Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor

scientific article

Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E11-04-0354
P3181OpenCitations bibliographic resource ID3862942
P932PMC publication ID3216653
P698PubMed publication ID21965296

P50authorMingjie ZhangQ52571130
Zhiyi WeiQ55117833
Qing LuQ58888963
P2093author name stringJing Yan
Jiang Yu
P2860cites workMyosin-X is a molecular motor that functions in filopodia formationQ24299253
Structural basis of cargo recognition by the myosin-X MyTH4-FERM domainQ24305586
Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeastQ24533315
Crystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domainsQ27626998
Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPaseQ27650175
Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domainQ27666969
Coot: model-building tools for molecular graphicsQ27860505
REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its useQ27860632
Main-chain bond lengths and bond angles in protein structuresQ27860635
Phasercrystallographic softwareQ27860930
Phosphoinositides in cell regulation and membrane dynamicsQ27861051
The CCP4 suite: programs for protein crystallographyQ27861090
Myosin X is a downstream effector of PI(3)K during phagocytosisQ28114999
Filopodia: molecular architecture and cellular functionsQ28279460
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranesQ28307257
Myosin X regulates netrin receptors and functions in axonal path-findingQ28506167
Membrane recognition by phospholipid-binding domainsQ29614848
The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.Q30480576
A myosin motor that selects bundled actin for motilityQ30482736
Myosin-X induces filopodia by multiple elongation mechanismQ30494868
Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodiaQ30496687
Myosin-X is required for cranial neural crest cell migration in Xenopus laevisQ30497957
Myosin-X is critical for migratory ability of Xenopus cranial neural crest cells.Q30576361
Structural characterization of the split pleckstrin homology domain in phospholipase C-gamma1 and its interaction with TRPC3.Q31032985
Myosin X transports Mena/VASP to the tip of filopodia.Q31065358
Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of rho kinasesQ31163835
Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.Q33917620
Myosin-X is an unconventional myosin that undergoes intrafilopodial motility.Q34115035
Myosin-X provides a motor-based link between integrins and the cytoskeleton.Q34322246
Structure of the split PH domain and distinct lipid-binding properties of the PH-PDZ supramodule of alpha-syntrophinQ34324850
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domainQ34576035
Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domainQ35641775
Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signalingQ36096852
Myosin-X: a molecular motor at the cell's fingertipsQ36248392
Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptorsQ36639095
Filopodia: the fingers that do the walkingQ36915801
The regulation of cell motility and chemotaxis by phospholipid signalingQ37089555
Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cellsQ40241493
DomIns: a web resource for domain insertions in known protein structuresQ40403229
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule levelQ41978648
A polybasic motif allows N-WASP to act as a sensor of PIP(2) densityQ45233508
PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation.Q52604153
Phospholipid-dependent regulation of the motor activity of myosin X.Q52612413
Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domainQ79290414
P433issue22
P921main subjectcell biologyQ7141
P304page(s)4268-78
P577publication date2011-11-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleStructural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor
P478volume22

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cites work (P2860)
Q30826156A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip
Q27306218Actin structure-dependent stepping of myosin 5a and 10 during processive movement
Q27673659Antiparallel coiled-coil-mediated dimerization of myosin X
Q45093732Cloning, characterization, and promoter analysis of mouse Myo10 gene
Q26823124Exploring the role of lipids in intercellular conduits: breakthroughs in the pipeline
Q35831801Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2.
Q37226406Myosin X and its motorless isoform differentially modulate dendritic spine development by regulating trafficking and retention of vasodilator-stimulated phosphoprotein
Q26825835Myosin-X and disease
Q30581595Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread
Q30513859Myosin-X functions in polarized epithelial cells
Q47139973Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation.
Q35576442Myosin-X: a MyTH-FERM myosin at the tips of filopodia
Q27004163Myosins in cell junctions
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Q28542983Novel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cells
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Q38021241Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms
Q89580715Redefining PTB domain into independently functional dual cores
Q38945036Simultaneous in situ quantification of two cellular lipid pools using orthogonal fluorescent sensors
Q38722191Structural Basis of Cargo Recognition by Unconventional Myosins in Cellular Trafficking
Q57164416Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling
Q92156441Unconventional Myosins: How Regulation Meets Function