Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia

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Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.1740-10.2010
P8608Fatcat IDrelease_doqh4k5ssbhtddsvg4q7pgepba
P932PMC publication ID2944214
P698PubMed publication ID20826681

P2093author name stringGianluca Gallo
Andrea Ketschek
P2860cites workThe small GTPase RalA targets filamin to induce filopodiaQ22008839
E3 ligase Nedd4 promotes axon branching by downregulating PTENQ24630190
The phosphoinositide 3-kinase pathwayQ27860738
Neurotrophin signal transduction in the nervous systemQ27876223
Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon GuidanceQ28209458
The exocyst complex binds the small GTPase RalA to mediate filopodia formationQ28211412
Pten regulates neuronal arborization and social interaction in miceQ28512488
Cordon-bleu is an actin nucleation factor and controls neuronal morphologyQ28565024
Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cellsQ28576273
NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APCQ28586090
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosisQ28594183
Regulation of actin filament assembly by Arp2/3 complex and forminsQ29615161
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapsesQ29615239
Mechanism of filopodia initiation by reorganization of a dendritic networkQ29616648
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblastsQ30437196
RhoA-kinase and myosin II are required for the maintenance of growth cone polarity and guidance by nerve growth factorQ30477696
Neurite consolidation is an active process requiring constant repression of protrusive activityQ30485868
Axon extension in the fast and slow lanes: substratum-dependent engagement of myosin II functionsQ30487289
Protein synthesis in distal axons is not required for growth cone responses to guidance cuesQ30491242
Filopodial initiation and a novel filament-organizing center, the focal ringQ30531077
Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigationQ30549635
Roles of neurotrophins on synaptic development and functions in the central nervous system.Q33543654
Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesisQ33595218
Integrin-mediated signal transduction pathwaysQ33698935
Enzymology and biology of CaaX protein prenylation.Q33766907
Common mechanisms underlying growth cone guidance and axon branchingQ33996741
Neurotrophins and the dynamic regulation of the neuronal cytoskeletonQ33996747
Pleckstrin homology domains and the cytoskeletonQ34120310
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.Q34576586
Biological aspects of signal transduction by cell adhesion receptorsQ34840579
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways.Q35189957
Axon Guidance by Growth Cones and Branches: Common Cytoskeletal and Signaling MechanismsQ35568663
Expression of phosphatidylinositol (4,5) bisphosphate-specific pleckstrin homology domains alters direction but not the level of axonal transport of mitochondria.Q35973416
Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signalingQ36096852
Role of fascin in filopodial protrusionQ36118593
Compartmentalized signalling of Ras.Q36206390
Induction of filopodia by direct local elevation of intracellular calcium ion concentrationQ36256515
Ral GTPases regulate neurite branching through GAP-43 and the exocyst complexQ36320505
Collateral sprouting as a target for improved function after spinal cord injuryQ36455780
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spinesQ36498526
Phosphoinositide 3-kinase signalling events controlling axonal morphogenesisQ36764073
Mitochondrial membrane potential in axons increases with local nerve growth factor or semaphorin signalingQ37003099
Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapyQ37212251
Phosphoinositide 3-kinases in cell migrationQ37340915
Filopodia: Complex models for simple rods.Q37477758
Review of the mechanism of processive actin filament elongation by forminsQ37491020
Dendritic spine formation and stabilizationQ37518210
Mitochondrial transport dynamics in axons and dendrites.Q37543095
Actin in axons: stable scaffolds and dynamic filamentsQ37543120
Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1.Q40508864
PIP3 is involved in neuronal polarization and axon formation.Q40523895
Beta1-integrin and PTEN control the phosphorylation of protein kinase C.Q40841368
Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinaseQ41607684
RhoA-kinase coordinates F-actin organization and myosin II activity during semaphorin-3A-induced axon retractionQ41850973
Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite functionQ42797507
Neuronal growth cone collapse triggers lateral extensions along trailing axonsQ42817277
Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6.Q42846604
Improved methods for using glass coverslips in cell culture and electron microscopyQ44085821
Actin-ATP hydrolysis is a major energy drain for neurons.Q44270163
Sensory neuron subtypes have unique substratum preference and receptor expression before target innervation.Q44357337
Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain.Q44452757
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.Q44831766
Dynamics of target recognition by interstitial axon branching along developing cortical axons.Q45979442
Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivoQ46119326
Effects of mitochondrial poisons on glutathione redox potential and carotid body chemoreceptor activity.Q46256468
Integrin activation and neurotrophin signaling cooperate to enhance neurite outgrowth in sensory neuronsQ46448625
PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth coneQ46620867
Semaphorin 3A inhibits ERM protein phosphorylation in growth cone filopodia through inactivation of PI3K.Q46712988
Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.Q46843629
PTEN couples Sema3A signalling to growth cone collapse.Q46958384
Calcium/calmodulin-dependent protein kinase II alters structural plasticity and cytoskeletal dynamics in Drosophila.Q47070343
Localized sources of neurotrophins initiate axon collateral sprouting.Q47892497
Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathwayQ48210209
Nerve growth factor signaling regulates motility and docking of axonal mitochondria.Q51642532
Inhibition of energy-transducing reactions by 8-nitreno-ATP covalently bound to bovine heart submitochondrial particles: direct interaction between ATPase and redox enzymes.Q52456066
A sensory role for neuronal growth cone filopodiaQ59067973
Electron transport systems of yeast. 3. Preparation and properties of cytochrome oxidaseQ68560426
The regulation of bidirectional mitochondrial transport is coordinated with axonal outgrowthQ72789184
The trkA receptor mediates growth cone turning toward a localized source of nerve growth factorQ73470143
Different contributions of microtubule dynamics and transport to the growth of axons and collateral sproutsQ77420042
Combined integrin activation and intracellular cAMP cause Rho GTPase dependent growth cone collapse on laminin-1Q80087247
Mitochondrial swelling impairs the transport of organelles in cerebellar granule neuronsQ81038733
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
P304page(s)12185-12197
P577publication date2010-09-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleNerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia
P478volume30

