Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.3799-09.2009
P932PMC publication ID2807632
P698PubMed publication ID19890007
P5875ResearchGate publication ID38067708

P50authorHuaibin CaiQ48206451
Evy LobbestaelQ57982085
Veerle BaekelandtQ30112409
Jean-Marc TaymansQ30112411
P2093author name stringXian Lin
Chengsong Xie
Cai-Xia Long
Hyun Jin Cho
Lixin Sun
Loukia Parisiadou
Xing-Long Gu
P2860cites workPersistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer diseaseQ21144713
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activityQ22254785
High Ca2+-phosphate transfection efficiency in low-density neuronal culturesQ48218879
Rho kinase activates ezrin-radixin-moesin (ERM) proteins and mediates their function in cortical neuron growth, morphology and motility in vitroQ48382402
Ballistic labeling and dynamic imaging of astrocytes in organotypic hippocampal slice culturesQ50784326
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.Q54781213
Kinase activity of mutant LRRK2 mediates neuronal toxicityQ24303603
The familial Parkinsonism gene LRRK2 regulates neurite process morphologyQ24317613
Localization of LRRK2 to membranous and vesicular structures in mammalian brainQ24318643
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathwayQ24671083
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathologyQ28131833
LRRK2 in Parkinson's disease: protein domains and functional insightsQ28235024
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's diseaseQ28292932
Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stressQ28511013
Efficient in vivo manipulation of mouse genomic sequences at the zygote stageQ29547306
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activityQ29615144
Control of memory formation through regulated expression of a CaMKII transgeneQ29619261
ERM proteins and merlin: integrators at the cell cortexQ29619893
Kinase activity is required for the toxic effects of mutant LRRK2/dardarinQ29620478
Radixin is involved in lamellipodial stability during nerve growth cone motilityQ30629181
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.Q33292556
ERM proteins in cell adhesion and membrane dynamicsQ33632981
Changes in membrane trafficking and actin dynamics during axon formation in cultured hippocampal neuronsQ33808584
The role of local actin instability in axon formationQ33855372
Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocationQ34319783
Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease geneticsQ34546733
The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestorQ35447263
Merlin and the ERM proteins in Schwann cells, neurons and growth conesQ35777641
Changes in microtubule polarity orientation during the development of hippocampal neurons in cultureQ36222341
Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neuronsQ36255600
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletonsQ36382880
Mutations in LRRK2 as a cause of Parkinson's diseaseQ37039473
Actin remodeling requires ERM function to facilitate AQP2 apical targeting.Q40392860
Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytesQ41063804
The organization of myosin and actin in rapid frozen nerve growth conesQ41564848
Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein familyQ42720142
Serine phosphorylation negatively regulates RhoA in vivo.Q42803864
Filamentous actin is concentrated in specific subpopulations of neuronal and glial structures in rat central nervous systemQ43823173
cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI.Q44364081
P4510describes a project that usesImageJQ1659584
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
phosphorylationQ242736
morphogenesisQ815547
P304page(s)13971-13980
P577publication date2009-11-01
P1433published inJournal of NeuroscienceQ1709864
P1476titlePhosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis
P478volume29

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