| scholarly article | Q13442814 |
| P50 | author | Ralf Kühn | Q50556941 |
| Florian Giesert | Q58210496 | ||
| W. Wurst | Q67390467 | ||
| Daniela M Vogt Weisenhorn | Q99247915 | ||
| P2093 | author name string | Thomas Ott | |
| Thomas Gasser | |||
| Marita Munz | |||
| Saskia Biskup | |||
| Kathrin Brockmann | |||
| Natalja Funk | |||
| Andrea Wenninger-Weinzierl | |||
| P2860 | cites work | Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10 | Q24291135 |
| Insulin signalling and the regulation of glucose and lipid metabolism | Q24292020 | ||
| A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain | Q24296738 | ||
| Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2) | Q24298459 | ||
| LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis | Q24299176 | ||
| Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export | Q24303851 | ||
| LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations | Q24306239 | ||
| LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism | Q24309509 | ||
| Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3 | Q24314472 | ||
| An early endosome regulator, Rab5b, is an LRRK2 kinase substrate | Q24315778 | ||
| The familial Parkinsonism gene LRRK2 regulates neurite process morphology | Q24317613 | ||
| LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25 | Q24317760 | ||
| The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease | Q24339515 | ||
| AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain | Q24536241 | ||
| Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells | Q24651391 | ||
| The role of the LRRK2 gene in Parkinsonism | Q27023749 | ||
| Rab proteins as membrane organizers | Q27860861 | ||
| Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases | Q28119192 | ||
| Rab GTPases as coordinators of vesicle traffic | Q28131746 | ||
| Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology | Q28131833 | ||
| Regulated transport of the glucose transporter GLUT4 | Q28216848 | ||
| PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes | Q28218162 | ||
| Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain | Q28267434 | ||
| The role of insulin receptor signaling in synaptic plasticity and cognitive function | Q28281182 | ||
| Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease | Q28292932 | ||
| Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus | Q28297517 | ||
| Urtica dioica extract attenuates depressive like behavior and associative memory dysfunction in dexamethasone induced diabetic mice | Q28305994 | ||
| The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse. | Q50435787 | ||
| Structural interface between LRRK2 and 14-3-3 protein. | Q51002850 | ||
| Type 2 diabetes and the risk of Parkinson's disease. | Q53016612 | ||
| Human fibroblasts express the insulin-responsive glucose transporter (GLUT4) | Q68395374 | ||
| LRRK2 and Parkinson´s disease: from lack of structure to gain of function | Q38769355 | ||
| Bcl-xL-mediated antioxidant function abrogates the disruption of mitochondrial dynamics induced by LRRK2 inhibition. | Q38830372 | ||
| An updated review of Parkinson's disease genetics and clinicopathological correlations. | Q38856753 | ||
| LRRK2 and Autophagy | Q38869514 | ||
| Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking | Q38888703 | ||
| Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action | Q39364864 | ||
| 14-3-3 proteins are promising LRRK2 interactors | Q39663092 | ||
| The relationship between diabetes mellitus and Parkinson's disease | Q40701172 | ||
| Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice. | Q41978493 | ||
| LRRK2 secretion in exosomes is regulated by 14-3-3. | Q42149865 | ||
| Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers | Q42466909 | ||
| Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein | Q42485048 | ||
| A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160. | Q42798386 | ||
| Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. | Q42829358 | ||
| Akt signal transduction dysfunction in Parkinson's disease | Q43267759 | ||
| A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane | Q44206934 | ||
| GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells | Q46466470 | ||
| Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila | Q47733442 | ||
| Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation | Q48192270 | ||
| Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice | Q48238735 | ||
| 100 years of Lewy pathology | Q48278741 | ||
| LRRK2 interferes with aggresome formation for autophagic clearance | Q48647645 | ||
| Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice | Q28507051 | ||
| Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane | Q28507956 | ||
| Insulin signalling | Q28611467 | ||
| mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1 | Q28822211 | ||
| Epidemiology of Parkinson's disease | Q29614901 | ||
| Epidemiology, environmental risk factors and genetics of Parkinson's disease. | Q30238483 | ||
| Genetics of Parkinson's disease. | Q30241723 | ||
| A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology | Q30887351 | ||
| Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis | Q33595218 | ||
| Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). | Q33757616 | ||
| Role of LRRK2 in the regulation of dopamine receptor trafficking | Q33764887 | ||
| The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions. | Q33905778 | ||
| Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution | Q33985278 | ||
| Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation | Q34183649 | ||
| Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking | Q34449983 | ||
| Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic | Q34778453 | ||
| Diabetes and the risk of developing Parkinson's disease in Denmark. | Q35043736 | ||
| A comparative study of Lrrk2 function in primary neuronal cultures | Q35176338 | ||
| Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5. | Q35545939 | ||
| GLUT4 exocytosis. | Q35672106 | ||
| Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. | Q35766417 | ||
| Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications. | Q35898211 | ||
| Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures | Q36037105 | ||
| The role of LRRK2 in inflammatory bowel disease | Q36079983 | ||
| 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. | Q36402571 | ||
| The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes | Q36435173 | ||
| LRRK2 inhibition attenuates microglial inflammatory responses | Q36493605 | ||
| LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation | Q37583930 | ||
| Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake. | Q37588533 | ||
| Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons | Q37660899 | ||
| Rab GTPases: The Key Players in the Molecular Pathway of Parkinson's Disease | Q37724701 | ||
| Regulation of glucose transporter translocation in health and diabetes | Q38000677 | ||
| Regulation of glucose transport by insulin: traffic control of GLUT4. | Q38012259 | ||
| Does Parkinson's disease and type-2 diabetes mellitus present common pathophysiological mechanisms and treatments? | Q38140969 | ||
| Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. | Q38311520 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Parkinson's disease | Q11085 |
| P304 | page(s) | 4515 | |
| P577 | publication date | 2019-03-14 | |
| P1433 | published in | Scientific Reports | Q2261792 |
| P1476 | title | The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4 | |
| P478 | volume | 9 |
| Q97692894 | Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing | cites work | P2860 |
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