scholarly article | Q13442814 |
P50 | author | Huaibin Cai | Q48206451 |
Evy Lobbestael | Q57982085 | ||
Veerle Baekelandt | Q30112409 | ||
Jean-Marc Taymans | Q30112411 | ||
P2093 | author name string | Xian Lin | |
Chengsong Xie | |||
Cai-Xia Long | |||
Hyun Jin Cho | |||
Lixin Sun | |||
Loukia Parisiadou | |||
Xing-Long Gu | |||
P2860 | cites work | Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease | Q21144713 |
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity | Q22254785 | ||
High Ca2+-phosphate transfection efficiency in low-density neuronal cultures | Q48218879 | ||
Rho kinase activates ezrin-radixin-moesin (ERM) proteins and mediates their function in cortical neuron growth, morphology and motility in vitro | Q48382402 | ||
Ballistic labeling and dynamic imaging of astrocytes in organotypic hippocampal slice cultures | Q50784326 | ||
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays. | Q54781213 | ||
Kinase activity of mutant LRRK2 mediates neuronal toxicity | Q24303603 | ||
The familial Parkinsonism gene LRRK2 regulates neurite process morphology | Q24317613 | ||
Localization of LRRK2 to membranous and vesicular structures in mammalian brain | Q24318643 | ||
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway | Q24671083 | ||
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology | Q28131833 | ||
LRRK2 in Parkinson's disease: protein domains and functional insights | Q28235024 | ||
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease | Q28292932 | ||
Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress | Q28511013 | ||
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage | Q29547306 | ||
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity | Q29615144 | ||
Control of memory formation through regulated expression of a CaMKII transgene | Q29619261 | ||
ERM proteins and merlin: integrators at the cell cortex | Q29619893 | ||
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin | Q29620478 | ||
Radixin is involved in lamellipodial stability during nerve growth cone motility | Q30629181 | ||
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. | Q33292556 | ||
ERM proteins in cell adhesion and membrane dynamics | Q33632981 | ||
Changes in membrane trafficking and actin dynamics during axon formation in cultured hippocampal neurons | Q33808584 | ||
The role of local actin instability in axon formation | Q33855372 | ||
Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation | Q34319783 | ||
Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics | Q34546733 | ||
The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor | Q35447263 | ||
Merlin and the ERM proteins in Schwann cells, neurons and growth cones | Q35777641 | ||
Changes in microtubule polarity orientation during the development of hippocampal neurons in culture | Q36222341 | ||
Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons | Q36255600 | ||
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons | Q36382880 | ||
Mutations in LRRK2 as a cause of Parkinson's disease | Q37039473 | ||
Actin remodeling requires ERM function to facilitate AQP2 apical targeting. | Q40392860 | ||
Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes | Q41063804 | ||
The organization of myosin and actin in rapid frozen nerve growth cones | Q41564848 | ||
Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family | Q42720142 | ||
Serine phosphorylation negatively regulates RhoA in vivo. | Q42803864 | ||
Filamentous actin is concentrated in specific subpopulations of neuronal and glial structures in rat central nervous system | Q43823173 | ||
cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI. | Q44364081 | ||
P4510 | describes a project that uses | ImageJ | Q1659584 |
P433 | issue | 44 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cytoskeleton | Q154626 |
phosphorylation | Q242736 | ||
morphogenesis | Q815547 | ||
P304 | page(s) | 13971-13980 | |
P577 | publication date | 2009-11-01 | |
P1433 | published in | Journal of Neuroscience | Q1709864 |
P1476 | title | Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis | |
P478 | volume | 29 |
Q36402571 | 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. |
Q99711175 | A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2 |
Q24296968 | A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity |
Q35176338 | A comparative study of Lrrk2 function in primary neuronal cultures |
Q24310126 | A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation |
Q48129676 | AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression. |
Q41279255 | Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes |
Q24317631 | Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice |
Q37080018 | Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation |
Q41916939 | An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease. |
Q24315778 | An early endosome regulator, Rab5b, is an LRRK2 kinase substrate |
Q39117185 | An exome study of Parkinson's disease in Sardinia, a Mediterranean genetic isolate |
Q89013363 | An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis |
Q55000928 | Astrocytes, Microglia, and Parkinson's Disease. |
Q35172817 | Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities |
Q35923102 | Axon degeneration in Parkinson's disease |
Q35774155 | Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. |
Q37590635 | Back to the tubule: microtubule dynamics in Parkinson's disease |
Q38044430 | Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins |
Q38433725 | Cellular processes associated with LRRK2 function and dysfunction |
Q42805112 | Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2. |
Q34052764 | Clinical progression in Parkinson disease and the neurobiology of axons. |
Q30653185 | Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration |
Q35545939 | Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5. |
Q26827527 | Current Understanding Of LRRK2 In Parkinson’s Disease: Biochemical And Structural Features And Inhibitor Design |
Q35422898 | Cytoskeletal Alterations and Biomechanical Properties of parkin-Mutant Human Primary Fibroblasts. |
Q39332471 | DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study |
Q33611632 | Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors |
Q41812724 | Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation |
Q37249125 | Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease. |
Q24299578 | Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways |
Q44796586 | Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome |
Q39139476 | Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2 |
Q50038138 | Distinctive roles of Rac1 and Rab29 in LRRK2 mediatedmembrane trafficking and neurite outgrowth |
Q21135493 | Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. |
Q41117800 | Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects |
Q50135395 | Drosophila hep pathway mediates Lrrk2-induced neurodegeneration. |
Q24324231 | Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans |
Q33593798 | ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease |
Q33945342 | Efficient Allele-Specific Targeting of LRRK2 R1441 Mutations Mediated by RNAi |
Q50985376 | Excessive Expression of Hippocampal Ezrin Is Induced by Intrastriatal Injection of 6-Hydroxydopamine |
Q42829531 | Ezrin mediates neuritogenesis via down-regulation of RhoA activity in cultured cortical neurons |
