Headless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons

scientific article

Headless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.369173
P932PMC publication ID3408153
P698PubMed publication ID22661706

P50authorRichard CheneyQ42703433
P2093author name stringAlexander N Raines
Michael L Kerber
Sarbajeet Nagdas
P2860cites workMyosin-X is a molecular motor that functions in filopodia formationQ24299253
Structural basis of cargo recognition by the myosin-X MyTH4-FERM domainQ24305586
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Actin in dendritic spines: connecting dynamics to functionQ24611930
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beta1 integrin maintains integrity of the embryonic neocortical stem cell nicheQ27329520
Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domainQ27666969
Myosin X is a downstream effector of PI(3)K during phagocytosisQ28114999
Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowthQ28211919
Filopodia: molecular architecture and cellular functionsQ28279460
Cerebellum development and medulloblastomaQ28304753
Myosin X regulates netrin receptors and functions in axonal path-findingQ28506167
Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neuronsQ28507574
LKB1 and SAD kinases define a pathway required for the polarization of cortical neuronsQ28591764
Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent mannerQ30479119
The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.Q30480576
Myosin-10 and actin filaments are essential for mitotic spindle functionQ30482632
The motor protein myosin-X transports VE-cadherin along filopodia to allow the formation of early endothelial cell-cell contacts.Q30493646
Structured post-IQ domain governs selectivity of myosin X for fascin-actin bundlesQ30496161
Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodiaQ30496687
Myosin-X is required for cranial neural crest cell migration in Xenopus laevisQ30497957
Differential regulation of myosin X movements by its cargos, DCC and neogenin.Q30514794
Myosin-X is critical for migratory ability of Xenopus cranial neural crest cells.Q30576361
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous systemQ33239286
Automated analysis of NeuronJ tracing dataQ33378159
Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.Q33917620
Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidanceQ33996728
Common mechanisms underlying growth cone guidance and axon branchingQ33996741
Myosin-X is an unconventional myosin that undergoes intrafilopodial motility.Q34115035
Myosin-X provides a motor-based link between integrins and the cytoskeleton.Q34322246
The dynamic cytoskeleton: backbone of dendritic spine plasticityQ34441669
The growth cone cytoskeleton in axon outgrowth and guidance.Q34577996
Calmodulin-like protein increases filopodia-dependent cell motility via up-regulation of myosin-10.Q34585084
Vertebrate MAX-1 is required for vascular patterning in zebrafishQ35130734
Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosumQ35215714
Myosin-X: a MyTH-FERM myosin at the tips of filopodiaQ35576442
Spindle position in symmetric cell divisions during epiboly is controlled by opposing and dynamic apicobasal forcesQ35903531
Touch and go: guidance cues signal to the growth cone cytoskeletonQ36249464
Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptorsQ36639095
Mechanisms of asymmetric stem cell divisionQ37092865
Ena/VASP: proteins at the tip of the nervous systemQ37174967
Involvement of headless myosin X in the motility of immortalized gonadotropin-releasing hormone neuronal cellsQ37339182
Cytoskeletal dynamics in growth-cone steering.Q37610679
Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortexQ38799056
The spatial and temporal dynamics of pleckstrin homology domain binding at the plasma membrane measured by imaging single molecules in live mouse myoblastsQ39674089
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule levelQ41978648
Axon branching requires interactions between dynamic microtubules and actin filaments.Q43819985
Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex.Q46734175
Filopodia are required for cortical neurite initiation.Q46891046
The slice overlay assay: a versatile tool to study the influence of extracellular signals on neuronal developmentQ48582810
MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion.Q52118712
A microtubule-binding myosin required for nuclear anchoring and spindle assembly.Q52560093
PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation.Q52604153
Phospholipid-dependent regulation of the motor activity of myosin X.Q52612413
The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head.Q52857621
Isolation, culture, and differentiation of progenitor cells from the central nervous systemQ83487949
P4510describes a project that usesImageJQ1659584
P433issue30
P407language of work or nameEnglishQ1860
P304page(s)24873-24883
P577publication date2012-05-31
P1433published inJournal of Biological ChemistryQ867727
P1476titleHeadless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons
P478volume287

Reverse relations

cites work (P2860)
Q44507684Both Myosin-10 isoforms are required for radial neuronal migration in the developing cerebral cortex
Q45093732Cloning, characterization, and promoter analysis of mouse Myo10 gene
Q47136070IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth.
Q37226406Myosin X and its motorless isoform differentially modulate dendritic spine development by regulating trafficking and retention of vasodilator-stimulated phosphoprotein
Q89545561Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis
Q35964174Myosin X regulates neuronal radial migration through interacting with N-cadherin
Q37245779Myosin-10 independently influences mitotic spindle structure and mitotic progression
Q26825835Myosin-X and disease
Q47139973Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation.
Q61444640Phenotypic analysis of Myo10 knockout (Myo10) mice lacking full-length (motorized) but not brain-specific headless myosin X
Q37577398RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns
Q92932176The emerging role of minor intron splicing in neurological disorders
Q94465899Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease

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