scholarly article | Q13442814 |
P50 | author | Mitsunori Fukuda | Q48608809 |
Jun Aruga | Q56654368 | ||
P2093 | author name string | T Kojima | |
K Mikoshiba | |||
M Niinobe | |||
P2860 | cites work | The syntaxin family of vesicular transport receptors | Q24310598 |
A third synaptotagmin gene, Syt3, in the mouse | Q24564176 | ||
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold | Q27729921 | ||
Functional properties of multiple synaptotagmins in brain | Q28242788 | ||
Specificity and regulation of a synaptic vesicle docking complex | Q28246613 | ||
Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking | Q28249692 | ||
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C | Q28576253 | ||
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse | Q28587672 | ||
Differential expression of the p65 gene family | Q33602421 | ||
Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling | Q34334008 | ||
Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release. | Q34335407 | ||
Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein | Q34351277 | ||
The inositol high-polyphosphate series blocks synaptic transmission by preventing vesicular fusion: a squid giant synapse study. | Q36016838 | ||
Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue | Q36205409 | ||
Synaptic transmission persists in synaptotagmin mutants of Drosophila | Q38469273 | ||
Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin | Q43328836 | ||
A role for synaptotagmin (p65) in regulated exocytosis | Q44977634 | ||
Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis | Q59072845 | ||
P433 | issue | 44 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | mutational analysis | Q1955810 |
functional diversity | Q113242927 | ||
P1104 | number of pages | 5 | |
P304 | page(s) | 26523-26527 | |
P577 | publication date | 1995-11-01 | |
P1433 | published in | Journal of Biological Chemistry | Q867727 |
P1476 | title | Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain | |
P478 | volume | 270 |
Q28584924 | A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoforms |
Q48176012 | Alternative splicing in the first alpha-helical region of the Rab-binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution? |
Q24534201 | Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human |
Q28137740 | Alternative splicing of synaptotagmins involving transmembrane exon skipping |
Q82533435 | Analysis of the role of Rab27 effector Slp4-a/Granuphilin-a in dense-core vesicle exocytosis |
Q82533441 | Assay and functional interactions of Rim2 with Rab3 |
Q82533448 | Assay of the Rab-binding specificity of rabphilin and Noc2: target molecules for Rab27 |
Q41879755 | Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex |
Q74182014 | Axolemmal repair requires proteins that mediate synaptic vesicle fusion |
Q28186774 | Back in the water: the return of the inositol phosphates |
Q47313640 | Ca2+ releases E-Syt1 autoinhibition to couple ER-plasma membrane tethering with lipid transport. |
Q48320663 | Calcium-dependent oligomerization of synaptotagmins I and II. Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium |
Q36693214 | Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin |
Q35794843 | Cellular and molecular interactions of phosphoinositides and peripheral proteins |
Q37239601 | Cellular membranes and lipid-binding domains as attractive targets for drug development |
Q24532452 | Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII) |
Q24530221 | Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin |
Q33798205 | Coat proteins regulating membrane traffic. |
Q41837612 | Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family |
Q36137565 | Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release |
Q43195591 | Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs. |
Q37368223 | Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin |
Q28591477 | Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X |
Q24321337 | Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2 |
Q27764892 | Crystal structure of the C2 domain from protein kinase C-delta |
Q28577061 | Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin |
Q48799518 | Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS. |
Q24291404 | Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin |
Q24532479 | Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel |
Q28208436 | Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 |
Q35911352 | Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells. |
Q52164560 | Drosophila AD3 mutation of synaptotagmin impairs calcium-dependent self-oligomerization activity. |
Q44471204 | Endocytosis of synaptotagmin 1 is mediated by a novel, tryptophan-containing motif |
Q26269939 | Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+ |
Q38201382 | Exocytosis and synaptic vesicle function |
Q38297276 | Formation of crystalloid endoplasmic reticulum induced by expression of synaptotagmin lacking the conserved WHXL motif in the C terminus. Structural importance of the WHXL motif in the C2B domain |
Q43108400 | Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2. |
Q77770698 | Functional involvement of synaptotagmin I/II C2A domain in neurite outgrowth of chick dorsal root ganglion neuron |
Q24336821 | Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation |
Q24308862 | Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location |
Q24329129 | Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity |
Q28259174 | Identification of EPI64 as a GTPase-activating protein specific for Rab27A |
Q58120702 | Identification of Secretory Granule Phosphatidylinositol 4,5-Bisphosphate-interacting Proteins Using an Affinity Pulldown Strategy |
