets for endogenous and exogenous toxic substancesQ36947112
Ca(2+) and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal.Q36951925
Spontaneous and evoked glutamate release activates two populations of NMDA receptors with limited overlapQ36962792
Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's diseaseQ37013968
Dynamin phosphorylation controls optimization of endocytosis for brief action potential burstsQ37057969
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous systemQ37075340
Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington diseaseQ37083085
Neurodegenerative changes initiated by presynaptic dysfunctionQ37112980
X-linked intellectual disability-associated mutations in synaptophysin disrupt synaptobrevin II retrievalQ37128130
The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizuresQ37215037
Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmissionQ37341638
Synchronous and asynchronous modes of synaptic transmission utilize different calcium sourcesQ37405978
Voltage-gated potassium channels as therapeutic targetsQ37464784
Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampusQ37484739
The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosisQ34416249
Synapsins I and II are ATP-binding proteins with differential Ca2+ regulationQ34452467
Development of second-generation indole-based dynamin GTPase inhibitorsQ34483476
Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recyclingQ34568799
Integrating molecular and network biology to decode endocytosisQ34666235
Different dynamin blockers interfere with distinct phases of synaptic endocytosis during stimulation in motoneuronesQ34669847
DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortexQ34672850
Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors.Q34705504
Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesiclesQ34729313
Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmissionQ34911758
Differential regulation of spontaneous and evoked neurotransmitter release at central synapsesQ34975491
Detection of behavioral alterations and learning deficits in mice lacking synaptophysin.Q34977739
Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.Q34988000
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosisQ35058315
Desynchronization of multivesicular release enhances Purkinje cell outputQ35140624
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Q35210372
Development of quinone analogues as dynamin GTPase inhibitorsQ35217176
A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetamQ35217702
Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosisQ35281762
Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's diseaseQ35359220
Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cyclingQ35408613
Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsyQ35444901
Calcineurin regulation of neuronal plasticityQ35586583
Ca²⁺ influx slows single synaptic vesicle endocytosisQ35605344
1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activityQ35676521
Central effects of botulinum toxin type A: evidence and supposition.Q35693979
Endocytic pathway alterations in human hippocampus after global ischemia and the influence of APOE genotypeQ35748907
Botulinum toxin in clinical practiceQ35807826
Linking lipids to Alzheimer's disease: cholesterol and beyondQ35875480
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmissionQ35916627
Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic contextQ35950435
Two components of transmitter release at a central synapseQ36013914
Systematic review and metaanalysis of the efficacy of FK506 in experimental strokeQ36036681
Molecular underpinnings of synaptic vesicle pool heterogeneityQ36083087
Complexins regulate a late step in Ca2+-dependent neurotransmitter releaseQ31859100
Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia.Q33213888
An efficient drug delivery vehicle for botulism countermeasureQ33513008
Screening assay for small-molecule inhibitors of synaptojanin 1, a synaptic phosphoinositide phosphataseQ33561690
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progressionQ33639389
Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout miceQ28510217
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synucleinQ28511573
Essential role of phosphoinositide metabolism in synaptic vesicle recyclingQ28511682
Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neuronsQ28512527
SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter releaseQ28512897
Overlapping role of dynamin isoforms in synaptic vesicle endocytosisQ28513338
Development of a Fluorescent Quenching Based High Throughput Assay to Screen for Calcineurin InhibitorsQ28546525
SV2, a brain synaptic vesicle protein homologous to bacterial transportersQ28566808
Munc13-1 is required for presynaptic long-term potentiationQ28568366
The involvement of the small GTP-binding protein Rab5a in neuronal endocytosisQ28571235
Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteinsQ28574559
Rim is a putative Rab3 effector in regulating synaptic-vesicle fusionQ28575529
Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosisQ28580852
The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complexQ28581773
Essential functions of synapsins I and II in synaptic vesicle regulationQ28584865
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapseQ28587672
Alpha-synuclein cooperates with CSPalpha in preventing neurodegenerationQ28587785
Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout miceQ28590195
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosisQ28591459
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine systemQ28594502
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentQ29547294
Synaptic assembly of the brain in the absence of neurotransmitter secretionQ29618899
The synaptic vesicle cycle: a cascade of protein-protein interactionsQ29620168
Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and compositionQ30009070
Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosisQ30009567
Amphiphysin I is associated with coated endocytic intermediates and undergoes stimulation-dependent dephosphorylation in nerve terminalsQ30176331
Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactionsQ30176576
Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat.Q30405084
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responsesQ30471587
Anticonvulsant Activity of Extracts of Plectranthus barbatus Leaves in MiceQ30475019
Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neuronsQ30483551
The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticlesQ30488206
Presynaptic kainate receptor activation preserves asynchronous GABA release despite the reduction in synchronous release from hippocampal cholecystokinin interneuronsQ30496566
Identification of differentially expressed genes in rat hippocampus after transient global cerebral ischemia using subtractive cDNA cloning based on polymerase chain reactionQ30661014
Identification of SNARE complex modulators that inhibit exocytosis from an alpha-helix-constrained combinatorial libraryQ30960561
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)141-160
P577publication date2017-04-01
P1433published inPharmacological ReviewsQ2085079
P1476titleSynaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets
P478volume69

Reverse relations

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