| scholarly article | Q13442814 |
| P50 | author | Alan R. Brash | Q21934160 |
| P2093 | author name string | Marcia E Newcomer | |
| David B Neau | |||
| Sue G Bartlett | |||
| William E Boeglin | |||
| Nathaniel C Gilbert | |||
| Maria T Waight | |||
| P2860 | cites work | Kinetic Studies of Oxygen Reactivity in Soybean Lipoxygenase-1 | Q43638675 |
| Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis | Q43713839 | ||
| Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog. | Q44429144 | ||
| Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Inactivation by H2O2 and inhibition by metal ions | Q45018357 | ||
| Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality | Q46703062 | ||
| Steric control of oxygenation regiochemistry in soybean lipoxygenase-1. | Q49314277 | ||
| Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase. | Q52627547 | ||
| Stabilization of purified human 5-lipoxygenase with glutathione peroxidase and superoxide dismutase | Q72851730 | ||
| Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis | Q24299373 | ||
| Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein | Q24315769 | ||
| The 1.85 Å Structure of an 8 R -Lipoxygenase Suggests a General Model for Lipoxygenase Product Specificity | Q27646536 | ||
| Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase | Q27646754 | ||
| Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis | Q27646755 | ||
| Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data | Q27648040 | ||
| Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution | Q27733249 | ||
| The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity | Q27748747 | ||
| CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues | Q27860729 | ||
| Calcium binding to 5-lipoxygenase | Q28187251 | ||
| The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation | Q30168672 | ||
| Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein/5-lipoxygenase fusion proteins | Q30175979 | ||
| Solution structure of p53 core domain: structural basis for its instability | Q31031898 | ||
| Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid | Q34708491 | ||
| Improving protein crystal quality by selective removal of a Ca(2+)-dependent membrane-insertion loop | Q36588458 | ||
| Control of oxygenation in lipoxygenase and cyclooxygenase catalysis | Q36831450 | ||
| Biosynthesis and metabolism of leukotrienes | Q36876280 | ||
| What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases | Q37054603 | ||
| 5-Lipoxygenase: mechanisms of regulation | Q37173201 | ||
| A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation | Q37595527 | ||
| Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase | Q40756579 | ||
| P433 | issue | 6014 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Arachidonate 5-lipoxygenase | Q411791 |
| leukotriene biosynthetic process | Q14889542 | ||
| P304 | page(s) | 217-9 | |
| P577 | publication date | 2011-01-14 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | The structure of human 5-lipoxygenase | |
| P478 | volume | 331 |
| Q38100199 | 5-Lipoxygenase inhibitors: a review of recent patents (2010-2012). |
| Q36812054 | 5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation |
| Q57033924 | A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein |
| Q96816595 | A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors |
| Q42098828 | ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid |
| Q24298266 | Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS |
| Q54982673 | Anti-inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions. |
| Q36139722 | Anti-inflammatory trends of new benzimidazole derivatives. |
| Q89411784 | Application of Docking Analysis in the Prediction and Biological Evaluation of the Lipoxygenase Inhibitory Action of Thiazolyl Derivatives of Mycophenolic Acid |
| Q43747796 | Aspirin analogues as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, nitric oxide release, molecular modeling, and biological evaluation as anti-inflammatory agents. |
| Q34162962 | Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes |
| Q42325385 | Catalytic convergence of manganese and iron lipoxygenases by replacement of a single amino acid |
| Q35150284 | Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity |
| Q64950753 | Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members. |
| Q56971357 | Chemical composition and anti-inflammatory activity of the essential oils of Psidium guajava fruits and leaves |
| Q37191669 | Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol |
| Q51595757 | Computational insight into the catalytic implication of head/tail-first orientation of arachidonic acid in human 5-lipoxygenase: consequences for the positional specificity of oxygenation. |
| Q50541287 | Computer modeling in predicting the bioactivity of human 5-lipoxygenase inhibitors. |
| Q27678617 | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663 |
| Q39971521 | Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzae |
| Q27681754 | Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis |
| Q30366916 | Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. |
| Q38618953 | Crystallization and preliminary crystallographic analysis of manganese lipoxygenase |
| Q28487727 | Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton |
| Q39176781 | Design, Synthesis, and Biological Evaluation of Some Novel Pyrrolizine Derivatives as COX Inhibitors with Anti-Inflammatory/Analgesic Activities and Low Ulcerogenic Liability. |
| Q38914579 | Development of novel aminothiazole-comprising 5-LO inhibitors |
| Q53821950 | Dietary resveratrol impairs body weight gain due to reduction of feed intake without affecting fatty acid composition in Atlantic salmon. |
| Q34066023 | Dimerization of human 5-lipoxygenase |
| Q33595066 | Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection. |
| Q28534270 | Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy |
| Q43817627 | Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase |
| Q93108587 | Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia |
| Q33632763 | Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation |
| Q38925866 | Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase. |
| Q46209101 | Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase |
| Q35528988 | Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism |
