MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions

scientific article published on 8 November 2016

MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.CEB.2016.10.002
P932PMC publication ID5403704
P698PubMed publication ID27836411

P50authorMatthew John TyskaQ90406485
P2093author name stringNathan E Grega-Larson
Meredith L Weck
P2860cites workEPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafnessQ21202842
Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilliQ22003897
Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesionQ24294411
A new role for the architecture of microvillar actin bundles in apical retention of membrane proteinsQ24298199
Myosin-X is a molecular motor that functions in filopodia formationQ24299253
Structural basis of cargo recognition by the myosin-X MyTH4-FERM domainQ24305586
Defective myosin VIIA gene responsible for Usher syndrome type 1BQ24314638
Twinfilin 2 regulates actin filament lengths in cochlear stereociliaQ24324361
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundleQ24337137
CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASPQ24337450
MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cellsQ24537500
The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactionsQ24538474
Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1BQ24562934
TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner earQ24599460
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.Q44831766
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegansQ45159078
The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia.Q46503087
Functional analysis of Slac2-c/MyRIP as a linker protein between melanosomes and myosin VIIa.Q46520725
Myosin X is a high duty ratio motorQ46551350
Drosophila myosin VIIA is a high duty ratio motor with a unique kinetic mechanismQ46895770
Actin filaments, stereocilia, and hair cells of the bird cochlea. IV. How the actin filaments become organized in developing stereocilia and in the cuticular plate.Q52261039
A microtubule-binding myosin required for nuclear anchoring and spindle assembly.Q52560093
PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation.Q52604153
Phospholipid-dependent regulation of the motor activity of myosin X.Q52612413
Actin filaments, stereocilia, and hair cells of the bird cochlea. III. The development and differentiation of hair cells and stereocilia.Q53757897
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1Q57184595
Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assemblyQ57899443
Actin filaments, stereocilia and hair cells of the bird cochlea. VI. How the number and arrangement of stereocilia are determinedQ67988113
Immunoelectron microscopic and immunofluorescent localization of cytoskeletal and muscle-like contractile proteins in inner ear sensory hair cellsQ69925621
A role for myosin VII in dynamic cell adhesionQ73670214
Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasisQ33994291
Helical arrangement of filaments in microvillar actin bundlesQ34074964
Myosin-X is an unconventional myosin that undergoes intrafilopodial motility.Q34115035
Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein traffickingQ34120199
The Stepping Pattern of Myosin X Is Adapted for Processive Motility on Bundled ActinQ34134758
Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2Q34144378
A gene for congenital, recessive deafness DFNB3 maps to the pericentromeric region of chromosome 17.Q34307634
Myosin-X provides a motor-based link between integrins and the cytoskeleton.Q34322246
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complexQ34334221
The physics of filopodial protrusionQ34350863
VASP is a processive actin polymerase that requires monomeric actin for barbed end associationQ34412426
Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3.Q34469642
Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cellsQ34680349
The kinetic mechanism of mouse myosin VIIAQ34685505
Structure and Regulation of the Movement of Human Myosin VIIA.Q35837241
Myosin X regulates neuronal radial migration through interacting with N-cadherinQ35964174
TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell StereociliaQ36057785
Role of fascin in filopodial protrusionQ36118593
The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearingQ36119739
Formins and VASPs may co-operate in the formation of filopodia.Q36295378
Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retractionQ36316633
Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo.Q36324725
Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptorsQ36639095
Myosin MyTH4-FERM structures highlight important principles of convergent evolution.Q36957296
PDZD7-MYO7A complex identified in enriched stereocilia membranes.Q37217653
Villin: The major microfilament-associated protein of the intestinal microvillusQ37330654
Filopodia initiation: focus on the Arp2/3 complex and forminsQ37942763
The cuticular plate: a riddle, wrapped in a mystery, inside a hair cellQ38536077
Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxisQ40286969
Myosin VIIB from Drosophila is a high duty ratio motorQ40391038
XIRP2, an actin-binding protein essential for inner ear hair-cell stereociliaQ41220564
Fimbrin, a new microfilament-associated protein present in microvilli and other cell surface structuresQ41270803
The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cellsQ41865648
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule levelQ41978648
Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar Adhesion ComplexQ42365129
Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene.Q42455765
Dynamical control of the shape and size of stereocilia and microvilliQ42468948
Impact of cordon-bleu expression on actin cytoskeleton architecture and dynamicsQ42760014
The Rho family GTPase Rif induces filopodia through mDia2.Q42818923
Cargo binding activates myosin VIIA motor function in cellsQ30499937
Differential regulation of myosin X movements by its cargos, DCC and neogenin.Q30514794
Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereociliaQ30525334
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.Q30572690
Cofilin cooperates with fascin to disassemble filopodial actin filamentsQ30581893
Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in miceQ30607162
Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear.Q30644335
Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins.Q30659759
A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial TipQ30826156
Myosin X transports Mena/VASP to the tip of filopodia.Q31065358
