Calcium triggers an intramolecular association of the C2 domains in synaptotagmin

scientific article published on May 2000

Calcium triggers an intramolecular association of the C2 domains in synaptotagmin is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2000PNAS...97.5883G
P356DOI10.1073/PNAS.100127197
P932PMC publication ID18528
P698PubMed publication ID10811903
P5875ResearchGate publication ID12505758

P2093author name stringR A García
H A Godwin
C E Forde
P2860cites workDoc2: a novel brain protein having two repeated C2-like domainsQ24309932
Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2Q24315872
Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2Q24321337
Energy transfer: a spectroscopic rulerQ24618609
Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapsesQ24671842
The C2 domain calcium-binding motif: structural and functional diversityQ24674621
Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?Q26269956
Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interactionQ27620244
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding foldQ27729921
Crystal structure of a mammalian phosphoinositide-specific phospholipase C deltaQ27732615
A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1Q27734937
Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1AQ27765364
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolutionQ27765619
Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?Q27766047
Microdomains of high calcium concentration in a presynaptic terminalQ28182130
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid bindingQ28257052
Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switchQ28302242
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase CQ28576253
Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagminQ28577061
C2-domains, structure and function of a universal Ca2+-binding domainQ29619459
Calcium-dependent self-association of synaptotagmin I.Q30469377
Classification and evolution of EF-hand proteinsQ33587166
Structures of EF-hand Ca(2+)-binding proteins: diversity in the organization, packing and response to Ca2+ bindingQ33587170
Two components of transmitter release at a central synapseQ36013914
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagminQ36677635
Neural transmission. Synaptotagmin is just a calcium sensorQ40544540
Mutagenesis of the C2 domain of protein kinase C-alpha. Differential roles of Ca2+ ligands and membrane binding residuesQ41028602
Calcium binding and conformational response in EF-hand proteinsQ41145282
Distinct Ca2+ and Sr2+ binding properties of synaptotagmins. Definition of candidate Ca2+ sensors for the fast and slow components of neurotransmitter releaseQ41668416
Localization of synaptotagmin-binding domains on syntaxin.Q46864976
Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.Q47828162
Synaptotagmin: a calcium sensor on the synaptic vesicle surfaceQ48480063
A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerizationQ49061013
Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.Q52508040
Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.Q55065913
Membrane fusionQ67584890
Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase CQ71142569
Ca(2+)-dependent conformational change in synaptotagmin IQ72808828
Mechanism of phospholipid binding by the C2A-domain of synaptotagmin IQ77216937
Lipid binding ridge on loops 2 and 3 of the C2A domain of synaptotagmin I as revealed by NMR spectroscopyQ77332922
Mechanics of membrane fusionQ77448643
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)5883-5888
P577publication date2000-05-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleCalcium triggers an intramolecular association of the C2 domains in synaptotagmin
P478volume97

Reverse relations

cites work (P2860)
Q42147793A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release
Q42080174Biomolecular free energy profiles by a shooting/umbrella sampling protocol, "BOLAS"
Q34010567C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.
Q82616680Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids
Q30437821Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling
Q33200123High metal concentrations are required for self-association of synaptotagmin II.
Q33950706How does calcium trigger neurotransmitter release?
Q44130949Inositol hexakisphosphate (InsP6) can weaken the Ca(2+)-dependent membrane binding of C2AB domain of synaptotagmin I.
Q35089614Mechanism and function of synaptotagmin-mediated membrane apposition
Q34447415Negative coupling as a mechanism for signal propagation between C2 domains of synaptotagmin I.
Q37646168Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta's closing
Q47685834Phosphatidic acid-producing enzymes regulating the synaptic vesicle cycle: Role for PLD?
Q33922435Protein machines and lipid assemblies: current views of cell membrane fusion
Q34103402Protein-protein interactions in intracellular membrane fusion.
Q41990817Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin I
Q35621978SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors
Q30435374Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging
Q56591899Structural Basis for Possible Calcium-Induced Activation Mechanisms of Calpains
Q37243184Structure and dynamics of Ca2+-binding domain 1 of the Na+/Ca2+ exchanger in the presence and in the absence of Ca2+
Q58191235Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1
Q28204147Synaptotagmin I functions as a calcium regulator of release probability
Q33939019Synaptotagmin I is a molecular target for lead
Q28208303Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
Q52597582The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.
Q27637071Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine
Q34763458Visualization of synaptotagmin I oligomers assembled onto lipid monolayers.

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