Q52530582 | Inositol 1,3,4,5-tetrakisphosphate binding activities of neuronal and non-neuronal synaptotagmins. Identification of conserved amino acid substitutions that abolish inositol 1,3,4,5-tetrakisphosphate binding to synaptotagmins III, V, and X. |
Q41110658 | Inositol phosphates - whither bound? Intracellular signalling. |
Q36377793 | Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance |
Q36125027 | Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis |
Q73203897 | Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes |
Q38300453 | Mechanism of the calcium-dependent multimerization of synaptotagmin VII mediated by its first and second C2 domains |
Q34296902 | Membrane targeting by C1 and C2 domains |
Q48881395 | Myelin proteolipid protein (PLP), but not DM-20, is an inositol hexakisphosphate-binding protein |
Q55038004 | PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane. |
Q45091416 | Patellin1, a novel Sec14-like protein, localizes to the cell plate and binds phosphoinositides |
Q28577400 | Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold |
Q51808788 | Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1. |
Q36301471 | Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits |
Q28506080 | Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV |
Q57362697 | Phospholipid-binding protein domains |
Q35553162 | Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1 |
Q34444317 | Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis. |
Q46419582 | Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules |
Q33750208 | Proteins involved in synaptic vesicle trafficking |
Q24337031 | PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex |
Q28117838 | RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes |
Q40492183 | Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes. |
Q36742238 | Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons |
Q28510077 | Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells |
Q42073768 | Regulation by bivalent cations of phospholipid binding to the C2A domain of synaptotagmin III. |
Q34669186 | Role of synaptotagmin in Ca2+-triggered exocytosis |
Q33652647 | Role of synaptotagmin, a Ca2+ and inositol polyphosphate binding protein, in neurotransmitter release and neurite outgrowth |
Q24684442 | Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking |
Q48232025 | Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells |
Q24300416 | Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity |
Q73039072 | Selective photoaffinity labeling of the inositol polyphosphate binding C2B domains of synaptotagmins |
Q28202672 | Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport |
Q28210017 | Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells |
Q48766938 | Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner |
Q36065276 | Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology |
Q37626108 | Stoned. |
Q41647854 | Structural and mechanistic features of phospholipases C: effectors of inositol phospholipid-mediated signal transduction |
Q27680751 | Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1 |
Q34047504 | Structure and function of clostridial phospholipases C. |
Q38300966 | Structure-function analyses of the small GTPase Rab35 and its effector protein centaurin-β2/ACAP2 during neurite outgrowth of PC12 cells. |
Q34606390 | Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes. |
Q38354357 | Structure-function relationships of the mouse Gap1m. Determination of the inositol 1,3,4,5-tetrakisphosphate-binding domain. |
Q47933649 | Synaptic function modulated by changes in the ratio of synaptotagmin I and IV. |
Q48027351 | Synaptotagmin I stabilizes synaptic vesicles via its C(2)A polylysine motif. |
Q28565285 | Synaptotagmin IV is present at the Golgi and distal parts of neurites |
Q34288288 | Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate |
Q34145357 | Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A. |
Q33949154 | Synaptotagmins in membrane traffic: which vesicles do the tagmins tag? |
Q36338049 | TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells |
Q28582288 | The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis |
Q24674621 | The C2 domain calcium-binding motif: structural and functional diversity |
Q44962988 | The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides |
Q24314678 | The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization |
Q48871184 | The C2A domain of double C2 protein gamma contains a functional nuclear localization signal |
Q38288586 | The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I. |
Q36328687 | The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis |
Q42577947 | The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate |
Q28364660 | The N-terminal cysteine cluster is essential for membrane targeting of B/K protein |
Q42323966 | The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes. |
Q42956567 | The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex. |
Q39791257 | The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes |
Q44009276 | The calcium-binding loops of the tandem C2 domains of synaptotagmin VII cooperatively mediate calcium-dependent oligomerization. |
Q33887543 | The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium. |
Q27637071 | Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine |
Q28505813 | Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes |
Q38288598 | Vesicle-associated membrane protein-2/synaptobrevin binding to synaptotagmin I promotes O-glycosylation of synaptotagmin I. |
Q33581675 | Vesicular reuptake inhibition by a synaptotagmin I C2B domain antibody at the squid giant synapse |
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