Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription

scientific article

Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID109751
P698PubMed publication ID9525626

P2093author name stringL A Stark
R T Hay
P2860cites workThe Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cellsQ24564509
Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetasesQ24630983
Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzymeQ24684302
Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 VprQ24684633
Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activityQ24685633
The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycleQ24685965
Solution structure of the anticodon-binding domain of Escherichia coli lysyl-tRNA synthetase and studies of its interaction with tRNA(Lys)Q27729274
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunitQ27860669
Mammalian Ras interacts directly with the serine/threonine kinase RafQ27860833
Improved method for high efficiency transformation of intact yeast cellsQ28131608
A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coliQ28131613
The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIBQ28289504
The polyanion-binding domain of cytoplasmic Lys-tRNA synthetase from Saccharomyces cerevisiae is not essential for cell viabilityQ38327700
Amino acid biosynthesis inhibitors as herbicidesQ39532159
The occurrence of duplicate lysyl-tRNA synthetase gene homologs in Escherichia coli and other procaryotesQ39836246
Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control.Q39874039
Effect of human immunodeficiency virus type 1 protein R (vpr) gene expression on basic cellular function of fission yeast Schizosaccharomyces pombe.Q39875974
Activation of adenovirus-coded protease and processing of preterminal protein.Q40042441
Priming of HIV replication by tRNA(Lys3): role of reverse transcriptaseQ40389611
HIV accessory proteins: leading roles for the supporting cast.Q40456339
Aminoacyl-tRNA synthetasesQ40540909
The activation domain of a basic helix-loop-helix protein is masked by repressor interaction with domains distinct from that required for transcription regulationQ40791796
HIV-1, Vpr and the cell cycleQ41110933
Recent advances. HIV infection--I.Q41369847
HIV accessory proteins as therapeutic targetsQ41421578
Induction of cell differentiation by human immunodeficiency virus 1 vpr.Q41572634
HIV enhancer activity perpetuated by NF-kappa B induction on infection of monocytesQ41687061
The Vpr protein of human immunodeficiency virus type 1 binds to nucleocapsid protein p7 in vitroQ44401398
Protection of monkeys vaccinated with vpr- and/or nef-defective simian immunodeficiency virus strain mac/human immunodeficiency virus type 1 chimeric viruses: a potential candidate live-attenuated human AIDS vaccineQ45763014
Characterization of a leucine-zipper-like domain in Vpr protein of human immunodeficiency virus type 1.Q45766300
Mutational isolation of a sieve for editing in a transfer RNA synthetase.Q54635732
Aminoacylation error correctionQ60089451
Coexistence of two antisynthetases in a patient with the antisynthetase syndromeQ71077880
Initiation of reverse transcription of HIV-1: secondary structure of the HIV-1 RNA/tRNA(3Lys) (template/primer)Q72134543
Interaction of Virion Protein Vpr of Human Immunodeficiency Virus Type 1 with Cellular Transcription Factor Sp1 and trans-Activation of Viral Long Terminal RepeatQ28291807
Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vprQ28302512
The glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene productQ28368083
Physical and biochemical characterization of a purified arginyl-tRNA synthetase-lysyl-tRNA-synthetase complex from rat liverQ28578286
Role of Pr160gag-pol in mediating the selective incorporation of tRNA(Lys) into human immunodeficiency virus type 1 particlesQ28646824
Identification of tRNAs incorporated into wild-type and mutant human immunodeficiency virus type 1Q28646853
Regulation of the yeast HO geneQ29618279
Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytesQ29619514
The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophagesQ33849520
Evolution of the primate lentiviruses: evidence from vpx and vprQ33938392
Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.Q34341976
A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects.Q34501320
The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.Q35831790
Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency.Q35832979
vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeysQ35844498
Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vprQ35846506
A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particlesQ35850368
Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation.Q35850945
A conserved LXXLF sequence is the major determinant in p6gag required for the incorporation of human immunodeficiency virus type 1 Vpr.Q35853370
Specific initiation and switch to elongation of human immunodeficiency virus type 1 reverse transcription require the post-transcriptional modifications of primer tRNA3LysQ35853488
Vpr-induced cell cycle arrest is conserved among primate lentiviruses.Q35859146
Effects of modifying the tRNA(3Lys) anticodon on the initiation of human immunodeficiency virus type 1 reverse transcriptionQ35864780
Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1Q35882940
Recent advances. HIV infection-IIQ36243123
Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particlesQ36630330
Molecular biology of the human immunodeficiency virus accessory proteinsQ36636712
Incorporation of excess wild-type and mutant tRNA(3Lys) into human immunodeficiency virus type 1.Q36637578
Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophagesQ36650619
Human immunodeficiency virus type 1 viral protein R localization in infected cells and virionsQ36654319
Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis.Q36655127
Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinantsQ36698525
Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus.Q36770468
The anticodon triplet is not sufficient to confer methionine acceptance to a transfer RNAQ37296570
Functions of the auxiliary gene products of the human immunodeficiency virus type 1.Q37948729
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectvirologyQ7215
P1104number of pages8
P304page(s)3037-3044
P577publication date1998-04-01
P1433published inJournal of VirologyQ1251128
P1476titleHuman immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription
P478volume72

Reverse relations

cites work (P2860)
Q36973475Aminoacyl-tRNA synthetase complexes: molecular multitasking revealed
Q53220900Association of human mitochondrial lysyl-tRNA synthetase with HIV-1 GagPol does not require other viral proteins.
Q38209320DNA damage repair machinery and HIV escape from innate immune sensing.
Q92732582Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins
Q33787316Functional role of residues corresponding to helical domain II (amino acids 35 to 46) of human immunodeficiency virus type 1 Vpr.
Q26746070HIV Genome-Wide Protein Associations: a Review of 30 Years of Research
Q37689513HIV-1 Vpr-a still "enigmatic multitasker".
Q24529517Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1
Q24514760Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription
Q57971522Modulating the activity of the channel-forming segment of Vpr protein from HIV-1
Q21245198Protein methylation is required to maintain optimal HIV-1 infectivity
Q35018131The (52-96) C-terminal domain of Vpr stimulates HIV-1 IN-mediated homologous strand transfer of mini-viral DNA
Q21245211The Vpr protein from HIV-1: distinct roles along the viral life cycle
Q53582168The dose-dependent H2O2 stress response promotes increased survival for Schizosaccharomyces pombe cells expressing HIV-1 Vpr.
Q39591236Transdominant activity of human immunodeficiency virus type 1 Vpr with a mutation at residue R73.
Q35634277Viral hijacking of mitochondrial lysyl-tRNA synthetase
Q38164707Viruses as modulators of mitochondrial functions
Q33828332Vpr-host interactions during HIV-1 viral life cycle

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