Epidermal wound repair is regulated by the planar cell polarity signaling pathway

scientific article published on 20 July 2010

Epidermal wound repair is regulated by the planar cell polarity signaling pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.DEVCEL.2010.06.008
P8608Fatcat IDrelease_yh67rduba5eidcwztrjwk25tsm
P3181OpenCitations bibliographic resource ID2938275
P932PMC publication ID2965174
P698PubMed publication ID20643356
P5875ResearchGate publication ID45274525

P50authorAnthony T. PapenfussQ30348326
Sebastian DworkinQ42799609
Patrick O. HumbertQ54591963
Quan ZhaoQ55300520
Charbel DaridoQ58876642
Tomasz WilanowskiQ59697359
P2093author name stringAlana Auden
Gerhard Rank
Jacinta Caddy
Jennifer N Murdoch
Jian Zuo
John M Cunningham
Nidal Boulos
Seema Srivastava
Stephen B Ting
Stephen M Jane
Thomas Weber
Vishwas Parekh
P2860cites workA highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyheadQ24304288
WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulationQ24311637
Perturbed desmosomal cadherin expression in grainy head-like 1-null miceQ24315989
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomesQ24534193
Healing of incisional wounds in the embryonic chick wing bud: characterization of the actin purse-string and demonstration of a requirement for Rho activationQ24681878
A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical developmentQ24798758
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouseQ28184694
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1Q28214701
Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouseQ28218970
The role of RhoA in tissue polarity and Frizzled signallingQ28238365
The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edgeQ28268615
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closureQ28507430
Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3Q28507977
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathwayQ28509023
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair folliclesQ28513824
Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migrationQ28574344
A homolog of Drosophila grainy head is essential for epidermal integrity in miceQ28585220
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebratesQ28587777
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complexQ28590249
The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migrationQ28591521
Identification of Vangl2 and Scrb1 as planar polarity genes in mammalsQ28593071
Wound healing--aiming for perfect skin regenerationQ29616715
Dishevelled controls cell polarity during Xenopus gastrulationQ29619295
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeletonQ29620156
WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.Q30160832
Planar signaling and morphogenesis in DrosophilaQ30309355
Shaping the vertebrate body plan by polarized embryonic cell movementsQ30310311
Rho1 has multiple functions in Drosophila wing planar polarityQ30434910
Rho GTPases and the control of cell behaviourQ34462373
Role of Rho family GTPases in epithelial morphogenesisQ34631560
A quest for the mechanism regulating global planar cell polarity of tissuesQ34989405
Roles of Rho-family GTPases in cell polarisation and directional migrationQ35547373
Parallels between tissue repair and embryo morphogenesisQ35805187
Wound healing and inflammation: embryos reveal the way to perfect repairQ35855738
Coordinating cytoskeletal tracks to polarize cellular movementsQ35927687
Planar cell polarization: an emerging model points in the right directionQ36280306
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundlesQ36321444
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motilityQ36710748
Planar polarity and tissue morphogenesisQ36851258
Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closureQ41278303
The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.Q42117934
Analysis of the tissue movements of embryonic wound healing--DiI studies in the limb bud stage mouse embryoQ42480105
Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1).Q42494870
Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1.Q42510219
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tailQ42653433
An epidermal barrier wound repair pathway in Drosophila is mediated by grainy headQ42653591
Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movementsQ42791086
The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wingQ44899746
Twinstar, the Drosophila homolog of cofilin/ADF, is required for planar cell polarity patterning.Q45977669
Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epitheliumQ46892759
Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton.Q47070036
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.Q50483907
Grhl3 and Lmo4 play coordinate roles in epidermal migration.Q51952633
Coupling planar cell polarity signaling to morphogenesis.Q52104120
Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye.Q52165280
Role of PKA as a negative regulator of PCP signaling pathway during Xenopus gastrulation movements.Q53603400
Cofilin takes the lead.Q53628956
Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutationQ77165546
Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epitheliumQ78319031
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectregulation of actin cytoskeleton organizationQ14876082
Rho guanine nucleotide exchange factor 19Q21101977
Grainyhead like transcription factor 3Q21111403
Cadherin, EGF LAG seven-pass G-type receptor 1Q21494076
Grainyhead like transcription factor 3Q21495780
Rho guanine nucleotide exchange factor (GEF) 19Q21496934
Scribbled planar cell polarityQ21498176
PTK7 protein tyrosine kinase 7Q21980117
VANGL planar cell polarity 2Q21981325
P304page(s)138-47
P577publication date2010-07-20
P1433published inDevelopmental CellQ1524277
P1476titleEpidermal wound repair is regulated by the planar cell polarity signaling pathway
P478volume19

