scholarly article | Q13442814 |
P50 | author | Mark A. Lemmon | Q24076870 |
P2093 | author name string | Li Z | |
Skolnik EY | |||
Aronheim A | |||
Isakoff SJ | |||
Abagyan R | |||
Cardozo T | |||
Ferguson KM | |||
Andreev J | |||
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A Grb2-associated docking protein in EGF- and insulin-receptor signalling | Q24321653 | ||
Association of SET domain and myotubularin-related proteins modulates growth control | Q24323057 | ||
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase | Q24336639 | ||
Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia | Q24532248 | ||
Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes | Q24558736 | ||
Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta | Q24613360 | ||
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85 | Q24629213 | ||
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions | Q24646252 | ||
Structure of the binding site for inositol phosphates in a PH domain | Q27729737 | ||
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain | Q27732194 | ||
The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1) | Q27740320 | ||
Mammalian Ras interacts directly with the serine/threonine kinase Raf | Q27860833 | ||
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase | Q28115936 | ||
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B | Q28116107 | ||
Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit | Q28211409 | ||
Signalling through the lipid products of phosphoinositide-3-OH kinase | Q28241516 | ||
PH domain: the first anniversary | Q28242218 | ||
The PH domain: a common piece in the structural patchwork of signalling proteins | Q28256159 | ||
The function of GRB2 in linking the insulin receptor to Ras signaling pathways | Q28259867 | ||
Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase | Q28268264 | ||
A putative modular domain present in diverse signaling proteins | Q28269473 | ||
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis | Q28295920 | ||
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate | Q28301966 | ||
The activation of phosphatidylinositol 3-kinase by Ras | Q28305326 | ||
The role of the PH domain in the signal-dependent membrane targeting of Sos. | Q28569671 | ||
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains | Q28591070 | ||
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation | Q28616026 | ||
Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate | Q28616287 | ||
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav | Q28646540 | ||
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101 | Q28678835 | ||
Regulation of neuronal survival by the serine-threonine protein kinase Akt | Q29614185 | ||
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase | Q29618387 | ||
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction | Q29618388 | ||
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase | Q29620178 | ||
Synergistic activation of dynamin GTPase by Grb2 and phosphoinositides | Q30176283 | ||
DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. | Q30176932 | ||
BTKbase, mutation database for X-linked agammaglobulinemia (XLA). | Q30192775 | ||
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. | Q30194078 | ||
A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo | Q30194817 | ||
cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor | Q30195693 | ||
Homology modeling by the ICM method | Q30424405 | ||
A functional screen in yeast for regulators and antagonizers of heterologous protein tyrosine kinases | Q32060776 | ||
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain | Q33777007 | ||
Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase | Q33856733 | ||
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains | Q34436541 | ||
Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting. | Q34447681 | ||
The PROSITE database, its status in 1997. | Q34622236 | ||
Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain | Q34981771 | ||
Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase | Q36590074 | ||
Improved efficiency sos recruitment system: expression of the mammalian GAP reduces isolation of Ras GTPase false positives. | Q36873974 | ||
Phosphoinositide kinases | Q37902478 | ||
Structure-function relationships of the mouse Gap1m. Determination of the inositol 1,3,4,5-tetrakisphosphate-binding domain. | Q38354357 | ||
Phosphoinositide 3-kinases: a conserved family of signal transducers | Q38556727 | ||
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. | Q39481540 | ||
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. | Q40020748 | ||
Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway. | Q40023501 | ||
Structural Characterization of the Interaction between a Pleckstrin Homology Domain and Phosphatidylinositol 4,5-Bisphosphate | Q40458847 | ||
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? | Q40859203 | ||
The pleckstrin homology domain: an intriguing multifunctional protein module | Q40964864 | ||
Phosphoinositides as regulators in membrane traffic | Q40968891 | ||
PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface | Q40996433 | ||
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals | Q41037034 | ||
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. | Q41063499 | ||
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. | Q41067534 | ||
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase | Q41078571 | ||
Phosphoinositide kinases | Q41099687 | ||
Inositol phosphates - whither bound? Intracellular signalling. | Q41110658 | ||
X-linked agammaglobulinemia (XLA): a genetic tyrosine kinase (Btk) disease | Q41182308 | ||
PI3K: downstream AKTion blocks apoptosis | Q41351876 | ||
The function of inositol high polyphosphate binding proteins | Q41538624 | ||