Reverse relations

cites work (P2860)
Q33585370A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling.
Q41465736Actin Aggregations Mark the Sites of Neurite Initiation
Q34533332Activation of PI3K and R-Ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycans
Q36719650Amitriptyline protects against TNF-α-induced atrophy and reduction in synaptic markers via a Trk-dependent mechanism
Q38153370Application of FRET probes in the analysis of neuronal plasticity
Q30834300Automated analysis of filopodial length and spatially resolved protein concentration via adaptive shape tracking
Q39032755Autophagy and epithelial-mesenchymal transition: an intricate interplay in cancer
Q42731527Axonal filopodial asymmetry induced by synaptic target
Q37011837Axonally synthesized β-actin and GAP-43 proteins support distinct modes of axonal growth
Q38817042Beyond the cytoskeleton: The emerging role of organelles and membrane remodeling in the regulation of axon collateral branches
Q40868920Bidirectional actin transport is influenced by microtubule and actin stability
Q27022646Branch management: mechanisms of axon branching in the developing vertebrate CNS
Q39203508Building branched tissue structures: from single cell guidance to coordinated construction.
Q39590290CSPGs inhibit axon branching by impairing mitochondria-dependent regulation of actin dynamics and axonal translation
Q34371722Cell biology in neuroscience: Cellular and molecular mechanisms underlying axon formation, growth, and branching
Q47774734Chondroitin sulfate proteoglycans negatively regulate the positioning of mitochondria and endoplasmic reticulum to distal axons
Q38235653Cytoskeletal and signaling mechanisms of neurite formation
Q41639990Drebrin coordinates the actin and microtubule cytoskeleton during the initiation of axon collateral branches
Q37958909From filopodia to synapses: the role of actin-capping and anti-capping proteins.
Q36127036Headless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons
Q35036402Highly efficient method for gene delivery into mouse dorsal root ganglia neurons
Q35173117Imaging adhesion and signaling dynamics in Xenopus laevis growth cones
Q30501550In vivo imaging of cell behaviors and F-actin reveals LIM-HD transcription factor regulation of peripheral versus central sensory axon development
Q38220858Involvement of Rho-family GTPases in axon branching
Q39209401It takes a village to raise a branch: Cellular mechanisms of the initiation of axon collateral branches
Q24321432Local F-actin network links synapse formation and axon branching
Q41521913Localized regulation of the axon shaft during the emergence of collateral branches
Q42713319Mechanism of NGF-induced formation of axonal filopodia: NGF turns up the volume, but the song remains the same?
Q42416458Mitochondria coordinate sites of axon branching through localized intra-axonal protein synthesis
Q38115765More than one ring to bind them all: recent insights into the structure of the axon
Q88647924NGF Attenuates High Glucose-Induced ER Stress, Preventing Schwann Cell Apoptosis by Activating the PI3K/Akt/GSK3β and ERK1/2 Pathways
Q35875769NGF in Early Embryogenesis, Differentiation, and Pathology in the Nervous and Immune Systems
Q33690281Nerve growth factor improves functional recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis in rats with spinal cord injury
Q30741119Nerve growth factor promotes reorganization of the axonal microtubule array at sites of axon collateral branching
Q41183697Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex
Q52138906Neuritin Mediates Activity-Dependent Axonal Branch Formation in Part via FGF Signaling.
Q37387436Neurotrophin selectivity in organizing topographic regeneration of nociceptive afferents
Q83226423Neurotrophins induce fission of mitochondria along embryonic sensory axons
Q47548720Nuclear Excluded Autism-Associated Phosphatase and Tensin Homolog Mutations Dysregulate Neuronal Growth.
Q27310062Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis
Q37155345PIP₃ regulates spinule formation in dendritic spines during structural long-term potentiation
Q40076084Proprotein convertase furin enhances survival and migration of vascular smooth muscle cells via processing of pro-nerve growth factor
Q28587622Pten knockdown in vivo increases excitatory drive onto dentate granule cells
Q43211145RNA-binding protein Vg1RBP regulates terminal arbor formation but not long-range axon navigation in the developing visual system
Q34408301Reciprocal regulation of axonal Filopodia and outgrowth during neuromuscular junction development
Q27346784Regulation of ECM degradation and axon guidance by growth cone invadosomes.
Q40243543Schwann Cell Expressed Nogo-B Modulates Axonal Branching of Adult Sensory Neurons Through the Nogo-B Receptor NgBR.
Q36279816Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics
Q35763049Short Lives with Long-Lasting Effects: Filopodia Protrusions in Neuronal Branching Morphogenesis
Q27674679Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor
Q38154640Structure meets function: actin filaments and myosin motors in the axon
Q27022790Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders
Q47759271Synaptotagmin-1 promotes the formation of axonal filopodia and branches along the developing axons of forebrain neurons
Q36792598The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity.
Q98200029The Bioenergetics of Neuronal Morphogenesis and Regeneration: Frontiers Beyond the Mitochondrion
Q30503395The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia
Q28305090The cytoskeletal and signaling mechanisms of axon collateral branching
Q40801033The dynein inhibitor Ciliobrevin D inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches
Q30539638The formins FMNL1 and mDia1 regulate coiling phagocytosis of Borrelia burgdorferi by primary human macrophages
Q42413096The initiation of post-synaptic protrusions
Q46285997The role of mitochondria in axon development and regeneration.
Q38220785The role of phosphoinositides in synapse function
Q38954442Tyrosine 251 at the C-terminus of neuronal glycoprotein M6a is critical for neurite outgrowth

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