| scholarly article | Q13442814 |
| P356 | DOI | 10.1126/SCIENCE.273.5272.248 |
| P698 | PubMed publication ID | 8662510 |
| P50 | author | Thomas C. Südhof | Q97270 |
| P2093 | author name string | X Shao | |
| B A Davletov | |||
| J Rizo | |||
| R B Sutton | |||
| P2860 | cites work | Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins | Q24323300 |
| Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold | Q27729921 | ||
| Functional properties of multiple synaptotagmins in brain | Q28242788 | ||
| Crystal structures of the helix-loop-helix calcium-binding proteins | Q28271755 | ||
| Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins | Q28289561 | ||
| A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP | Q28302244 | ||
| Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C | Q28576253 | ||
| Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse | Q28587672 | ||
| Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques | Q29614703 | ||
| The synaptic vesicle cycle: a cascade of protein-protein interactions | Q29620168 | ||
| Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C | Q29620247 | ||
| Protein structure determination in solution by two-dimensional and three-dimensional nuclear magnetic resonance spectroscopy | Q30421715 | ||
| Calcium dependence of the rate of exocytosis in a synaptic terminal | Q34324078 | ||
| Interaction of proteins with lipid headgroups: lessons from protein kinase C. | Q40832939 | ||
| Synaptotagmin: a calcium sensor on the synaptic vesicle surface | Q48480063 | ||
| Distinct Ca(2+)-dependent properties of the first and second C2-domains of synaptotagmin I. | Q49161795 | ||
| 1H and 15N resonance assignments and secondary structure of cellular retinoic acid-binding protein with and without bound ligand. | Q54021939 | ||
| P433 | issue | 5272 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 4 | |
| P304 | page(s) | 248-251 | |
| P577 | publication date | 1996-07-01 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C | |
| P478 | volume | 273 |
| Q30836188 | A calcium-inhibited Drosophila adenylyl cyclase |
| Q27642933 | A conformational switch in the Piccolo C2A domain regulated by alternative splicing |
| Q24532903 | A novel calcium-sensing domain in the BK channel |
| Q42147793 | A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release |
| Q44038198 | Additional binding sites for anionic phospholipids and calcium ions in the crystal structures of complexes of the C2 domain of protein kinase calpha. |
| Q28137740 | Alternative splicing of synaptotagmins involving transmembrane exon skipping |
| Q26269974 | An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release |
| Q37265752 | Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy |
| Q52528806 | Antisense suppression of phospholipase D alpha retards abscisic acid- and ethylene-promoted senescence of postharvest Arabidopsis leaves. |
| Q24685954 | Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb |
| Q54502571 | Arabidopsis synaptotagmin 1 is required for the maintenance of plasma membrane integrity and cell viability. |
| Q73924712 | Assignment of the 1H, 15N and 13C resonances of the calcium-free and calcium-bound forms of the first C2-domain of synaptotagmin I |
| Q26269957 | Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1 |
| Q28360864 | C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity |
| Q29619459 | C2-domains, structure and function of a universal Ca2+-binding domain |
| Q41541440 | Ca2+ and the regulation of neurotransmitter secretion |
| Q35213277 | Ca2+ binding alters the interdomain flexibility between the two cytoplasmic calcium-binding domains in the Na+/Ca2+ exchanger |
| Q24291150 | Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerization |
| Q26269956 | Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain? |
| Q42033626 | Ca2+ modulation of cis-unsaturated fatty acid-induced mutant protein kinase C activity: indication of inhibitory Ca2+-binding site in protein kinase C-alpha |
| Q27656957 | Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism |
| Q30359420 | Ca2+-binding motif of βγ-crystallins. |
| Q42917223 | Ca2+-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells |
| Q36595702 | Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission |
| Q26269884 | Calcium control of neurotransmitter release |
| Q35752790 | Calcium triggers an intramolecular association of the C2 domains in synaptotagmin |
| Q28278153 | Calcium-activated potassium channels |
| Q47828162 | Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically. |
| Q36693214 | Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin |
| Q24294673 | Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains |
| Q42076992 | Cation charge and size selectivity of the C2 domain of cytosolic phospholipase A(2) |
| Q33939988 | Cell wall integrity signaling in Saccharomyces cerevisiae |
| Q35794843 | Cellular and molecular interactions of phosphoinositides and peripheral proteins |
