SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis

scientific article published on September 1996

SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1996PNAS...9310471M
P356DOI10.1073/PNAS.93.19.10471
P932PMC publication ID38409
P698PubMed publication ID8816825
P5875ResearchGate publication ID14388127

P2093author name stringM C Wilson
E Battenberg
P P Mehta
P2860cites workOn the structure of the 'synaptosecretosome'. Evidence for a neurexin/synaptotagmin/syntaxin/Ca2+ channel complexQ48249293
Synaptosomes possess an exocytotic pool of glutamateQ48332236
Synaptotagmin: a calcium sensor on the synaptic vesicle surfaceQ48480063
Calcium-dependent release of accumulated glutamate from synaptic vesicles within permeabilized nerve terminals.Q52052318
The probability of transmitter release at a mammalian central synapse.Q52386844
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25Q57979097
A peptide that mimics the carboxy-terminal domain of SNAP-25 blocks Ca2+ -dependent exocytosis in chromaffin cellsQ58009259
Nonuniform probability of glutamate release at a hippocampal synapseQ58191305
Kinetic analysis of secretion from permeabilized adrenal chromaffin cells reveals distinct componentsQ68236621
Regulation of calcium in isolated nerve terminals (synaptosomes): relationship to neurotransmitter releaseQ69379000
Ca(2+)-dependent conformational change in synaptotagmin IQ72808828
A complex of rab3A, SNAP-25, VAMP/synaptobrevin-2 and syntaxins in brain presynaptic terminalsQ72911941
Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparationQ24681205
Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assemblyQ26269962
SNAP receptors implicated in vesicle targeting and fusionQ28131653
Mechanisms of intracellular protein transportQ28131681
Microdomains of high calcium concentration in a presynaptic terminalQ28182130
SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coilsQ28240829
A post-docking role for synaptobrevin in synaptic vesicle fusionQ28243803
Specificity and regulation of a synaptic vesicle docking complexQ28246613
Protein-protein interactions contributing to the specificity of intracellular vesicular traffickingQ28249692
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusionQ28255534
Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and EQ28609206
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bondsQ28609207
The synaptic vesicle cycle: a cascade of protein-protein interactionsQ29620168
Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neuronsQ30442277
Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusionQ34297685
Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recyclingQ34334008
Regulated vesicular fusion in neurons: snapping together the detailsQ35253430
The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulationsQ35617869
Neuronal Ca2+ signalling takes the local routeQ36376586
Resolution of regulated secretion into sequential MgATP-dependent and calcium-dependent stages mediated by distinct cytosolic proteinsQ36531961
Amino acid neurotransmission: spotlight on synaptic vesiclesQ36570724
Calcium action in synaptic transmitter releaseQ38173587
Calcium ions, active zones and synaptic transmitter releaseQ38201298
Membrane trafficking in the presynaptic nerve terminalQ40524461
Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca(2+)-dependent mannerQ40542920
Ca2+ and secretory-vesicle dynamicsQ40542924
Synaptic vesicle exocytosis: molecules and modelsQ40621455
Synaptotagmin and neurotransmitter releaseQ40713194
Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamateQ41278939
Secretion in AtT-20 cells stably transfected with soluble synaptotagminsQ41451429
Syntaxin and synaptobrevin function downstream of vesicle docking in DrosophilaQ41666993
Synaptic vesicle proteins and early endosomes in cultured hippocampal neurons: differential effects of Brefeldin A in axon and dendrites.Q41809757
A role for synaptotagmin (p65) in regulated exocytosisQ44977634
Localization of synaptotagmin-binding domains on syntaxin.Q46864976
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectexocytosisQ323426
neurotransmitterQ162657
P304page(s)10471-10476
P577publication date1996-09-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis
P478volume93

Reverse relations

cites work (P2860)
Q73009327A peptide that mimics the C-terminal sequence of SNAP-25 inhibits secretory vesicle docking in chromaffin cells
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Q44365874A search for synthetic peptides that inhibit soluble N-ethylmaleimide sensitive-factor attachment receptor-mediated membrane fusion
Q44154777Aberrant reduction of an inhibitory protein factor in a rat epileptic model
Q48251062Activity-dependent phosphorylation of SNAP-25 in hippocampal organotypic cultures
Q92210136Acute Functional Adaptations in Isolated Presynaptic Terminals Unveil Synaptosomal Learning and Memory
Q28137740Alternative splicing of synaptotagmins involving transmembrane exon skipping
Q24671842Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
Q36328525Biochemical and functional studies of cortical vesicle fusion: the SNARE complex and Ca2+ sensitivity
Q48320663Calcium-dependent oligomerization of synaptotagmins I and II. Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium
Q54311861Changes of synaptotagmin interaction with t-SNARE proteins in vitro after calcium/calmodulin-dependent phosphorylation.
Q42171463Chronic antidepressants induce redistribution and differential activation of alphaCaM kinase II between presynaptic compartments.
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Q35387949Development of functional units within trigeminal ganglia correlates with increased expression of proteins involved in neuron-glia interactions
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Q42440348Effect of low pH on glutamate uptake and release in isolated presynaptic endings from rat brain
Q48167766Effect of thyroxine on synaptotagmin 1 and SNAP-25 expression in dorsal hippocampus of adult-onset hypothyroid rats
Q42460396Effects of extracellular pH reductions on [(3)H]D-aspartate and [(3)H]noradrenaline release by presynaptic nerve terminals isolated from rat cerebral cortex
Q34673332Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats
Q57649281Erratum: Coupling calcium to SNARE–mediated synaptic vesicle fusion
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Q27933694Vam7p, a vacuolar SNAP-25 homolog, is required for SNARE complex integrity and vacuole docking and fusion

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