The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.

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The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation. is …
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scholarly articleQ13442814

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P356DOI10.1083/JCB.200703178
P932PMC publication ID2064759
P698PubMed publication ID17954606
P5875ResearchGate publication ID5890399

P50authorHiroshi TokuoQ73349868
Mitsuo IkebeQ103836858
P2093author name stringKatsuhide Mabuchi
P2860cites workMyosin-X is a molecular motor that functions in filopodia formationQ24299253
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860608
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860628
Cell migration: integrating signals from front to backQ27860670
Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeletonQ28235021
Myosin X regulates netrin receptors and functions in axonal path-findingQ28506167
Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neuronsQ28507574
Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localizationQ29615477
Mechanism of filopodia initiation by reorganization of a dendritic networkQ29616648
Myosin X transports Mena/VASP to the tip of filopodia.Q31065358
Cascade pathway of filopodia formation downstream of SCAR.Q33197463
Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.Q33917620
Myosin-X is an unconventional myosin that undergoes intrafilopodial motility.Q34115035
Myosin-X provides a motor-based link between integrins and the cytoskeleton.Q34322246
Role of the lever arm in the processive stepping of myosin V.Q34392475
Calmodulin-like protein increases filopodia-dependent cell motility via up-regulation of myosin-10.Q34585084
Imaging myosin 10 in cellsQ35922809
Myosin-X: a molecular motor at the cell's fingertipsQ36248392
The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motorQ40270903
IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of MenaQ40649467
Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice.Q40689739
Cytoskeletal events in growth cone steeringQ40748281
Functional significance of the conserved residues in the flexible hinge region of the myosin motor domainQ42058592
Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2.Q42155473
Mutational analysis of the switch II loop of Dictyostelium myosin II.Q42459018
Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarityQ43108576
The gated gait of the processive molecular motor, myosin V.Q43820585
Heavy-meromyosin-decorated actin filaments: A simple method to preserve actin filaments for rotary shadowingQ44760367
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.Q44831766
Myosin X is a high duty ratio motorQ46551350
A microtubule-binding myosin required for nuclear anchoring and spindle assembly.Q52560093
The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head.Q52857621
Melting of myosin and tropomyosin: electron microscopic observationsQ68636156
Alanine scanning mutagenesis of the switch I region in the ATPase site of Dictyostelium discoideum myosin IIQ73879827
Effects of mutations in the gamma-phosphate binding site of myosin on its motor functionQ77387714
Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clusteringQ82457987
P433issue2
P407language of work or nameEnglishQ1860
P1104number of pages10
P304page(s)229-238
P577publication date2007-10-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleThe motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation
P478volume179

Reverse relations

cites work (P2860)
Q30826156A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip
Q30635372A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast
Q30482736A myosin motor that selects bundled actin for motility
Q41978648A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule level
Q51730379AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica.
Q30496157Actin cross-link assembly and disassembly mechanics for alpha-Actinin and fascin
Q24611930Actin in dendritic spines: connecting dynamics to function
Q30841590Activated full-length myosin-X moves processively on filopodia with large steps toward diverse two-dimensional directions
Q27673659Antiparallel coiled-coil-mediated dimerization of myosin X
Q30499937Cargo binding activates myosin VIIA motor function in cells
Q27666969Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain
Q43004259Class XI myosins are required for development, cell expansion, and F-Actin organization in Arabidopsis
Q45093732Cloning, characterization, and promoter analysis of mouse Myo10 gene
Q30514794Differential regulation of myosin X movements by its cargos, DCC and neogenin.
Q34512374Distinct tissue distributions and subcellular localizations of differently phosphorylated forms of the myosin regulatory light chain in Drosophila
Q24646242Dynamic length regulation of sensory stereocilia
Q26823315Filopodia and adhesion in cancer cell motility
Q41601984Filopodia formation by crosslinking of F-actin with fascin in two different binding manners.
Q93893038Filopodia motor ahead
Q28279460Filopodia: molecular architecture and cellular functions
Q36127036Headless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons
Q42380606Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions
Q34285278Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles.
Q37339182Involvement of headless myosin X in the motility of immortalized gonadotropin-releasing hormone neuronal cells
Q42819566Lamellipodia nucleation by filopodia depends on integrin occupancy and downstream Rac1 signaling
Q28743071Lever-arm mechanics of processive myosins
Q46367877Linking actin networks and cell membrane via a reaction-diffusion-elastic description of nonlinear filopodia initiation
Q39917139Modulation of cell motility by spatial repositioning of enzymatic ATP/ADP exchange capacity
Q30572690Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.
Q37515120MyTH4-FERM myosins have an ancient and conserved role in filopod formation
Q39005661MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions
Q30490501Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments
Q38962635Myosin VI must dimerize and deploy its unusual lever arm in order to perform its cellular roles.
Q36378456Myosin X dimerization and its impact on cellular functions
Q42652879Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation
Q89545561Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis
Q34985570Myosin motor function: the ins and outs of actin-based membrane protrusions.
Q30482632Myosin-10 and actin filaments are essential for mitotic spindle function
Q37245779Myosin-10 independently influences mitotic spindle structure and mitotic progression
Q26825835Myosin-X and disease
Q30513859Myosin-X functions in polarized epithelial cells
Q30494868Myosin-X induces filopodia by multiple elongation mechanism
Q30576361Myosin-X is critical for migratory ability of Xenopus cranial neural crest cells.
Q47139973Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation.
Q35576442Myosin-X: a MyTH-FERM myosin at the tips of filopodia
Q44619260One step ahead: role of filopodia in adhesion formation during cell migration of keratinocytes
Q90702016Optimized filopodia formation requires myosin tail domain cooperation
Q52612413Phospholipid-dependent regulation of the motor activity of myosin X.
Q37884613Principles of unconventional myosin function and targeting
Q34590671Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay
Q41047666ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain.
Q24319871Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization
Q58104023Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly
Q39177650S100A4 downregulates filopodia formation through increased dynamic instability
Q90737023Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells
Q30663513Self-organization of waves and pulse trains by molecular motors in cellular protrusions
Q89816880Simultaneous tracking of two motor domains reveals near simultaneous steps and stutter steps of myosin 10 on actin filament bundles
Q30494681Single-molecule stepping and structural dynamics of myosin X.
Q24305586Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain
Q27674679Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor
Q88202227The Antiparallel Dimerization of Myosin X Imparts Bundle Selectivity for Processive Motility
Q34134758The Stepping Pattern of Myosin X Is Adapted for Processive Motility on Bundled Actin
Q30493646The motor protein myosin-X transports VE-cadherin along filopodia to allow the formation of early endothelial cell-cell contacts.
Q27333243The myosin X motor is optimized for movement on actin bundles
Q41825148The path to visualization of walking myosin V by high-speed atomic force microscopy
Q94465899Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease
Q30488428Unconventional myosin traffic in cells reveals a selective actin cytoskeleton
Q36929781Unconventional myosins acting unconventionally.

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