| Q37239601 | Cellular membranes and lipid-binding domains as attractive targets for drug development |
| Q24532452 | Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII) |
| Q24569595 | Characterization of soluble forms of nonchimeric type V adenylyl cyclases |
| Q82616680 | Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids |
| Q41837612 | Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family |
| Q24321337 | Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2 |
| Q27764892 | Crystal structure of the C2 domain from protein kinase C-delta |
| Q26269931 | Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution |
| Q39643220 | Crystallization and preliminary crystallographic analysis of a C2 protein from Arabidopsis thaliana. |
| Q24647160 | DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes |
| Q29618534 | Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis |
| Q42159002 | Determination of the calcium-binding sites of the C2 domain of protein kinase Calpha that are critical for its translocation to the plasma membrane |
| Q26269912 | Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release |
| Q73703938 | Distinct Ca2+ binding properties of novel C2 domains of plant phospholipase dalpha and beta |
| Q33906744 | Double C2 protein. A review. |
| Q45084937 | Dual roles of the C2B domain of synaptotagmin I in synchronizing Ca2+-dependent neurotransmitter release. |
| Q26799286 | Dynamics and Membrane Interactions of Protein Kinase C |
| Q34103383 | EF-hand calcium-binding proteins. |
| Q34110570 | Electrostatic control of the membrane targeting of C2 domains |
| Q36297895 | Enlightening molecular mechanisms through study of protein interactions |
| Q35123603 | Evolution, biochemistry and genetics of protein kinase C in fungi |
| Q24311812 | Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties |
| Q50034960 | Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release |
| Q38201382 | Exocytosis and synaptic vesicle function |
| Q74506578 | Functional analysis of the C2A domain of synaptotagmin 1: implications for calcium-regulated secretion |
| Q24647716 | Functional and biochemical analysis of the C2 domains of synaptotagmin IV |
| Q37013623 | Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release |
| Q26269936 | Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis |
| Q28186545 | Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7) |
| Q36276750 | Getting a grip on calcium regulation |
| Q28118077 | Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta |
| Q74047725 | Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2 |
| Q40943094 | Investigating the role played by protein-lipid and protein-protein interactions in the membrane association of the p120GAP CaLB domain |
| Q48051420 | Investigation of the Effect of Bilayer Composition on PKCα-C2 Domain Docking Using Molecular Dynamics Simulations. |
| Q37040469 | Isolation of a calcium-binding protein of the acrosomal membrane of bovine spermatozoa |
| Q24654170 | Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transduction |
| Q73203897 | Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes |
| Q77332922 | Lipid binding ridge on loops 2 and 3 of the C2A domain of synaptotagmin I as revealed by NMR spectroscopy |
| Q41737527 | Lymphocyte granule-mediated cell death. |
| Q54432027 | Mechanism of calcium gating in small-conductance calcium-activated potassium channels. |
| Q30473073 | Membrane domain formation by calcium-dependent, lipid-binding proteins: insights from the C2 motif |
| Q41740953 | Modulating protein kinase C signal transduction. |
| Q33698787 | Molecular and biochemical properties and physiological roles of plant phospholipase D. |
| Q39145271 | Molecular and enzymatic characterization of three phosphoinositide-specific phospholipase C isoforms from potato |
| Q42651233 | Molecular cloning and functional analysis of polyphosphoinositide-dependent phospholipase D, PLDbeta, from Arabidopsis |
| Q36888927 | Molecular heterogeneity of phospholipase D (PLD). Cloning of PLDgamma and regulation of plant PLDgamma, -beta, and -alpha by polyphosphoinositides and calcium |
| Q35198186 | Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening. |
| Q52565810 | Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila. |
| Q33896607 | Multiple forms of phospholipase D in plants: the gene family, catalytic and regulatory properties, and cellular functions |
| Q26269911 | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis |
| Q24310406 | N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression |
| Q38749071 | Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions |
| Q40119866 | Noncovalent keystone interactions controlling biomembrane structure |
| Q47373170 | Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses |
| Q27668029 | Pb 2+ as Modulator of Protein–Membrane Interactions |
| Q51808788 | Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1. |