| Q38272869 | Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling. |
| Q35559135 | Exploration of binding site pattern in arachidonic acid metabolizing enzymes, Cyclooxygenases and Lipoxygenases |
| Q36727908 | Exploring N(1)-p-fluorobenzyl-cymserine as an inhibitor of 5-lipoxygenase as a candidate for type 2 diabetes and neurodegenerative disorder treatment |
| Q64892416 | Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla. |
| Q52316727 | Extracellular Vesicles as Conveyors of Membrane-Derived Bioactive Lipids in Immune System. |
| Q51434937 | From Molecular Docking to 3D-Quantitative Structure-Activity Relationships (3D-QSAR): Insights into the Binding Mode of 5-Lipoxygenase Inhibitors. |
| Q90603077 | Functional characterization of a novel arachidonic acid 12S-lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns |
| Q37341356 | Functional characterization of genetic enzyme variations in human lipoxygenases |
| Q92403172 | Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis |
| Q37281453 | Helical membrane protein conformations and their environment |
| Q36195133 | Identification and Characterization of a New Protein Isoform of Human 5-Lipoxygenase |
| Q38956807 | Identification and molecular characterization of a novel splice variant of human 5- lipoxygenase gene. |
| Q103002271 | Identification of a novel enzyme from E. pacifica that acts as an eicosapentaenoic 8R-LOX and docosahexaenoic 10R-LOX |
| Q36648981 | Identification of the Substrate Access Portal of 5-Lipoxygenase |
| Q42220568 | Impact of embedded endocannabinoids and their oxygenation by lipoxygenase on membrane properties |
| Q39153607 | Impact of wines and wine constituents on cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase catalytic activity. |
| Q38340154 | Industrial potential of lipoxygenases. |
| Q38772584 | Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production |
| Q38066761 | Iron speciation in the cytosol: an overview |
| Q91971650 | Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation |
| Q33855839 | Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer |
| Q42559839 | Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2. |
| Q48706704 | Leukotriene inflammatory mediators meet their match |
| Q37953364 | Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation |
| Q41962866 | Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus. |
| Q38382387 | Lipoxygenase directed anti-inflammatory and anti-cancerous secondary metabolites: ADMET-based screening, molecular docking and dynamics simulation. |
| Q28709175 | Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms |
| Q36439481 | Locating a lipid at the portal to the lipoxygenase active site |
| Q28249730 | Mammalian lipoxygenases and their biological relevance |
| Q51100714 | Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy. |
| Q38632716 | Molecular Dynamics Study on the Apo- and Holo-forms of 5-Lipoxygenase |
| Q41978118 | Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease. |
| Q52322716 | Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives. |
| Q41774015 | Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor |
| Q59145770 | New Caffeic Acid Phenylethyl Ester Analogs Bearing Substituted Triazole: Synthesis and Structure-Activity Relationship Study towards 5-Lipoxygenase Inhibition |
| Q41079727 | New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis. |
| Q37492447 | Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells |
| Q39049264 | Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents |
| Q90116332 | Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells |
| Q39555808 | Potent inhibitors of 5-lipoxygenase identified using pseudoreceptors |
| Q38187948 | Psychopharmacological treatment of neurocognitive deficits in people with schizophrenia: a review of old and new targets |
| Q33960685 | Rationally designed multitarget agents against inflammation and pain |
| Q28296738 | Recent advances in the search for novel 5-lipoxygenase inhibitors |
| Q24564308 | Regulation of inflammation in cancer by eicosanoids |
| Q48163960 | Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads from Enzyme-Mediated Fragmentation of Natural Products |
| Q34025563 | Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis |
| Q38757063 | Serum 5-LOX: a progressive protein marker for breast cancer and new approach for therapeutic target. |
| Q38796078 | Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept |
| Q47951198 | Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange |
| Q35968860 | Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs |
| Q94563350 | Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products |
| Q27679822 | Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa |
| Q36345885 | Structure and ligand based drug design strategies in the development of novel 5- LOX inhibitors |
| Q27678989 | Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ Regulation |
| Q39150746 | Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO. |
| Q48207987 | Substituted Caffeic and Ferulic Acid Phenethyl Esters: Synthesis, Leukotrienes Biosynthesis Inhibition, and Cytotoxic Activity. |
| Q60860104 | Substrate binding to mammalian 15-lipoxygenase |
| Q59830619 | Targeting Metalloenzymes for Therapeutic Intervention |
| Q43464822 | Targeting leukotriene B4 in inflammation |
| Q38170191 | The genetics of vascular incidents associated with second-generation antipsychotic administration |
| Q38938662 | The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. |
| Q26795652 | The role of lipoxygenases in pathophysiology; new insights and future perspectives |
| Q90325967 | The role of propofol hydroxyl group in 5-lipoxygenase recognition |
| Q30153264 | The structural basis for specificity in lipoxygenase catalysis |
| Q24329199 | The structure of human 15-lipoxygenase-2 with a substrate mimic |
| Q90169853 | Two and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils |
| Q38167040 | Two faces of inflammation: an immunopharmacological view |
| Q42773873 | Virtual Dual inhibition of COX-2 / 5-LOX enzymes based on binding properties of alpha-amyrins, the anti-inflammatory compound as a promising anti-cancer drug. |
| Q41595533 | Water-soluble Fe(II)-H2O complex with a weak O-H bond transfers a hydrogen atom via an observable monomeric Fe(III)-OH. |
Search more.