Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer (scientific article (publication date: 11 April 2003))

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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cDNA cloning, sequence analysis, and chromosomal localization of the gene for human carnitine palmitoyltransferase

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Q26776980

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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PROCHECK: a program to check the stereochemical quality of protein structures

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Processing of X-ray diffraction data collected in oscillation mode

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ALSCRIPT: a tool to format multiple sequence alignments

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An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

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Protein structure comparison by alignment of distance matrices

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex

Q28289032

Carnitine

Q28289103

Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain

Q28564300

The PROSITE database, its status in 2002

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The carnitine acyltransferases: modulators of acyl-CoA-dependent reactions

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Molecular enzymology of carnitine transfer and transport

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The conserved serine-threonine-serine motif of the carnitine acyltransferases is involved in carnitine binding and transition-state stabilization: a site-directed mutagenesis study

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Molecular cloning of cDNAs encoding human carnitine acetyltransferase and mapping of the corresponding gene to chromosome 9q34.1.

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cDNA cloning, recombinant expression, and site-directed mutagenesis of bovine liver carnitine octanoyltransferase--Arg505 binds the carboxylate group of carnitine

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The carnitine acyltransferases and their role in modulating acyl-CoA pools

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Specific alkylation of a histidine residue in carnitine acetyltransferase by bromoacetyl-l-carnitine

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Some kinetic studies on the mechanism of action of carnitine acetyltransferase

Q42133408

Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity

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Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase

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Expression, purification, and characterization of recombinant Drosophila choline acetyltransferase.

Q52545234

P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

13159-65

P577

publication date

2003-04-11

P1433

published in

Journal of Biological Chemistry

Q867727

P1476

title

Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer

P478

volume

278

Reverse relations

cites work (P2860)

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Q37190404	Carnitine palmitoyltransferase IA polymorphism P479L is common in Greenland Inuit and is associated with elevated plasma apolipoprotein A-I
Q34571971	Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders.
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Q85679997	Computational study enlightens the structural role of the alcohol acyltransferase DFGWG motif
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Q28578888	Crystal structure of rat carnitine palmitoyltransferase II (CPT-II)
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Q28265071	Identification of 16 new disease-causing mutations in the CPT2 gene resulting in carnitine palmitoyltransferase II deficiency
Q43242725	Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism
Q58795535	Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement
Q50466880	Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane.
Q28568653	Redesign of carnitine acetyltransferase specificity by protein engineering
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Q45807395	Structural analysis of the alcohol acyltransferase protein family from Cucumis melo shows that enzyme activity depends on an essential solvent channel.
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Q33993041	Structural and functional studies suggest a catalytic mechanism for the phosphotransacetylase from Methanosarcina thermophila
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Q50293694	acetyl-CoA + carnitine => acetylcarnitine + CoASH
Q47268040	l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug
Q50293697	propionyl-CoA + carnitine => propionylcarnitine + CoASH

P356	DOI	10.1074/JBC.M212356200
P698	PubMed publication ID	12562770