Vertebrate myosin VIIb is a high duty ratio motor adapted for generating and maintaining tensionQ33223992
The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cellsQ33911618
A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C geneQ33916587
Fascin 2b is a component of stereocilia that lengthens actin-based protrusionsQ33916876
Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.Q33917620
An actin molecular treadmill and myosins maintain stereocilia functional architecture and self-renewalQ24676711
Organization of actin, myosin, and intermediate filaments in the brush border of intestinal epithelial cellsQ24681056
Cordon bleu promotes the assembly of brush border microvilliQ27305309
Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin CloudsQ27314555
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.Q27317317
Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cellsQ27321482
The myosin X motor is optimized for movement on actin bundlesQ27333243
Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23Q27654205
The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteinsQ27659663
Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargoQ27666702
Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domainQ27666969
Antiparallel coiled-coil-mediated dimerization of myosin XQ27673659
Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link ComplexQ27703731
Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2Q28115357
ANKS4B Is Essential for Intermicrovillar Adhesion Complex FormationQ28115836
Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42Q28188673
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
Mutations in the myosin VIIA gene cause non-syndromic recessive deafnessQ28239749
Autosomal dominant non-syndromic deafness caused by a mutation in the myosin VIIA geneQ28253373
PIP3, PIP2, and cell movement--similar messages, different meanings?Q28366133
Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8Q28504869
Myosin X regulates netrin receptors and functions in axonal path-findingQ28506167
Myosin VIIa participates in opsin transport through the photoreceptor ciliumQ28509436
Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cellsQ28509764
A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cellsQ28510477
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioningQ28513848
Characterization of the motor activity of mammalian myosin VIIAQ28566322
Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransductionQ28569812
Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutationsQ28586011
The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J miceQ28586440
Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epitheliumQ28588267
The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles.Q28589815
Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31Q28590107
Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directlyQ28590821
Mutant myosin VIIa causes defective melanosome distribution in the RPE of shaker-1 miceQ28591690
Mutation analysis of the mouse myosin VIIA deafness geneQ28592197
Interactions in the network of Usher syndrome type 1 proteinsQ28592874
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomesQ28593151
Eps8 controls actin-based motility by capping the barbed ends of actin filamentsQ28593794
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereociliaQ28593953
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assemblyQ28609843
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in miceQ28748684
Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.Q29347270
Mechanism of filopodia initiation by reorganization of a dendritic networkQ29616648
Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motilityQ29618423
Cordon Bleu serves as a platform at the basal region of microvilli, where it regulates microvillar length through its WH2 domainsQ30009349
A FERM domain autoregulates Drosophila myosin 7a activityQ30157340
Myosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia.Q30168113
A short splice form of Xin-actin binding repeat containing 2 (XIRP2) lacking the Xin repeats is required for maintenance of stereocilia morphology and hearing functionQ30300856
ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulinQ30435772
Ena/VASP proteins have an anti-capping independent function in filopodia formationQ30444426
β-Actin and fascin-2 cooperate to maintain stereocilia lengthQ30447400
Dimerized Drosophila myosin VIIa: a processive motorQ30477237
The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epitheliumQ30479761
Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipidsQ30479852
Gelsolin plays a role in the actin polymerization complex of hair cell stereociliaQ30480367
The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.Q30480576
Myosin-10 and actin filaments are essential for mitotic spindle functionQ30482632
A myosin motor that selects bundled actin for motilityQ30482736
Unconventional myosin traffic in cells reveals a selective actin cytoskeletonQ30488428
Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filamentsQ30490501
Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundleQ30493544
The motor protein myosin-X transports VE-cadherin along filopodia to allow the formation of early endothelial cell-cell contacts.Q30493646
Actin filaments, stereocilia, and hair cells of the bird cochlea. V. How the staircase pattern of stereociliary lengths is generatedQ30494574
Actin filaments, stereocilia, and hair cells of the bird cochlea. II. Packing of actin filaments in the stereocilia and in the cuticular plate and what happens to the organization when the stereocilia are bentQ30494582
Actin filaments, stereocilia, and hair cells of the bird cochlea. I. Length, number, width, and distribution of stereocilia of each hair cell are related to the position of the hair cell on the cochleaQ30494583
Single-molecule stepping and structural dynamics of myosin X.Q30494681
Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearingQ30494750
P304page(s)68-78
P577publication date2016-11-08
P1433published inCurrent Opinion in Cell BiologyQ13505682
P1476titleMyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions
P478volume44

Reverse relations

cites work (P2860)
Q58805948A novel nonsense mutation in MYO15A is associated with non-syndromic hearing loss: a case report
Q47139973Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation.
Q89228311Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth
Q90702016Optimized filopodia formation requires myosin tail domain cooperation
Q43058873Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.

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