A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

scientific article (published 1996-01-15)

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases is …
instance of (P31):
scholarly articleQ13442814

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P3181OpenCitations bibliographic resource ID363577
P932PMC publication ID449944
P698PubMed publication ID8617204

P2093author name stringD Chilov
K Alitalo
K Pajusola
A Kaipainen
V Joukov
E Kukk
N Kalkkinen
O Saksela
I Lahtinen
P2860cites workCrystal structure of human platelet-derived growth factor BBQ24293538
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factorQ24294262
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell linesQ24299707
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formationQ24316945
Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinaseQ24318336
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factorQ24323249
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factorQ24328901
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factorQ24560244
'Touchdown' PCR to circumvent spurious priming during gene amplificationQ24630793
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
A new method for predicting signal sequence cleavage sitesQ27861117
The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptorQ28115309
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDRQ28238949
Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14Q28297843
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryoQ28586040
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endotheliumQ28587604
Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceQ28593600
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesisQ28594191
Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptorsQ28611479
Vascular endothelial growth factor is a secreted angiogenic mitogenQ28646475
Angiogenesis in cancer, vascular, rheumatoid and other diseaseQ29547165
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluidQ29617640
FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell linesQ30984508
Long-term culture of capillary endothelial cellsQ34038077
Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGFQ34235775
Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcriptsQ34306819
Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.Q34455428
The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.Q37625629
Endothelial receptor tyrosine kinases involved in angiogenesis.Q40400431
Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction.Q40402643
Differentiation of endothelium.Q40447467
Structure of platelet-derived growth factor: implications for functional propertiesQ40832545
Role of VEGF-flt receptor system in normal and tumor angiogenesis.Q40951691
Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.Q41481649
Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutantQ41488146
Enhanced secretion from insect cells of a foreign protein fused to the honeybee melittin signal peptideQ41695196
The Balbiani ring 3 gene in Chironomus tentans has a diverged repetitive structure split by many intronsQ41840020
Balbiani ring 3 in Chironomus tentans encodes a 185-kDa secretory protein which is synthesized throughout the fourth larval instarQ42633114
Identification and structural analysis of the A type receptor for platelet-derived growth factor. Similarities with the B type receptor.Q45933270
Molecular cloning of murine FLT and FLT4.Q48107458
Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesisQ48117290
Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutationsQ72372332
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
Vascular endothelial growth factor CQ7916457
positive regulation of cell population proliferationQ14633891
P304page(s)290-98
P577publication date1996-01-15
P1433published inThe EMBO JournalQ1278554
P1476titleA novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
P478volume15

Reverse relations

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Q24656802Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma
Q35187933Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy.
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