Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis

scientific article published on 13 May 2020

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.54506
P932PMC publication ID7220375
P698PubMed publication ID32401194

P50authorManindra BeraQ85850389
James E RothmanQ87945906
Shyam S. KrishnakumarQ37372244
Sathish Kumar RamakrishnanQ39066660
P2093author name stringJeff Coleman
P2860cites workMembrane fusion: grappling with SNARE and SM proteinsQ24633113
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosisQ26269821
Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter releaseQ26269844
Neurotransmitter release: the last millisecond in the life of a synaptic vesicleQ26269845
Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypesQ26269851
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous releaseQ26269916
Three-dimensional structure of the complexin/SNARE complexQ27637702
Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain associationQ27648873
Complexin cross-links prefusion SNAREs into a zigzag arrayQ27670976
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitmentQ27678096
PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex AssemblyQ49383297
Fast vesicle fusion in living cells requires at least three SNARE complexesQ50541149
High throughput monitoring of single vesicle fusion using free-standing membranes and automated analysis.Q52563977
Mechanism of neurotransmitter release coming into focusQ57173506
SNARE machinery is optimized for ultrafast fusionQ61806540
Symmetrical organization of proteins under docked synaptic vesiclesQ64229653
Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.Q64952014
Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin.Q64992132
Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase CQ71142569
Molecular Mechanisms of Fast Neurotransmitter ReleaseQ88788901
Synergistic control of neurotransmitter release by different members of the synaptotagmin familyQ89052352
Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter releaseQ89517800
Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexinQ90002517
Synaptotagmin oligomers are necessary and can be sufficient to form a Ca2+ -sensitive fusion clampQ90661054
Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter ReleaseQ92168590
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding foldQ27729921
SNAP receptors implicated in vesicle targeting and fusionQ28131653
SNAREpins: minimal machinery for membrane fusionQ28131697
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusionQ28244016
Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidenticalQ28252426
Synaptic vesicles position complexin to block spontaneous fusionQ28284213
Complexin has opposite effects on two modes of synaptic vesicle fusionQ28302722
Alternative zippering as an on-off switch for SNARE-mediated fusionQ28307492
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapseQ28587672
Ring-like oligomers of Synaptotagmins and related C2 domain proteinsQ28831105
SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.Q30273692
Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivoQ33925872
Protein determinants of SNARE-mediated lipid mixingQ33999406
Calcium sensitive ring-like oligomers formed by synaptotagminQ34281080
Single reconstituted neuronal SNARE complexes zipper in three distinct stagesQ34294781
Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.Q34335407
Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapsesQ35180827
Controlling synaptotagmin activity by electrostatic screeningQ36300998
Evolutionary conservation of complexins: from choanoflagellates to miceQ36615769
Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic stateQ37078715
A Programmable DNA Origami Platform to Organize SNAREs for Membrane FusionQ37107629
Formation of Giant Unilamellar Proteo-Liposomes by Osmotic ShockQ37108998
Kinetic barriers to SNAREpin assembly in the regulation of membrane docking/priming and fusion.Q37281549
Conformational dynamics of calcium-triggered activation of fusion by synaptotagminQ37368223
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter releaseQ38166028
Chaperoning SNARE assembly and disassemblyQ38865222
Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I.Q42062226
The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosisQ46519419
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growthQ47072408
Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission.Q47139423
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neuronsQ48158587
Synaptotagmin: a calcium sensor on the synaptic vesicle surfaceQ48480063
P921main subjectexocytosisQ323426
P577publication date2020-05-13
P1433published ineLifeQ2000008
P1476titleSynergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
P478volume9

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cites work (P2860)
Q114113667Forces, Kinetics, and Fusion Efficiency Altered by the Full-Length Synaptotagmin-1 -PI(4,5)P2 Interaction in Constrained Geometries
Q98783246Signalling Pinpointed to the Tip: The Complex Regulatory Network That Allows Pollen Tube Growth
Q97589625Syntaxin Clustering and Optogenetic Control for Synaptic Membrane Fusion

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