Reverse relations

cites work (P2860)
Q28587867A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia
Q36802288A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3.
Q38048237A consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects
Q30846970A current affair: electrotherapy in wound healing
Q37530244A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13.
Q39004702Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration.
Q36816326Adult zebrafish as a model system for cutaneous wound-healing research
Q36387183Alcohol Consumption Modulates Host Defense in Rhesus Macaques by Altering Gene Expression in Circulating Leukocytes
Q39384017Alternative splicing and start sites: Lessons from the Grainyhead-like family.
Q92006428Beta-caryophyllene enhances wound healing through multiple routes
Q26801778Cellular and molecular mechanisms of repair in acute and chronic wound healing
Q57039861Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis
Q35759101Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis
Q52611754Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase.
Q38276290Epidermal polarity genes in health and disease
Q36915469Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected].
Q35697490Expanding the morphogenetic repertoire: perspectives from the Drosophila egg
Q91639633Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury
Q42129608GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states.
Q47816048Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl.
Q40395576Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate
Q42868440Golgi Feels Its Own Wound
Q48410341Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice
Q89487153Grainyhead-like transcription factors in cancer - Focus on recent developments
Q35049664Grhl3 and GEF19 in the front rho.
Q48373324Grhl3 modulates epithelial structure formation of the circumvallate papilla during mouse development.
Q33588100Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair
Q41378375Histomorphological observation of surgical debridement combined with negative pressure therapy in treatment of diabetic foot
Q24631607How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals
Q28834533Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma
Q33822383Interferon regulatory factor 6 regulates keratinocyte migration
Q41649077Kinase-interacting substrate screening is a novel method to identify kinase substrates
Q46253395Learning from regeneration research organisms: The circuitous road to scar free wound healing.
Q38707291Long-Lived Epidermal Cancer-Initiating Cells
Q57809715Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis
Q91338211Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs
Q36166517Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic development.
Q47131806Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.
Q24322638Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans
Q59138238Neglected Functions of TFCP2/TFCP2L1/UBP1 Transcription Factors May Offer Valuable Insights into Their Mechanisms of Action
Q39135434Neural tube closure: cellular, molecular and biomechanical mechanisms
Q64933040Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.
Q42243217PTK7 Faces the Wnt in Development and Disease
Q37255487PTK7 overexpression in colorectal tumors: Clinicopathological correlation and prognosis relevance
Q35788789PTK7 regulates Id1 expression in CD44-high glioma cells
Q26823939Palatogenesis and cutaneous repair: A two-headed coin
Q40375592Patterning skin by planar cell polarity: the multi-talented hair designer
Q34490793Phosphorylation of Grainy head by ERK is essential for wound-dependent regeneration but not for development of an epidermal barrier
Q28508422Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia
Q35624641Planar cell polarity in Drosophila
Q38111369Planar cell polarity signaling in collective cell movements during morphogenesis and disease
Q42766121Planar polarity pathway and Nance-Horan syndrome-like 1b have essential cell-autonomous functions in neuronal migration.
Q35624649Planar polarity: A new player in both lung development and disease
Q37866626Pointing in the right direction: new developments in the field of planar cell polarity.
Q91646552Potassium channels as potential drug targets for limb wound repair and regeneration
Q38489607Proteomic approach to skin regeneration in a marine teleost: modulation by oestradiol-17β.
Q26738712Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer
Q38918994Rare deleterious variants in GRHL3 are associated with human spina bifida
Q37036205Re-epithelialization of cutaneous wounds in adult zebrafish combines mechanisms of wound closure in embryonic and adult mammals
Q37071218Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer
Q38154247Regulation of PCP by the Fat signaling pathway
Q30275422Regulation of Transcription Factors by Reactive Oxygen Species and Nitric Oxide in Vascular Physiology and Pathology
Q26795741Regulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins
Q39438840Roles of Grainyhead-like transcription factors in cancer
Q99712241Spotlight on the Granules (Grainyhead-Like Proteins) - From an Evolutionary Conserved Controller of Epithelial Trait to Pioneering the Chromatin Landscape
Q38118084Stem cells behind the barrier.
Q33978393Structural and temporal requirements of Wnt/PCP protein Vangl2 function for convergence and extension movements and facial branchiomotor neuron migration in zebrafish
Q28512411Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity
Q42016672The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium
Q38038640The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.
Q60950784The Scribble–Dlg–Lgl Module in Cell Polarity Regulation
Q42513953The core planar cell polarity gene, Vangl2, maintains apical-basal organisation of the corneal epithelium
Q33799070The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.
Q21710722The many roles of PTK7: A versatile regulator of cell–cell communication
Q37951269The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair
Q38697013The preventive effects of taurine on neural tube defects through the Wnt/PCP-Jnk-dependent pathway
Q50494321The role of Rho kinase (Rock) in re-epithelialization of adult zebrafish skin wounds.
Q38797349The role of barrier genes in epidermal malignancy
Q38084899The role of transcription-independent damage signals in the initiation of epithelial wound healing
Q50636049The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling.
Q24307451The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity
Q37845405Tissue repair and regeneration in Drosophila imaginal discs.
Q24293242Two isoforms of Sister-Of-Mammalian Grainyhead have opposing functions in endothelial cells and in vivo
Q34663887Understanding cadherin EGF LAG seven-pass G-type receptors.
Q47619354Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development.
Q92884310Wnt/PCP Signaling Contribution to Carcinoma Collective Cell Migration and Metastasis
Q39441374Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment
Q38056451Wound healing in development
Q37152090Wound repair and regeneration: mechanisms, signaling, and translation
Q36929762Wound repair: toward understanding and integration of single-cell and multicellular wound responses
Q64951157p73 regulates epidermal wound healing and induced keratinocyte programming.

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