Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain.

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Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.270.44.26523
P698PubMed publication ID7592870
P5875ResearchGate publication ID15606010

P50authorMitsunori FukudaQ48608809
Jun ArugaQ56654368
P2093author name stringT Kojima
K Mikoshiba
M Niinobe
P2860cites workThe syntaxin family of vesicular transport receptorsQ24310598
A third synaptotagmin gene, Syt3, in the mouseQ24564176
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding foldQ27729921
Functional properties of multiple synaptotagmins in brainQ28242788
Specificity and regulation of a synaptic vesicle docking complexQ28246613
Protein-protein interactions contributing to the specificity of intracellular vesicular traffickingQ28249692
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase CQ28576253
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapseQ28587672
Differential expression of the p65 gene familyQ33602421
Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recyclingQ34334008
Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.Q34335407
Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion proteinQ34351277
The inositol high-polyphosphate series blocks synaptic transmission by preventing vesicular fusion: a squid giant synapse study.Q36016838
Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissueQ36205409
Synaptic transmission persists in synaptotagmin mutants of DrosophilaQ38469273
Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagminQ43328836
A role for synaptotagmin (p65) in regulated exocytosisQ44977634
Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosisQ59072845
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectmutational analysisQ1955810
functional diversityQ113242927
P1104number of pages5
P304page(s)26523-26527
P577publication date1995-11-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleFunctional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain
P478volume270

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cites work (P2860)
Q28584924A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoforms
Q48176012Alternative splicing in the first alpha-helical region of the Rab-binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution?
Q24534201Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human
Q28137740Alternative splicing of synaptotagmins involving transmembrane exon skipping
Q82533435Analysis of the role of Rab27 effector Slp4-a/Granuphilin-a in dense-core vesicle exocytosis
Q82533441Assay and functional interactions of Rim2 with Rab3
Q82533448Assay of the Rab-binding specificity of rabphilin and Noc2: target molecules for Rab27
Q41879755Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex
Q74182014Axolemmal repair requires proteins that mediate synaptic vesicle fusion
Q28186774Back in the water: the return of the inositol phosphates
Q47313640Ca2+ releases E-Syt1 autoinhibition to couple ER-plasma membrane tethering with lipid transport.
Q48320663Calcium-dependent oligomerization of synaptotagmins I and II. Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium
Q36693214Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin
Q35794843Cellular and molecular interactions of phosphoinositides and peripheral proteins
Q37239601Cellular membranes and lipid-binding domains as attractive targets for drug development
Q24532452Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)
Q24530221Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
Q33798205Coat proteins regulating membrane traffic.
Q41837612Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family
Q36137565Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release
Q43195591Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs.
Q37368223Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin
Q28591477Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X
Q24321337Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2
Q27764892Crystal structure of the C2 domain from protein kinase C-delta
Q28577061Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin
Q48799518Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS.
Q24291404Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin
Q24532479Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel
Q28208436Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2
Q35911352Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells.
Q52164560Drosophila AD3 mutation of synaptotagmin impairs calcium-dependent self-oligomerization activity.
Q44471204Endocytosis of synaptotagmin 1 is mediated by a novel, tryptophan-containing motif
Q26269939Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+
Q38201382Exocytosis and synaptic vesicle function
Q38297276Formation of crystalloid endoplasmic reticulum induced by expression of synaptotagmin lacking the conserved WHXL motif in the C terminus. Structural importance of the WHXL motif in the C2B domain
Q43108400Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2.
Q77770698Functional involvement of synaptotagmin I/II C2A domain in neurite outgrowth of chick dorsal root ganglion neuron
Q24336821Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation
Q24308862Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location
Q24329129Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity
Q28259174Identification of EPI64 as a GTPase-activating protein specific for Rab27A
Q58120702Identification of Secretory Granule Phosphatidylinositol 4,5-Bisphosphate-interacting Proteins Using an Affinity Pulldown Strategy
Q52530582Inositol 1,3,4,5-tetrakisphosphate binding activities of neuronal and non-neuronal synaptotagmins. Identification of conserved amino acid substitutions that abolish inositol 1,3,4,5-tetrakisphosphate binding to synaptotagmins III, V, and X.
Q41110658Inositol phosphates - whither bound? Intracellular signalling.
Q36377793Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance
Q36125027Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis
Q73203897Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes
Q38300453Mechanism of the calcium-dependent multimerization of synaptotagmin VII mediated by its first and second C2 domains
Q34296902Membrane targeting by C1 and C2 domains
Q48881395Myelin proteolipid protein (PLP), but not DM-20, is an inositol hexakisphosphate-binding protein
Q55038004PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.
Q45091416Patellin1, a novel Sec14-like protein, localizes to the cell plate and binds phosphoinositides
Q28577400Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold
Q51808788Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1.
Q36301471Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits
Q28506080Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV
Q57362697Phospholipid-binding protein domains
Q35553162Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1
Q34444317Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis.
Q46419582Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules
Q33750208Proteins involved in synaptic vesicle trafficking
Q24337031PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex
Q28117838RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes
Q40492183Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.
Q36742238Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons
Q28510077Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells
Q42073768Regulation by bivalent cations of phospholipid binding to the C2A domain of synaptotagmin III.
Q34669186Role of synaptotagmin in Ca2+-triggered exocytosis
Q33652647Role of synaptotagmin, a Ca2+ and inositol polyphosphate binding protein, in neurotransmitter release and neurite outgrowth
Q24684442Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking
Q48232025Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells
Q24300416Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity
Q73039072Selective photoaffinity labeling of the inositol polyphosphate binding C2B domains of synaptotagmins
Q28202672Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport
Q28210017Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells
Q48766938Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner
Q36065276Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology
Q37626108Stoned.
Q41647854Structural and mechanistic features of phospholipases C: effectors of inositol phospholipid-mediated signal transduction
Q27680751Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1
Q34047504Structure and function of clostridial phospholipases C.
Q38300966Structure-function analyses of the small GTPase Rab35 and its effector protein centaurin-β2/ACAP2 during neurite outgrowth of PC12 cells.
Q34606390Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes.
Q38354357Structure-function relationships of the mouse Gap1m. Determination of the inositol 1,3,4,5-tetrakisphosphate-binding domain.
Q47933649Synaptic function modulated by changes in the ratio of synaptotagmin I and IV.
Q48027351Synaptotagmin I stabilizes synaptic vesicles via its C(2)A polylysine motif.
Q28565285Synaptotagmin IV is present at the Golgi and distal parts of neurites
Q34288288Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate
Q34145357Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A.
Q33949154Synaptotagmins in membrane traffic: which vesicles do the tagmins tag?
Q36338049TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells
Q28582288The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis
Q24674621The C2 domain calcium-binding motif: structural and functional diversity
Q44962988The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides
Q24314678The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization
Q48871184The C2A domain of double C2 protein gamma contains a functional nuclear localization signal
Q38288586The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I.
Q36328687The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis
Q42577947The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate
Q28364660The N-terminal cysteine cluster is essential for membrane targeting of B/K protein
Q42323966The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.
Q42956567The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex.
Q39791257The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes
Q44009276The calcium-binding loops of the tandem C2 domains of synaptotagmin VII cooperatively mediate calcium-dependent oligomerization.
Q33887543The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.
Q27637071Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine
Q28505813Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes
Q38288598Vesicle-associated membrane protein-2/synaptobrevin binding to synaptotagmin I promotes O-glycosylation of synaptotagmin I.
Q33581675Vesicular reuptake inhibition by a synaptotagmin I C2B domain antibody at the squid giant synapse

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