Q24314894 | Ezrin/Exocyst complex regulates mucin 5AC secretion induced by neutrophil elastase in human airway epithelial cells |
Q24310218 | Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily |
Q21144926 | GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1 |
Q24306167 | GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2 |
Q35148581 | Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications |
Q64866880 | Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease |
Q39289038 | Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease. |
Q37583402 | Genetic insights into sporadic Parkinson's disease pathogenesis |
Q28077356 | Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance |
Q27013695 | Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications |
Q27303568 | High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain |
Q28475942 | Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif |
Q30596172 | Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations |
Q38044434 | Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models |
Q38234885 | Interaction of LRRK2 with kinase and GTPase signaling cascades |
Q34936423 | Intracellular signalling pathways in dopamine cell death and axonal degeneration. |
Q42737973 | Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities |
Q35498549 | Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant |
Q27322966 | LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase |
Q42873469 | LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß. |
Q37368913 | LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2 |
Q38620229 | LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand? |
Q35688632 | LRRK2 Parkinson disease mutations enhance its microtubule association. |
Q37890433 | LRRK2 Parkinson's disease: from animal models to cellular mechanisms |
Q40899192 | LRRK2 Promotes Tau Accumulation, Aggregation and Release. |
Q35027709 | LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization |
Q42005064 | LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts. |
Q92426993 | LRRK2 and membrane trafficking: nexus of Parkinson's disease |
Q54976406 | LRRK2 and mitochondria: Recent advances and current views. |
Q38198207 | LRRK2 and neuroinflammation: partners in crime in Parkinson's disease? |
Q38044441 | LRRK2 and vesicle trafficking |
Q38689010 | LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease. |
Q64074429 | LRRK2 deficiency induced mitochondrial Ca efflux inhibition can be rescued by Na/Ca/Li exchanger upregulation |
Q34280111 | LRRK2 function on actin and microtubule dynamics in Parkinson disease |
Q36493605 | LRRK2 inhibition attenuates microglial inflammatory responses |
Q30524899 | LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors |
Q39732847 | LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways |
Q38253871 | LRRK2 pathobiology in Parkinson's disease |
Q24304347 | LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth |
Q24323196 | LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity |
Q38218398 | LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis |
Q37635000 | LRRK2: Cause, Risk, and Mechanism |
Q36888947 | LRRK2: an éminence grise of Wnt-mediated neurogenesis? |
Q35661537 | Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response |
Q37955275 | Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions |
Q37829776 | Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease? |
Q41791628 | Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation |
Q34259058 | Leucine-rich repeat kinase 2 for beginners: six key questions. |
Q28267434 | Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain |
Q28743800 | Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells |
Q24303851 | Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export |
Q33636286 | Leucine-rich repeat kinase 2-linked Parkinson's disease: clinical and molecular findings |
Q34005501 | Lrrk2 localization in the primate basal ganglia and thalamus: a light and electron microscopic analysis in monkeys |
Q38038561 | Lysosome-dependent pathways as a unifying theme in Parkinson's disease. |
Q36325784 | Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau. |
Q37996364 | Mechanisms of LRRK2-Mediated Neurodegeneration |
Q33920691 | Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy |
Q36525872 | MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein. |
Q38843644 | MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments? |
Q34170717 | Mitochondria and Neuroplasticity |
Q47643867 | Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants |
Q37625339 | Mitochondrial Dynamics in Retinal Ganglion Cell Axon Regeneration and Growth Cone Guidance |
Q35412397 | Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First? |
Q35799128 | Mitochondrial Quality Control and Dynamics in Parkinson's Disease |
Q38021865 | Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences |
Q35799109 | Mitochondrial dysfunction in genetic animal models of Parkinson's disease |
Q58726898 | Modeling Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells |
Q34986076 | Models for LRRK2-Linked Parkinsonism |
Q26781619 | Morphological changes of glutamatergic synapses in animal models of Parkinson's disease |
Q26752246 | Mouse Genetic Models of Human Brain Disorders |
Q24628425 | Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons |
Q34086842 | Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration |
Q24323228 | Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death |
Q30496687 | Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia |
Q38268886 | Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression |
Q36379938 | Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. |
Q38071833 | Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease |
Q27312569 | No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts |
Q34637362 | Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo |
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Q48192270 | Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation |
Q89947277 | Parkinson's disease-associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages |
Q89786852 | Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging |
Q35940803 | Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity |
Q53387936 | Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression |
Q99716681 | Pathogenic LRRK2 requires secondary factors to induce cellular toxicity |
Q37595673 | Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling |
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Q28586694 | Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease |
Q38182492 | Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2). |
Q29347547 | Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity. |
Q92716998 | RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits |
Q37325908 | RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis |
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Q42970335 | Radixin inhibition decreases adult neural progenitor cell migration and proliferation in vitro and in vivo. |
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Q64870243 | Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease |
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Q41978493 | Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice. |
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