| Q35125684 | Phospholipase A(2) isoforms: a perspective |
| Q57362697 | Phospholipid-binding protein domains |
| Q33850659 | Probing the determinants of diacylglycerol binding affinity in the C1B domain of protein kinase Cα. |
| Q41573478 | Protein kinase C and phospholipase C: bilayer interactions and regulation |
| Q34001808 | Protein kinase C is a calcium sensor for presynaptic short-term plasticity |
| Q30679049 | Protein kinase C-delta C2-like domain is a binding site for actin and enables actin redistribution in neutrophils |
| Q46419582 | Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules |
| Q35924279 | Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes |
| Q33598960 | Protein-protein interactions and protein modules in the control of neurotransmitter release |
| Q41990817 | Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin I |
| Q41733269 | RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion |
| Q42061701 | Real-time assay for monitoring membrane association of lipid-binding domains |
| Q42073768 | Regulation by bivalent cations of phospholipid binding to the C2A domain of synaptotagmin III. |
| Q34063787 | Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions |
| Q41382903 | Regulation of protein kinase C. |
| Q28831105 | Ring-like oligomers of Synaptotagmins and related C2 domain proteins |
| Q27933531 | Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. |
| Q43869321 | Role of electrostatic and hydrophobic interactions in Ca(2+)-dependent phospholipid binding by the C(2)A-domain from synaptotagmin I. |
| Q43000381 | Roles of calcium ions in the membrane binding of C2 domains. |
| Q35582307 | SNARE proteins contribute to calcium cooperativity of synaptic transmission |
| Q75247050 | Sculpting a domain by splicing |
| Q73039072 | Selective photoaffinity labeling of the inositol polyphosphate binding C2B domains of synaptotagmins |
| Q73206074 | Similarity between C2 domain jaws and immunoglobulin CDRs |
| Q24315872 | Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2 |
| Q27654558 | Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2 |
| Q26269910 | Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7 |
| Q26269950 | Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch |
| Q64992132 | Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin. |
| Q28566977 | Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4 |
| Q30327812 | Structural characterization of the C2 domain of novel protein kinase Cepsilon. |
| Q27680751 | Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1 |
| Q30176716 | Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead |
| Q24316485 | Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2 |
| Q37243184 | Structure and dynamics of Ca2+-binding domain 1 of the Na+/Ca2+ exchanger in the presence and in the absence of Ca2+ |
| Q34047504 | Structure and function of clostridial phospholipases C. |
| Q27648873 | Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association |
| Q27620366 | Structure of the Janus-faced C2B domain of rabphilin |
| Q27765101 | Structure of the key toxin in gas gangrene |
| Q27766029 | Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+ |
| Q36005265 | Synaptic vesicle docking: a putative role for the Munc18/Sec1 protein family |
| Q90002517 | Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin |
| Q36173880 | Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis |
| Q28204147 | Synaptotagmin I functions as a calcium regulator of release probability |
| Q74262689 | Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells |
| Q24299097 | Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains |
| Q28302242 | Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch |
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| Q34460901 | Synaptotagmins: why so many? |
| Q94653989 | Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis |
| Q54549081 | The Arabidopsis phospholipase D family. Characterization of a calcium-independent and phosphatidylcholine-selective PLD zeta 1 with distinct regulatory domains. |
| Q52597582 | The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo. |
| Q24674621 | The C2 domain calcium-binding motif: structural and functional diversity |
| Q73039506 | The C2 domain of protein kinase calpha is directly involved in the diacylglycerol-dependent binding of the C1 domain to the membrane |
| Q24314678 | The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization |
| Q38288586 | The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I. |
| Q42577947 | The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate |
| Q39211804 | The Extended-Synaptotagmins |
| Q36983031 | The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. |
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| Q38262070 | The molecular machinery of neurotransmitter release (Nobel lecture). |
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