Cargo binding activates myosin VIIA motor function in cells

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Cargo binding activates myosin VIIA motor function in cells is …
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scholarly articleQ13442814

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P819ADS bibcode2011PNAS..108.7028S
P356DOI10.1073/PNAS.1009188108
P932PMC publication ID3084129
P698PubMed publication ID21482763
P5875ResearchGate publication ID51041558

P50authorMitsuo IkebeQ103836858
P2093author name stringNobuhisa Umeki
Reiko Ikebe
Tsuyoshi Sakai
P2860cites workMyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomesQ24294793
Defective myosin VIIA gene responsible for Usher syndrome type 1BQ24314638
Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1BQ24562934
Alanine scanning mutagenesis of the switch I region in the ATPase site of Dictyostelium discoideum myosin IIQ73879827
Melanosomes of retinal pigment epithelium--distribution, shape, and acid phosphatase activityQ77209513
Effects of mutations in the gamma-phosphate binding site of myosin on its motor functionQ77387714
Myosin VI undergoes cargo-mediated dimerizationQ27656929
Mutations in the myosin VIIA gene cause non-syndromic recessive deafnessQ28239749
The autosomal recessive isolated deafness, DFNB2, and the Usher 1B syndrome are allelic defects of the myosin-VIIA geneQ28239757
ARPE-19, a human retinal pigment epithelial cell line with differentiated propertiesQ28283979
Molecular cloning and domain structure of human myosin-VIIa, the gene product defective in Usher syndrome 1BQ28294301
The structural basis of myosin V processive movement as revealed by electron cryomicroscopyQ28509931
Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actinQ28584753
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cellsQ28594091
A structural change in the kinesin motor protein that drives motilityQ29617533
A FERM domain autoregulates Drosophila myosin 7a activityQ30157340
Dimerized Drosophila myosin VIIa: a processive motorQ30477237
The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epitheliumQ30479761
The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.Q30480576
Myosin VI undergoes a 180 degrees power stroke implying an uncoupling of the front lever arm.Q30491564
Impacts of Usher syndrome type IB mutations on human myosin VIIa motor functionQ33649335
Contribution of the myosin VI tail domain to processive stepping and intramolecular tension sensingQ33842753
Myosin-X is an unconventional myosin that undergoes intrafilopodial motility.Q34115035
Role of the lever arm in the processive stepping of myosin V.Q34392475
Myosin-V stepping kinetics: a molecular model for processivityQ35207228
Distinct conformations of the kinesin Unc104 neck regulate a monomer to dimer motor transitionQ36324862
The molecular regulation of organelle transport in mammalian retinal pigment epithelial cellsQ36416475
The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIAQ37208900
Cargo binding induces dimerization of myosin VI.Q37366472
Coupled myosin VI motors facilitate unidirectional movement on an F-actin networkQ37387839
The SAH domain extends the functional length of the myosin leverQ37477144
A new look at the microtubule binding patterns of dimeric kinesinsQ39534405
Functional significance of the conserved residues in the flexible hinge region of the myosin motor domainQ42058592
Myosin VI walks "wiggly" on actin with large and variable tiltingQ42149706
Analysis of the linkage of MYRIP and MYO7A to melanosomes by RAB27A in retinal pigment epithelial cellsQ42163341
Video imaging of walking myosin V by high-speed atomic force microscopy.Q42863053
Neck length and processivity of myosin V.Q44436395
Conversion of Unc104/KIF1A kinesin into a processive motor after dimerizationQ46222071
Functional analysis of Slac2-c/MyRIP as a linker protein between melanosomes and myosin VIIa.Q46520725
Drosophila myosin VIIA is a high duty ratio motor with a unique kinetic mechanismQ46895770
Identification of a new mutation of the myosin VII head region in Usher syndrome type 1.Q50511522
Myosin VIIa, the product of the Usher 1B syndrome gene, is concentrated in the connecting cilia of photoreceptor cells.Q50511568
Rab7 and Rab27a control two motor protein activities involved in melanosomal transportQ63406991
Site-directed mutagenesis of double-stranded DNA by the polymerase chain reactionQ72427121
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)7028-7033
P577publication date2011-04-11
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleCargo binding activates myosin VIIA motor function in cells
P478volume108