Unconventional Myosins: How Regulation Meets Function

scientific article published on 20 December 2019

Unconventional Myosins: How Regulation Meets Function is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/IJMS21010067
P932PMC publication ID6981383
P698PubMed publication ID31861842

P50authorNatalia FiliQ92156436
Christopher P. ToselandQ49406828
P2860cites workActivation of myosin Va function by melanophilin, a specific docking partner of myosin VaQ81508526
The actin-binding interface of a myosin III is phosphorylated in vivo in response to signals from a circadian clockQ81571539
Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clusteringQ82457987
Three-dimensional structure of the myosin V inhibited state by cryoelectron tomographyQ83177861
Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular functionQ91343838
Kinetics of the interaction of myo1c with phosphoinositidesQ37431105
Myosin VI rewrites the rules for myosin motorsQ37755563
Principles of unconventional myosin function and targetingQ37884613
Nuclear actin and myosins: life without filamentsQ37952090
Myosin VI and its cargo adaptors - linking endocytosis and autophagyQ38115519
Cargo recognition and cargo-mediated regulation of unconventional myosinsQ38250419
Structural Basis of Cargo Recognition by Unconventional Myosins in Cellular TraffickingQ38722191
How Myosin Generates Force on Actin FilamentsQ38975414
Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cellsQ39735805
Myosin Va phosphorylated on Ser1650 is found in nuclear speckles and redistributes to nucleoli upon inhibition of transcriptionQ40004114
Alternatively spliced exon B of myosin Va is essential for binding the tail-associated light chain shared by dyneinQ40222323
The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motorQ40270903
MYO6 is targeted by Salmonella virulence effectors to trigger PI3-kinase signaling and pathogen invasion into host cells.Q40276496
TEDS rule: a molecular rationale for differential regulation of myosins by phosphorylation of the heavy chain headQ40410613
A monomeric myosin VI with a large working strokeQ40573331
Ca2+-induced activation of ATPase activity of myosin Va is accompanied with a large conformational changeQ40587730
Class VI myosin moves processively along actin filaments backward with large stepsQ40758767
The localization and sequence of the phosphorylation sites of Acanthamoeba myosins I. An improved method for locating the phosphorylated amino acidQ41266974
Myosin I can act as a molecular force sensor.Q41334383
The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11.Q41998305
Kinetic properties and small-molecule inhibition of human myosin-6.Q42032109
Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle.Q42073159
Comparative kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoformsQ42093317
Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2.Q42155473
Phosphorylation of the kinase domain regulates autophosphorylation of myosin IIIA and its translocation in microvilliQ42173398
The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.Q42323966
Membrane-bound myo1c powers asymmetric motility of actin filamentsQ42554416
Effect of phosphorylation in the motor domain of human myosin IIIA on its ATP hydrolysis cycleQ43146291
Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1.Q43266175
Kinetic mechanism and regulation of myosin VI.Q43651972
Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II.Q43710205
Crosstalk between PI(4,5)P₂and CK2 modulates actin polymerization during endocytic uptakeQ44110982
Calcium functionally uncouples the heads of myosin VI.Q44394472
The mechanism of myosin VI translocation and its load-induced anchoringQ44790017
Magnesium regulates ADP dissociation from myosin V.Q45173714
Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosinQ45173722
A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.Q45712448
Myosin VI altered at threonine 406 stabilizes actin filaments in vivoQ46044406
She3p binds to the rod of yeast myosin V and prevents it from dimerizing, forming a single-headed motor complexQ46822902
Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosisQ46917024
Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafishQ47073856
NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription.Q47140521
Regulated conformation of myosin V.Q47368896
Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosisQ47991408
Myosin-1C uses a novel phosphoinositide-dependent pathway for nuclear localizationQ48251880
Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged MitochondriaQ49339871
Ca2+-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single α Helix Lever Arm Extension.Q51110298
Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational couplingQ52159623
Phospholipid-dependent regulation of the motor activity of myosin X.Q52612413
The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head.Q52857621
A tissue-specific exon of myosin Va is responsible for selective cargo binding in melanocytes.Q53788055
The motor protein myosin-I produces its working stroke in two stepsQ56894963
Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule levelQ61135840
Brain myosin-V is a two-headed unconventional myosin with motor activityQ70488210
The interaction of F-actin with phosphorylated and unphosphorylated myosins IA and IB from Acanthamoeba castellaniiQ72559861
Kinetic analyses of a truncated mammalian myosin I suggest a novel isomerization event preceding nucleotide bindingQ73712699
Localization of myosin-Ibeta near both ends of tip links in frog saccular hair cellsQ77458696
Myosin Va becomes a low duty ratio motor in the inhibited formQ79960802
The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domainQ80280712
Effect of calcium on calmodulin bound to the IQ motifs of myosin VQ80465025
Motility of myosin V regulated by the dissociation of single calmodulinQ81308489
Myosin va mediates docking of secretory granules at the plasma membraneQ81358009
Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 speciesQ21092862
The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulationQ22008538
Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosisQ24291429
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomesQ24294793
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transportQ24295585
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosisQ24300284
Myo1e binds anionic phospholipids with high affinityQ24300535
Nuclear myosin VI enhances RNA polymerase II-dependent transcriptionQ24301373
A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expressionQ24305683
Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticityQ24336738
Rab27a is an essential component of melanosome receptor for myosin VaQ24524137
Myosin VI is a processive motor with a large step sizeQ24555089
Myo1c is designed for the adaptation response in the inner earQ24610102
A millennial myosin censusQ24633678
T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesionQ24650918
Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticityQ24655632
Identification, characterization and cloning of myr 1, a mammalian myosin-IQ24674123
Calcium can mobilize and activate myosin-VIQ27317433
Precise positioning of myosin VI on endocytic vesicles in vivoQ27334526
Myosin VI Dimerization Triggers an Unfolding of a Three-Helix Bundle in Order to Extend Its ReachQ27656923
Myosin VI undergoes cargo-mediated dimerizationQ27656929
Antiparallel coiled-coil-mediated dimerization of myosin XQ27673659
Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensorQ27674679
Structural basis of cargo recognitions for class V myosinsQ27678783
Structural basis of myosin V Rab GTPase-dependent cargo recognitionQ27680629
A vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuningQ27681483
Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 bindingQ27689527
Human myosin V gene produces different transcripts in a cell type-specific mannerQ28117452
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transportQ28202672
Coupled myosin VI motors facilitate unidirectional movement on an F-actin networkQ37387839
Transient kinetic analysis of the 130-kDa myosin I (MYR-1 gene product) from rat liver. A myosin I designed for maintenance of tension?Q28369644
Identification of an organelle receptor for myosin-VaQ28504759
Molecular genetic dissection of mouse unconventional myosin-VA: tail region mutationsQ28507012
Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesiclesQ28511953
Mouse class III myosins: kinase activity and phosphorylation sitesQ28512769
Localization of myosin 1b to actin protrusions requires phosphoinositide bindingQ28566730
Biochemical and motile properties of Myo1b splice isoformsQ28570970
Control of myosin-I force sensing by alternative splicingQ28577567
Regulation of myosin-VI targeting to endocytic compartmentsQ28580721
Role of myosin VI in the differentiation of cochlear hair cellsQ28585164
Novel myosin heavy chain encoded by murine dilute coat colour locusQ28590446
Retroviral sequences located within an intron of the dilute gene alter dilute expression in a tissue-specific mannerQ28592127
Localization of ASH1 mRNA particles in living yeastQ29614818
A FERM domain autoregulates Drosophila myosin 7a activityQ30157340
Fast adaptation in vestibular hair cells requires myosin-1c activityQ30437793
Myo1c binds phosphoinositides through a putative pleckstrin homology domainQ30478257
Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.Q30479902
Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner earQ30481688
Control of cell membrane tension by myosin-I.Q30489048
Cargo binding activates myosin VIIA motor function in cellsQ30499937
Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actinQ30534452
Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathwayQ30592846
TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p.Q33233910
Myosin-Vb functions as a dynamic tether for peripheral endocytic compartments during transferrin traffickingQ33358549
Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH).Q33726416
Cloning and chromosomal localization of a human class III myosinQ33913130
Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.Q33917620
Leveraging the membrane - cytoskeleton interface with myosin-1.Q33965456
Evidence that myosin activity opposes microtubule-based axonal transport of mitochondriaQ33998992
Myosin VI: roles for a minus end-directed actin motor in cellsQ34038023
Dual regulation of mammalian myosin VI motor functionQ34087728
Human myosin-Vc is a novel class V myosin expressed in epithelial cellsQ34116426
Magnesium modulates actin binding and ADP release in myosin motorsQ34141150
Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A).Q34199087
Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles.Q34285278
Nucleotide-Dependent Shape Changes in the Reverse Direction Motor, Myosin VIQ34307078
Melanosomes transported by myosin-V in Xenopus melanophores perform slow 35 nm stepsQ34352932
Role of the lever arm in the processive stepping of myosin V.Q34392475
Kinetic mechanism of human myosin IIIA.Q34577832
Mutational spectrum of MYO15A: the large N-terminal extension of myosin XVA is required for hearing.Q34634062
Myosin VI stabilizes an actin network during Drosophila spermatid individualizationQ34662188
Myo3A, one of two class III myosin genes expressed in vertebrate retina, is localized to the calycal processes of rod and cone photoreceptors and is expressed in the sacculusQ34813453
New insights into myosin evolution and classificationQ34944007
Myosin-X: a MyTH-FERM myosin at the tips of filopodiaQ35576442
Two single-headed myosin V motors bound to a tetrameric adapter protein form a processive complexQ35670601
Melanophilin Stimulates Myosin-5a Motor Function by Allosterically Inhibiting the Interaction between the Head and Tail of Myosin-5aQ35679335
The cargo-binding domain regulates structure and activity of myosin 5Q35752269
Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocationQ35949606
Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5aQ35956753
p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin IQ35987694
Myo4p is a monomeric myosin with motility uniquely adapted to transport mRNAQ36119329
Myosin VI and vinculin cooperate during the morphogenesis of cadherin cell cell contacts in mammalian epithelial cellsQ36119767
Membrane-induced lever arm expansion allows myosin VI to walk with large and variable step sizesQ36318743
Visualization of melanosome dynamics within wild-type and dilute melanocytes suggests a paradigm for myosin V function In vivoQ36328552
The globular tail domain puts on the brake to stop the ATPase cycle of myosin Va.Q36446088
Long single alpha-helical tail domains bridge the gap between structure and function of myosin VI.Q36740061
Various Themes of Myosin RegulationQ36880297
Class VI unconventional myosin is required for spermatogenesis in DrosophilaQ36956898
Loop 2 of limulus myosin III is phosphorylated by protein kinase A and autophosphorylationQ36966889
Myosin light chains: Teaching old dogs new tricksQ37021389
Alternative splicing in class V myosins determines association with Rab10.Q37036487
Single-molecule reconstitution of mRNA transport by a class V myosinQ37076266
Diverse functions of myosin VI elucidated by an isoform-specific α-helix domainQ37135682
The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIAQ37208900
More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin VaQ37226089
Calmodulin in complex with the first IQ motif of myosin-5a functions as an intact calcium sensor.Q37323208
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P577publication date2019-12-20
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleUnconventional Myosins: How Regulation Meets Function
P478volume21

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cites work (P2860)
Q110697472Dynamics of the orphan myosin MyoF over Trypanosoma cruzi life cycle and along the endocytic pathway
Q101403005Nonmuscle myosin IIB regulates Parkin-mediated mitophagy associated with amyotrophic lateral sclerosis-linked TDP-43

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