Rab27a is an essential component of melanosome receptor for myosin Va

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Rab27a is an essential component of melanosome receptor for myosin Va is …
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scholarly articleQ13442814

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P356DOI10.1091/MBC.01-12-0595
P3181OpenCitations bibliographic resource ID4042992
P932PMC publication ID111140
P698PubMed publication ID12006666
P5875ResearchGate publication ID11363945

P2093author name stringFei Wang
John A Hammer
Xufeng Wu
James R Sellers
Kang Rao
P2860cites workRab27a: A key to melanosome transport in human melanocytesQ24290970
Interaction of a Golgi-associated kinesin-like protein with Rab6Q24322499
Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden miceQ24555217
The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesisQ24598235
Myosin vb is associated with plasma membrane recycling systemsQ24633656
Rab proteins as membrane organizersQ27860861
The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targetingQ27932330
Polarization of cell growth in yeastQ27934842
Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesiclesQ27939177
Identification and characterization of a family of Rab11-interacting proteinsQ28211889
Effect of ADP and ionic strength on the kinetic and motile properties of recombinant mouse myosin VQ28369753
Cultured melanocytes from dilute mutant mice exhibit dendritic morphology and altered melanosome distributionQ28505197
Molecular genetic dissection of mouse unconventional myosin-VA: tail region mutationsQ28507012
Rab27a regulates the peripheral distribution of melanosomes in melanocytesQ28513638
Novel myosin heavy chain encoded by murine dilute coat colour locusQ28590446
Retroviral sequences located within an intron of the dilute gene alter dilute expression in a tissue-specific mannerQ28592127
Myosin V associates with melanosomes in mouse melanocytes: evidence that myosin V is an organelle motorQ28593276
A mutation in Rab27a causes the vesicle transport defects observed in ashen miceQ28594384
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndromeQ29620423
The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domainsQ30168083
Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chainsQ30308374
Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.Q32066956
Class V myosins.Q33866590
The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and lnQ33954448
Deficient geranylgeranylation of Ram/Rab27 in choroideremia.Q34298202
Rabs grab motors: defining the connections between Rab GTPases and motor proteinsQ34495175
Localization of myosin-V in the centrosomeQ36208787
Regulation of melanosome movement in the cell cycle by reversible association with myosin V.Q36301417
Two distinct regions in a yeast myosin-V tail domain are required for the movement of different cargoesQ36328460
Visualization of melanosome dynamics within wild-type and dilute melanocytes suggests a paradigm for myosin V function In vivoQ36328552
Molecular analysis of two mouse dilute locus deletion mutations: spontaneous dilute lethal20J and radiation-induced dilute prenatal lethal Aa2 allelesQ36716529
Subcellular localization of myosin-V in the B16 melanoma cells, a wild-type cell line for the dilute geneQ36931767
Cloning and characterization of myr 6, an unconventional myosin of the dilute/myosin-V familyQ37297817
The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis.Q39458921
Rab5 regulates motility of early endosomes on microtubulesQ40916867
Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II.Q43710205
Myosin V colocalizes with melanosomes and subcortical actin bundles not associated with stress fibers in human epidermal melanocytesQ49171689
The light chain composition of chicken brain myosin-Va: calmodulin, myosin-II essential light chains, and 8-kDa dynein light chain/PIN.Q52144362
Brain myosin-V is a two-headed unconventional myosin with motor activityQ70488210
Utrastructural observations on melanosome aggregation in genetically defective melanocytes of the mouseQ71104248
Effects of acid phospholipids on nucleotide exchange properties of ADP-ribosylation factor 1. Evidence for specific interaction with phosphatidylinositol 4,5-bisphosphateQ72808716
Purification and identification of novel Rab effectors using affinity chromatographyQ73556453
The predominant defect in dilute melanocytes is in melanosome distribution and not cell shape, supporting a role for myosin V in melanosome transportQ73830033
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)1735-1749
P577publication date2002-05-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleRab27a is an essential component of melanosome receptor for myosin Va
P478volume13

