RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes

scientific journal article

RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M115.684043
P932PMC publication ID4714225
P698PubMed publication ID26620560

P50authorMitsunori FukudaQ48608809
P2093author name stringNorihiko Ohbayashi
Hikaru Shimada
Soujiro Marubashi
P2860cites workOATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturationQ24295224
Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activityQ24300416
Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain.Q38289467
The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytesQ39791257
The GTPase-deficient Rab27A(Q78L) mutant inhibits melanosome transport in melanocytes through trapping of Rab27A effector protein Slac2-a/melanophilin in their cytosol: development of a novel melanosome-targetinG tag.Q39997500
Rab9A is required for delivery of cargo from recycling endosomes to melanosomesQ41788193
A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growthQ42820599
BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organellesQ24315003
RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteinsQ24318649
Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formationQ24336821
Melanosomes--dark organelles enlighten endosomal membrane transportQ24647195
Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cellsQ24673272
Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4Q24678933
BLOC-2 targets recycling endosomal tubules to melanosomes for cargo deliveryQ27310758
Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9Q28115891
BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factorQ28117259
Rab GTPases as coordinators of vesicle trafficQ28131746
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transportQ28202672
Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ERQ28206641
Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2Q28208436
Identification of EPI64 as a GTPase-activating protein specific for Rab27AQ28259174
Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytesQ28505813
The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome traffickingQ28507551
BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomesQ28513739
A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoformsQ28584924
Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and XQ28591477
Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2Q28592793
Syntaxin-3 is required for melanosomal localization of Tyrp1 in melanocytesQ28593492
Role of Rab GTPases in membrane traffic and cell physiologyQ29616548
TBC proteins: GAPs for mammalian small GTPase Rab?Q34159986
A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae.Q34461167
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.Q34549396
Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes.Q34606390
WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibitionQ34752403
The building BLOC(k)s of lysosomes and related organellesQ35840152
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymesQ36119125
Lysosome-related organelles: unusual compartments become mainstreamQ37060715
Regulation of secretory vesicle traffic by Rab small GTPasesQ37251862
Rab GEFs and GAPsQ37751479
Hermansky-Pudlak syndrome: pigmentary and non-pigmentary defects and their pathogenesisQ38061490
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectTyrosinaseQ14865361
Small G protein signaling modulator 2Q21134819
HPS4, biogenesis of lysosomal organelles complex 3 subunit 2Q21435910
RAB38, member RAS oncogene familyQ21498996
RAB9, member RAS oncogene familyQ21986377
Tyrosinase-related protein 1Q21987078
RAB32, member RAS oncogene familyQ21989991
Small G protein signaling modulator 2Q21990126
Dopachrome tautomeraseQ22677268
P304page(s)1427-1440
P577publication date2015-11-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleRUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes
P478volume291

Reverse relations

cites work (P2860)
Q92533083Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis
Q55032901In vitro gentamicin exposure alters caveolae protein profile in cochlear spiral ligament pericytes.
Q92763162Multiple Roles of Rab GTPases at the Golgi
Q28071741Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARP
Q52431395Neurodevelopmental Genetic Diseases Associated With Microdeletions and Microduplications of Chromosome 17p13.3.
Q38907192Rab proteins as regulators of lipid droplet formation and lipolysis
Q39254956Rab32 subfamily small GTPases: pleiotropic Rabs in endosomal trafficking
Q90639381Rab38 Mutation and the Lung Phenotype
Q90134711Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins
Q64945261Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.
Q36338049TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells
Q92147777The BLOC-3 subunit HPS4 is required for activation of Rab32/38 GTPases in melanogenesis, but its Rab9 activity is dispensable for melanogenesis

Search more.