Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663

scientific article

Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1096/FJ.12-205286
P932PMC publication ID3405276
P698PubMed publication ID22516296
P5875ResearchGate publication ID224768765

P2093author name stringMarcia E Newcomer
David B Neau
Sue G Bartlett
William E Boeglin
Nathaniel C Gilbert
Zhe Rui
Alan R Brash
Maria T Waight
P2860cites workRequirement of a 5-lipoxygenase-activating protein for leukotriene synthesisQ24299373
The structure of human 5-lipoxygenaseQ24337021
The 1.85 Å Structure of an 8 R -Lipoxygenase Suggests a General Model for Lipoxygenase Product SpecificityQ27646536
Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic dataQ27648040
The three-dimensional structure of an arachidonic acid 15-lipoxygenaseQ27732168
Crystal structure of a trapped phosphoenzyme during a catalytic reactionQ27741389
Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzymeQ27743059
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificityQ27748747
Coot: model-building tools for molecular graphicsQ27860505
Protein production by auto-induction in high density shaking culturesQ27860514
Automated structure solution with the PHENIX suiteQ27860642
Phasercrystallographic softwareQ27860930
Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cellsQ28196391
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinasesQ28344173
Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytesQ28622785
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediatorsQ29615694
Crystal structures of vegetative soybean lipoxygenase VLX-B and VLX-D, and comparisons with seed isoforms LOX-1 and LOX-3Q30159617
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acidQ34708491
Mammalian lipoxygenases: molecular structures and functionsQ35460975
Constitutive activation of Mek1 by mutation of serine phosphorylation sitesQ35756491
A comprehensive model of positional and stereo control in lipoxygenasesQ36235760
Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophilsQ36353858
Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responsesQ36591942
ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthmaQ37003847
Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.Q37029845
What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseasesQ37054603
5-Lipoxygenase: mechanisms of regulationQ37173201
Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesisQ37759804
Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytesQ40707404
Intra- and extracellular expression of rabbit reticulocyte 15-lipoxygenase in the Baculovirus/insect cell systemQ40999643
Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase.Q42809059
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).Q43886305
5-Lipoxygenase activation by MAPKAPK-2 and ERKs.Q44443993
Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chiralityQ46703062
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophilsQ46794842
Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase.Q52627547
Lipoxin formation in human plateletsQ67913646
Conversion of serine to aspartate imitates phosphorylation-induced changes in the structure and function of microtubule-associated protein tauQ73174615
Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomallaQ73176170
Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in miceQ85224255
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
Arachidonate 5-lipoxygenaseQ411791
arachidonate 5-lipoxygenase activityQ14889547
P304page(s)3222-9
P577publication date2012-08-01
P1433published inFASEB JournalQ520194
P1476titleConversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663
P478volume26

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cites work (P2860)
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