Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase

scientific article

Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JSB.2004.01.011
P698PubMed publication ID15099582
P5875ResearchGate publication ID8604350

P50authorMavis Agbandje-McKennaQ28036887
Lakshmanan GovindasamyQ28919048
Robert McKennaQ28036881
P2093author name stringShouguang Jin
Donghai Wu
Wei Lian
Thomas Kukar
Brenda Pedersen
Yunrong Gu
P2860cites workCation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and TrpQ28271872
CarnitineQ28289103
The carnitine acyltransferases: modulators of acyl-CoA-dependent reactionsQ33921318
Molecular enzymology of carnitine transfer and transportQ33938860
Molecular cloning of cDNAs encoding human carnitine acetyltransferase and mapping of the corresponding gene to chromosome 9q34.1.Q36713208
cDNA cloning, recombinant expression, and site-directed mutagenesis of bovine liver carnitine octanoyltransferase--Arg505 binds the carboxylate group of carnitineQ36881548
Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guideQ37284698
Carnitine deficiency syndromesQ37923366
The carnitine acyltransferases and their role in modulating acyl-CoA poolsQ40904882
Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferaseQ48571598
Purification and assay of carnitine acyltransferasesQ69497362
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
cDNA cloning, sequence analysis, and chromosomal localization of human carnitine palmitoyltransferaseQ24559967
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesteraseQ24561371
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
Crystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
PROCHECK: a program to check the stereochemical quality of protein structuresQ26778411
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transportQ27640305
Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transferQ27640412
Raster3D: photorealistic molecular graphicsQ27860557
An extensively modified version of MolScript that includes greatly enhanced coloring capabilitiesQ27860594
LIGPLOT: a program to generate schematic diagrams of protein-ligand interactionsQ27861128
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcarnitine metabolic process, CoA-linkedQ21113688
carnitine O-acetyltransferaseQ21142228
P304page(s)416-24
P577publication date2004-06-01
P1433published inJournal of Structural BiologyQ3186947
P1476titleStructural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase
P478volume146

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cites work (P2860)
Q28513264Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity
Q28578888Crystal structure of rat carnitine palmitoyltransferase II (CPT-II)
Q24607519Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates
Q28265071Identification of 16 new disease-causing mutations in the CPT2 gene resulting in carnitine palmitoyltransferase II deficiency
Q43242725Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism
Q28568653Redesign of carnitine acetyltransferase specificity by protein engineering
Q37476799Structural insight into function and regulation of carnitine palmitoyltransferase
Q38927327Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

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