Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

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Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.AJPATH.2012.10.027
P3181OpenCitations bibliographic resource ID1420102
P932PMC publication ID3562730
P698PubMed publication ID23231918
P5875ResearchGate publication ID233900436

P50authorCharleen T. ChuQ42324219
P2093author name stringSalvatore J Cherra
Kirill Kiselyov
Aaron M Gusdon
Erin Steer
P2860cites workDopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.Q21135493
Guidelines for the use and interpretation of assays for monitoring autophagyQ21996341
Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons.Q42504276
Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.Q42790455
Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).Q43141823
Morphology, electrophysiology and functional input connectivity of pyramidal neurons characterizes a genuine layer va in the primary somatosensory cortexQ46472848
Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons.Q46900848
Spontaneous synchronous synaptic calcium transients in cultured cortical neuronsQ48402191
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal levelQ48858572
Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells.Q52073489
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.Q54781213
Pretreatment with nimodipine prevents MPTP-induced neurotoxicity at the nigral, but not at the striatal level in miceQ71860224
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activityQ22254785
LRRK2 controls synaptic vesicle storage and mobilization within the recycling poolQ24292798
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repressionQ24293587
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADPQ24293723
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Q24297155
Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)Q24298459
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutationsQ24306239
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
The familial Parkinsonism gene LRRK2 regulates neurite process morphologyQ24317613
Localization of LRRK2 to membranous and vesicular structures in mammalian brainQ24318643
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fissionQ24320327
The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitroQ24322792
LRRK2 regulates synaptic vesicle endocytosisQ24336523
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's diseaseQ24336655
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicityQ24338647
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localizationQ24339094
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Regulation of the autophagy protein LC3 by phosphorylationQ24627351
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cellsQ24651391
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular modelQ24656256
ATP13A2 regulates mitochondrial bioenergetics through macroautophagyQ28116275
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathologyQ28131833
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
'Rejuvenation' protects neurons in mouse models of Parkinson's diseaseQ28305585
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1Q28510145
Pruning and loss of excitatory synapses by the parkin ubiquitin ligaseQ28576054
Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's diseaseQ28586694
Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019SQ28589899
Autophagy as a regulated pathway of cellular degradationQ29547914
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagyQ29614178
Chronic systemic pesticide exposure reproduces features of Parkinson's diseaseQ29614763
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activityQ29615144
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapsesQ29615239
The PINK1/Parkin pathway regulates mitochondrial morphologyQ29615641
Kinase activity is required for the toxic effects of mutant LRRK2/dardarinQ29620478
Localization and targeting of voltage-dependent ion channels in mammalian central neurons.Q30492681
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseasesQ31030866
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegansQ33225632
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylationQ33525587
Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesisQ33595218
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's diseaseQ33754793
Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptorsQ33953018
LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's diseaseQ34079774
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.Q34165508
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagyQ34399382
Genetics of Parkinson's disease: LRRK2 on the riseQ34470633
Mitophagy selectively degrades individual damaged mitochondria after photoirradiationQ34806021
Diversity in the regulation of autophagy and mitophagy: lessons from Parkinson's disease.Q34985943
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegansQ35080550
The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's diseaseQ35607214
Mitochondria: the next (neurode)generationQ36124905
Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitationQ36484737
Calcium and neurodegenerationQ36747495
Imaging of mitochondrial polarization and depolarization with cationic fluorophoresQ36796225
Visualization and quantification of mitochondrial dynamics in living animal cells.Q36796290
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in DrosophilaQ36891456
Autophagy in neuroprotection and neurodegeneration: A question of balance.Q36893822
Progress in Parkinson's disease-where do we stand?Q37200943
Mitochondria in neuroplasticity and neurological disordersQ37216404
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.Q37408628
Mitochondrial calcium function and dysfunction in the central nervous systemQ37418288
Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?Q39834913
Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagyQ41861209
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
P304page(s)474-484
P577publication date2012-12-08
P1433published inThe American Journal of PathologyQ4744259
P1476titleMutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons
P478volume182

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cites work (P2860)
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