Reverse relations

cites work (P2860)
Q39084617A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes.
Q41978648A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule level
Q90746323A novel function of Prohibitin on melanosome transport in melanocytes
Q33327321A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome
Q47234353A role for myosin Va in human cytomegalovirus nuclear egress
Q44843967Actin-dependent motility of melanosomes from fish retinal pigment epithelial (RPE) cells investigated using in vitro motility assays
Q38925051Actin-myosin network is required for proper assembly of influenza virus particles.
Q40401709Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.
Q37348756Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.
Q28209818Biochemical and molecular characterization of diseases linked to motor proteins
Q36996595Biology of epidermal and hair pigmentation in cattle: a mini-review
Q35956753Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a
Q24648345Cargos and genes: insights into vesicular transport from inherited human disease
Q34171093Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome
Q48073436Chloroplast outer envelope protein CHUP1 is essential for chloroplast anchorage to the plasma membrane and chloroplast movement
Q47294747Consequences of Rab GTPase dysfunction in genetic or acquired human diseases
Q59357525Creation of a myosin Va-TAP-tagged mouse and identification of potential myosin Va-interacting proteins in the cerebellum
Q36372754Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses
Q35116674Delivering the kiss of death
Q35558454Do disorders of movement cause movement disorders and dementia?
Q37425630Dominant-negative myosin Va impairs retrograde but not anterograde axonal transport of large dense core vesicles
Q100503861Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
Q88991793Engaging myosin VI tunes motility, morphology and identity in endocytosis
Q78363435Formation of mutually exclusive Rab11 complexes with members of the family of Rab11-interacting proteins regulates Rab11 endocytic targeting and function
Q37604660Genome-wide identification, splicing, and expression analysis of the myosin gene family in maize (Zea mays).
Q36328341Glucose-sensing mechanisms in pancreatic beta-cells.
Q28115572Human Myo19 is a novel myosin that associates with mitochondria
Q24322633Identification and characterization of multiple novel Rab-myosin Va interactions
Q28910206Identification of a minimal myosin Va binding site within an intrinsically unstructured domain of melanophilin
Q27939242Identification of an organelle-specific myosin V receptor
Q36322129Identification of the membrane receptor of a class XIV myosin in Toxoplasma gondii
Q47171809Interleukin-22 participates in the inflammatory process of vitiligo
Q35826372Involvement of vps33a in the fusion of uroplakin-degrading multivesicular bodies with lysosomes
Q46359364Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cells
Q49026698Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes
Q26828461Lysosome-Related Effector Vesicles in T Lymphocytes and NK Cells
Q35679335Melanophilin Stimulates Myosin-5a Motor Function by Allosterically Inhibiting the Interaction between the Head and Tail of Myosin-5a
Q28507496Melanophilin and myosin Va track the microtubule plus end on EB1
Q36226837Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis
Q35153478Membrane targeting of Rab GTPases is influenced by the prenylation motif
Q48853478Molecular mechanism of myosin Va recruitment to dense core secretory granules
Q37226089More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va
Q46568450Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family.
Q92351638Myosin V regulates synaptopodin clustering and localization in the dendrites of hippocampal neurons
Q40391038Myosin VIIB from Drosophila is a high duty ratio motor
Q64077575Myosin Va and spermine synthase: partners in exosome transport
Q28589310Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells
Q33810384Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro.
Q24304047Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells
Q39824158Myosin Vb localises to nucleoli and associates with the RNA polymerase I transcription complex.
Q37021389Myosin light chains: Teaching old dogs new tricks
Q34580378Myosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomes
Q34187072Nanometer localization of single green fluorescent proteins: evidence that myosin V walks hand-over-hand via telemark configuration
Q37361948New insights into melanosome transport in vertebrate pigment cells.
Q50656177Opposite effects of overexpressed myosin Va or heavy meromyosin Va on vesicle distribution, cytoskeleton organization, and cell motility in nonmuscle cells
Q36445255Organelles on the move: insights from yeast vacuole inheritance
Q35564835Pigment Cells: A Model for the Study of Organelle Transport
Q38388053Rab family of GTPases.
Q37768044Rab protein evolution and the history of the eukaryotic endomembrane system
Q35548944Rab proteins and the compartmentalization of the endosomal system
Q24297100Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes
Q24561595Rab22a regulates the recycling of membrane proteins internalized independently of clathrin
Q40492183Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.
Q40211013Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes
Q33714453Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes
Q24303445Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts
Q51767228Rab35 regulates neurite outgrowth and cell shape.
Q34815289Rac and rho: the story behind melanocyte dendrite formation
Q39449551Regulation of class V myosin.
Q27438136Role of Myosin Va in the plasticity of the vertebrate neuromuscular junction in vivo
Q34392475Role of the lever arm in the processive stepping of myosin V.
Q38061997Roles for myosin Va in RNA transport and turnover.
Q28585075Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6
Q36445367Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.
Q36945947Suppression of antifolate resistance by targeting the myosin Va trafficking pathway in melanoma.
Q34145357Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A.
Q44420447The Inhibition of Early N-Glycan Processing Targets TRP-2 to Degradation in B16 Melanoma Cells
Q34867624The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling
Q36805329The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini
Q34214082The color loci of mice--a genetic century
Q36446088The globular tail domain puts on the brake to stop the ATPase cycle of myosin Va.
Q28589486The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells
Q64039609The road to LROs: insights into lysosome-related organelles from Hermansky-Pudlak syndrome and other rare diseases
Q35985156The role of membranes and membrane trafficking in RNA localization
Q38151847The role of the cytoskeleton at the immunological synapse
Q37035339The tail that wags the dog: the globular tail domain defines the function of myosin V/XI.
Q30479761The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium
Q37297090Tropomyosin isoforms bias actin track selection by vertebrate myosin Va
Q30482261Truncated myosin XI tail fusions inhibit peroxisome, Golgi, and mitochondrial movement in tobacco leaf epidermal cells: a genetic tool for the next generation
Q30833080Two pathways regulate cortical granule translocation to prevent polyspermy in mouse oocytes
Q92156441Unconventional Myosins: How Regulation Meets Function
Q34238805Walking to work: roles for class V myosins as cargo transporters
Q36821161Zebrafish melanophilin facilitates melanosome dispersion by regulating dynein

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