Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity

scientific article

Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M106920200
P698PubMed publication ID11553629

P50authorDolors Serra CucurullQ41464641
Paulino Gómez-PuertasQ43022661
P2093author name stringValencia A
Hegardt FG
Roca R
Morillas M
Asins G
P2860cites workProMod and Swiss-Model: Internet-based tools for automated comparative protein modellingQ29617090
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The conserved serine-threonine-serine motif of the carnitine acyltransferases is involved in carnitine binding and transition-state stabilization: a site-directed mutagenesis studyQ34441620
High expression of a novel carnitine palmitoyltransferase I like protein in rat brown adipose tissue and heart: isolation and characterization of its cDNA cloneQ36701696
cDNA cloning, recombinant expression, and site-directed mutagenesis of bovine liver carnitine octanoyltransferase--Arg505 binds the carboxylate group of carnitineQ36881548
Molecular basis of hepatic carnitine palmitoyltransferase I deficiencyQ37384234
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Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferaseQ42799776
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Protein modelling for allQ57075376
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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the geneQ24317500
Basic local alignment search toolQ25938991
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The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA moleculeQ27748869
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WHAT IF: a molecular modeling and drug design programQ27860734
Errors in protein structuresQ27860776
CATH--a hierarchic classification of protein domain structuresQ27861100
High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrierQ28131646
Genomics of the human carnitine acyltransferase genesQ28139379
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Database of homology-derived protein structures and the structural meaning of sequence alignmentQ29614393
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectL-alanineQ218642
P304page(s)45001-45008
P577publication date2001-09-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleStructural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity
P478volume276

Reverse relations

cites work (P2860)
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Q50098089Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
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Q28296650Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis
Q28298983Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A
Q28483041Drosophila melanogaster Acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system
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