Functional analysis of the C2A domain of synaptotagmin 1: implications for calcium-regulated secretion

scientific article published on 01 May 1998

Functional analysis of the C2A domain of synaptotagmin 1: implications for calcium-regulated secretion is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.18-10-03511.1998
P932PMC publication ID6793152
P698PubMed publication ID9570782

P2093author name stringD M Thomas
L A Elferink
P2860cites workTwo components of transmitter release at a central synapseQ36013914
Synaptic vesicle exocytosis: molecules and modelsQ40621455
Synaptotagmin and neurotransmitter releaseQ40713194
Synaptotagmins: C2-domain proteins that regulate membrane trafficQ41118335
Mode of action of alpha-latrotoxin: role of divalent cations in Ca2(+)-dependent and Ca2(+)-independent effects mediated by the toxinQ41712517
A role for synaptotagmin (p65) in regulated exocytosisQ44977634
Localization of synaptotagmin-binding domains on syntaxin.Q46864976
Interaction of synaptotagmin with the cytoplasmic domains of neurexinsQ48337903
Neurotransmitter release from synaptotagmin-deficient clonal variants of PC12 cellsQ48467769
Synaptotagmin: a calcium sensor on the synaptic vesicle surfaceQ48480063
A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerizationQ49061013
Distinct Ca(2+)-dependent properties of the first and second C2-domains of synaptotagmin I.Q49161795
Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.Q52508040
Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.Q55065913
Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosisQ59072845
Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase CQ71142569
Synaptotagmin is an inositol polyphosphate binding protein: isolation and characterization as an Ins 1,3,4,5-P4 binding proteinQ72362830
Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathwaysQ24299771
Doc2: a novel brain protein having two repeated C2-like domainsQ24309932
The syntaxin family of vesicular transport receptorsQ24310598
Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagminsQ24323300
Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding foldQ27729921
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferaseQ28131695
alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptorQ28242717
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid bindingQ28257052
Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switchQ28302242
The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ bindingQ28568363
Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptorsQ28570607
Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3CQ28571895
Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagminQ28574669
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase CQ28576253
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapseQ28587672
Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal.Q33796427
Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal.Q33796836
The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.Q33887543
Calcium dependence of the rate of exocytosis in a synaptic terminalQ34324078
Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recyclingQ34334008
Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.Q35871642
Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutantsQ35883796
Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells.Q35911352
P433issue10
P304page(s)3511-3520
P577publication date1998-05-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleFunctional analysis of the C2A domain of synaptotagmin 1: implications for calcium-regulated secretion
P478volume18

Reverse relations

cites work (P2860)
Q24532452Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)
Q36137565Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release
Q52164560Drosophila AD3 mutation of synaptotagmin impairs calcium-dependent self-oligomerization activity.
Q24647716Functional and biochemical analysis of the C2 domains of synaptotagmin IV
Q74034513Ion selectivities of the Ca(2+) sensors for exocytosis in rat phaeochromocytoma cells
Q34271469Plasma Membrane Disruption: Repair, Prevention, Adaptation
Q34444317Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis.
Q33750208Proteins involved in synaptic vesicle trafficking
Q35111679Risk of false positive genetic associations in complex traits with underlying population structure: a case study
Q24684442Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking
Q48027351Synaptotagmin I stabilizes synaptic vesicles via its C(2)A polylysine motif.
Q24675728The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi
Q51423998alpha-Latrotoxin releases calcium in frog motor nerve terminals.

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