Assay of the Rab-binding specificity of rabphilin and Noc2: target molecules for Rab27

scientific article published on 01 January 2005

Assay of the Rab-binding specificity of rabphilin and Noc2: target molecules for Rab27 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0076-6879(05)03041-7
P698PubMed publication ID16473612

P50authorMitsunori FukudaQ48608809
P2093author name stringAkitsugu Yamamoto
P2860cites workA complete genetic analysis of neuronal Rab3 function.Q47952687
Alternative splicing in the first alpha-helical region of the Rab-binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution?Q48176012
Involvement of rabphilin-3A in Ca2+-dependent exocytosis from PC12 cellsQ71009800
The C2 domains of Rabphilin3A specifically bind phosphatidylinositol 4,5-bisphosphate containing vesicles in a Ca2+-dependent manner. In vitro characteristics and possible significanceQ74465513
Comparison of the effects on secretion in chromaffin and PC12 cells of Rab3 family members and mutants. Evidence that inhibitory effects are independent of direct interaction with Rabphilin3Q77864017
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transportQ24295585
Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domainsQ24299097
Noc2, a putative zinc finger protein involved in exocytosis in endocrine cellsQ24336421
Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3AQ27639792
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transportQ28202672
Evolution of the Rab family of small GTP-binding proteinsQ28204091
Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteinsQ28204358
Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2Q28208436
Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cellsQ28210017
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domainQ28214394
Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cellsQ28510077
Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3CQ28571895
Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actinQ28584753
A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoformsQ28584924
Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and XQ28591477
Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domainQ28594490
pEF-BOS, a powerful mammalian expression vectorQ29547606
A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cellsQ33929508
Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cellsQ34144438
Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A.Q34145357
The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosisQ34273693
Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families.Q36043229
Rabphilin-3A: a multifunctional regulator of synaptic vesicle trafficQ36420115
Role of the Rab3A-binding domain in targeting of rabphilin-3A to vesicle membranes of PC12 cellsQ36562235
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagminQ36677635
Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain.Q38289467
Rab3A small GTP-binding protein in Ca(2+)-dependent exocytosisQ41392502
RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusionQ41733269
Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha -helix motifsQ43657454
Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3.Q43805353
P304page(s)469-481
P577publication date2005-01-01
P1433published inMethods in EnzymologyQ2076903
P1476titleAssay of the Rab-binding specificity of rabphilin and Noc2: target molecules for Rab27
P478volume403

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cites work (P2860)
Q30484362A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology
Q27012658Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors

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