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice | Q41541610 | ||
Unconventional myosins in cell movement, membrane traffic, and signal transduction | Q41687083 | ||
Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate | Q42061339 | ||
Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivo | Q42816311 | ||
Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling | Q46765571 | ||
Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains | Q47895700 | ||
Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain | Q48047170 | ||
Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity | Q54246428 | ||
Lipid-Regulated Kinases: Some Common Themes at Last | Q57903715 | ||
High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity | Q57986498 | ||
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins | Q70787161 | ||
Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity | Q71825216 | ||
High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate | Q71985042 | ||
Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid | Q72223349 | ||
Mammalian phosphatidylinositol 3'-kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product | Q72252456 | ||
Do aligned sequences share the same fold? | Q73876636 | ||
P433 | issue | 18 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 5374-5387 | |
P577 | publication date | 1998-09-01 | |
P1433 | published in | The EMBO Journal | Q1278554 |
P1476 | title | Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast | |
P478 | volume | 17 |
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Q33929512 | A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. |
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Q52560093 | A microtubule-binding myosin required for nuclear anchoring and spindle assembly. |
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Q28609913 | A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling |
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Q34751632 | A screen for novel phosphoinositide 3-kinase effector proteins. |
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Q36323151 | An anillin homologue, Mid2p, acts during fission yeast cytokinesis to organize the septin ring and promote cell separation |
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Q35057175 | Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site |
Q33762014 | Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions |
Q42093938 | Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging |
Q37970875 | Conditional peripheral membrane proteins: facing up to limited specificity |
Q34583779 | Cooperation of DEF6 with activated Rac in regulating cell morphology |
Q28513246 | Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses |
Q27619068 | Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1 |
Q38495083 | DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation |
Q22010461 | DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides |
Q37359982 | Deciphering soluble and membrane protein function using yeast systems (Review). |
Q38313340 | Determination of structural requirements and probable regulatory effectors for membrane association of maize sucrose synthase 1. |
Q30514794 | Differential regulation of myosin X movements by its cargos, DCC and neogenin. |
Q41262163 | Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP. |
Q33899291 | Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis |
Q34980011 | Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis |
Q33963349 | Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44. |
Q30164628 | Evolution of Gab family adaptor proteins |
Q27933752 | Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane |
Q28377996 | Expression cloning of protein targets for 3-phosphorylated phosphoinositides |
Q34012464 | Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression |
Q33652657 | FYVE finger proteins as effectors of phosphatidylinositol 3-phosphate |
Q21245511 | Function, regulation and pathological roles of the Gab/DOS docking proteins |
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Q30160040 | GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells |
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Q35176340 | Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma. |
Q42801574 | Gab1 signaling is regulated by EGF receptor sorting in early endosomes |
Q27934605 | Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains |
Q35053346 | Genome-wide analysis of signaling domain function |
Q24635831 | Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish |
Q27639493 | High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate |
Q34158953 | How do inhibitory phosphatases work? |
Q24292198 | Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices |
Q24554522 | Identification of a new Pyk2 target protein with Arf-GAP activity |
Q30168876 | Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases |
Q24297662 | Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle |
Q24290290 | Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities |
Q47070546 | In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling |
Q33292129 | Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins |
Q30159493 | Intramolecular interaction in the tail of Acanthamoeba myosin IC between the SH3 domain and a putative pleckstrin homology domain |
Q37339182 | Involvement of headless myosin X in the motility of immortalized gonadotropin-releasing hormone neuronal cells |
Q24314531 | Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids |
Q24293222 | Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins |
Q28207094 | LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin |
Q38395493 | Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes |
Q34001068 | Lipids on the move: phosphoinositide 3-kinases in leukocyte function |
