Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission

scientific article published on January 2012

Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.4652-11.2012
P932PMC publication ID3567453
P698PubMed publication ID22279210

P50authorChantell S EvansQ86013286
Edwin ChapmanQ59541853
P2093author name stringZhao Wang
R Bryan Sutton
Laurie M Biela
Amelia R Striegel
Noreen E Reist
Jillian B Delehoy
P2860cites workBinding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapsesQ24671842
The C2 domain calcium-binding motif: structural and functional diversityQ24674621
Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter releaseQ26269912
Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?Q26269956
Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machineQ27637071
Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain associationQ27648873
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding foldQ27729921
Targeted gene expression as a means of altering cell fates and generating dominant phenotypesQ27861039
How synaptotagmin promotes membrane fusion.Q27863355
Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive mannerQ73918502
Lipid binding ridge on loops 2 and 3 of the C2A domain of synaptotagmin I as revealed by NMR spectroscopyQ77332922
Synaptotagmin I functions as a calcium regulator of release probabilityQ28204147
Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosisQ28204182
Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusionQ28584744
Position of synaptotagmin I at the membrane interface: cooperative interactions of tandem C2 domainsQ30441210
C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.Q34010567
Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1Q34093007
Electrostatic control of the membrane targeting of C2 domainsQ34110570
Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivoQ34171564
Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphateQ34288288
Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivoQ34974283
C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo.Q35190997
SNARE proteins contribute to calcium cooperativity of synaptic transmissionQ35582307
Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.Q35871642
Membrane binding and subcellular targeting of C2 domainsQ36582982
Synaptic transmission persists in synaptotagmin mutants of DrosophilaQ38469273
Co-operative action a calcium ions in transmitter release at the neuromuscular junctionQ41528052
Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.Q41791620
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter releaseQ42147793
Mutations in the second C2 domain of synaptotagmin disrupt synaptic transmission at Drosophila neuromuscular junctionsQ43645563
Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domainQ44058592
The synaptotagmin C2A domain is part of the calcium sensor controlling fast synaptic transmissionQ44520400
A role for synaptotagmin (p65) in regulated exocytosisQ44977634
External Ca2+ dependency of synaptic transmission in drosophila synaptotagmin I mutantsQ46630040
Drosophila synaptotagmin I null mutants survive to early adulthoodQ47072128
Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.Q47828162
Synaptotagmin I stabilizes synaptic vesicles via its C(2)A polylysine motif.Q48027351
A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.Q48352739
Synaptotagmin: a calcium sensor on the synaptic vesicle surfaceQ48480063
Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayersQ50524047
Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.Q52009038
Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.Q52508040
Neural specificity of elav expression: defining a Drosophila promoter for directing expression to the nervous system.Q52543806
Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.Q52565810
Drosophila synaptotagmin I null mutants show severe alterations in vesicle populations but calcium-binding motif mutants do not.Q52569216
The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.Q52597582
Nerve-evoked synchronous release and high K+ -induced quantal events are regulated separately by synaptotagmin I at Drosophila neuromuscular junctions.Q52673852
Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1Q58191235
Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase CQ71142569
Calcium-dependent transmitter secretion from fibroblasts: modulation by synaptotagmin IQ71712441
Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranesQ73203897
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectSynaptotagmin 1 Dmel_CG3139Q29812939
P304page(s)1253-1260
P577publication date2012-01-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleCalcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission
P478volume32

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cites work (P2860)
Q42513230A C1-C2 Module in Munc13 Inhibits Calcium-Dependent Neurotransmitter Release
Q30994945Analysis of shape and spatial interaction of synaptic vesicles using data from focused ion beam scanning electron microscopy (FIB-SEM).
Q38978762C2-domain containing calcium sensors in neuroendocrine secretion
Q35687725Calcium binding promotes conformational flexibility of the neuronal Ca(2+) sensor synaptotagmin
Q34281080Calcium sensitive ring-like oligomers formed by synaptotagmin
Q28281363Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity
Q38302250Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance ruler
Q21133645Differential roles for snapin and synaptotagmin in the synaptic vesicle cycle
Q41836213Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome.
Q41987606Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.
Q37013623Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release
Q57173506Mechanism of neurotransmitter release coming into focus
Q41853121Membrane Docking of the Synaptotagmin 7 C2A Domain: Electron Paramagnetic Resonance Measurements Show Contributions from Two Membrane Binding Loops.
Q33751347Neurexins.
Q38749071Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions
Q28831105Ring-like oligomers of Synaptotagmins and related C2 domain proteins
Q38086430Single Ca2+ channels and exocytosis at sensory synapses
Q64992132Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin.
Q27687169Structural basis of allosteric interactions among Ca2+-binding sites in a K+ channel RCK domain
Q41112044Synaptotagmin SYTA forms ER-plasma membrane junctions that are recruited to plasmodesmata for plant virus movement
Q100945927Synaptotagmin-1 membrane binding is driven by the C2B domain and assisted cooperatively by the C2A domain
Q47319293Targeting Phosphatidylserine with Calcium-Dependent Protein-Drug Conjugates for the Treatment of Cancer
Q34462217The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses
Q89594549The C2A domain of synaptotagmin is an essential component of the calcium sensor for synaptic transmission
Q62512847The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis
Q36558887The number and organization of Ca2+ channels in the active zone shapes neurotransmitter release from Schaffer collateral synapses
Q40736285The second C2-domain of copine-2, copine-6 and copine-7 is responsible for their calcium-dependent membrane association
Q27011779The structure and function of 'active zone material' at synapses
Q35594101The synaptotagmin juxtamembrane domain is involved in neuroexocytosis.
Q36132208Transmission, Development, and Plasticity of Synapses.

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