Q28566730 | Localization of myosin 1b to actin protrusions requires phosphoinositide binding |
Q24551785 | Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1 |
Q50335861 | May the force be with you: Myosin-X in phagocytosis. |
Q45099229 | Mechanism of membrane binding of the phospholipase D1 PX domain |
Q27674406 | Membrane Curvature Protein Exhibits Interdomain Flexibility and Binds a Small GTPase |
Q35609309 | Membrane recognition and targeting by lipid-binding domains |
Q29614848 | Membrane recognition by phospholipid-binding domains |
Q34926469 | Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program |
Q73292061 | Membrane targeting: what a difference a G makes |
Q30175408 | Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins |
Q33665566 | Modular PH and C2 domains in membrane attachment and other functions |
Q36858094 | Molecular characteristics of phosphoinositide binding |
Q34057438 | Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain |
Q41764505 | Molecular modelling and site-directed mutagenesis of the inositol 1,3,4,5-tetrakisphosphate-binding pleckstrin homology domain from the Ras GTPase-activating protein GAP1IP4BP |
Q28590542 | Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2 |
Q28592987 | Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation |
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Q30478257 | Myo1c binds phosphoinositides through a putative pleckstrin homology domain |
Q24294845 | Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton |
Q28114999 | Myosin X is a downstream effector of PI(3)K during phagocytosis |
Q30493830 | Myosin X regulates sealing zone patterning in osteoclasts through linkage of podosomes and microtubules |
Q34115035 | Myosin-X is an unconventional myosin that undergoes intrafilopodial motility. |
Q35576442 | Myosin-X: a MyTH-FERM myosin at the tips of filopodia |
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Q28187880 | PI3K in lymphocyte development, differentiation and activation |
Q92173331 | PI3K isoforms in cell signalling and vesicle trafficking |
Q54527804 | PI3K signalling: the path to discovery and understanding. |
Q60921025 | PI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (Review) |
Q34195495 | PI3K: from the bench to the clinic and back |
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Q34459677 | Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs |
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Q92328264 | Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output |
Q34481485 | Phosphoinositide 3-kinase inhibition in cancer treatment |
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Q28206637 | Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1 |
Q35106866 | Phosphoinositide recognition domains |
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Q40291337 | Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing. |
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Q24532099 | Signal-dependent membrane targeting by pleckstrin homology (PH) domains |
Q28141934 | Signalling through phosphoinositide 3-kinases: the lipids take centre stage |
Q33883982 | Small-molecule inhibitors of the PI3K signaling network |
Q42659525 | Specific binding of the C-terminal Src homology 2 domain of the p85alpha subunit of phosphoinositide 3-kinase to phosphatidylinositol 3,4,5-trisphosphate. Localization and engineering of the phosphoinositide-binding motif |
Q35558433 | Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions. |
Q34402004 | Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism. |
Q50335998 | Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain |
Q28363296 | Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor |
Q27679006 | Structural Analyses of the Slm1-PH Domain Demonstrate Ligand Binding in the Non-Canonical Site |
Q22010069 | Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates |
Q27626998 | Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains |
Q27627006 | Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains |
Q24305586 | Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain |
Q27674679 | Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor |
Q28513356 | Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains |
Q24294357 | Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin |
Q55360012 | Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae. |
Q34223205 | T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse |
Q24300968 | TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor |
Q35082143 | The "Gab" in signal transduction. |
Q33940458 | The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase. |
Q27682584 | The Inner Membrane Complex Sub-compartment Proteins Critical for Replication of the Apicomplexan Parasite Toxoplasma gondii Adopt a Pleckstrin Homology Fold |
Q33763339 | The PH superfold: a structural scaffold for multiple functions |
Q40413928 | The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis. |
Q24531972 | The PI3K-PDK1 connection: more than just a road to PKB |
Q24533547 | The Phox homology (PX) domain, a new player in phosphoinositide signalling |
Q36778837 | The Pleckstrin Homology Domain of Diacylglycerol Kinase η Strongly and Selectively Binds to Phosphatidylinositol 4,5-Bisphosphate |
Q30168981 | The Ste20 kinase misshapen regulates both photoreceptor axon targeting and dorsal closure, acting downstream of distinct signals |
Q73456411 | The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity |
Q30159866 | The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans |
Q33943509 | The continued evolution of two-hybrid screening approaches in yeast: how to outwit different preys with different baits |
Q34593973 | The gift of Gab. |
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