Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

scientific article

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/17.18.5374
P932PMC publication ID1170863
P698PubMed publication ID9736615
P5875ResearchGate publication ID13548435

P50authorMark A. LemmonQ24076870
P2093author name stringLi Z
Skolnik EY
Aronheim A
Isakoff SJ
Abagyan R
Cardozo T
Ferguson KM
Andreev J
P2860cites workBAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagementQ24316165
A Grb2-associated docking protein in EGF- and insulin-receptor signallingQ24321653
Association of SET domain and myotubularin-related proteins modulates growth controlQ24323057
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinaseQ24336639
Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemiaQ24532248
Methods for assessing the statistical significance of molecular sequence features by using general scoring schemesQ24558736
Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 betaQ24613360
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85Q24629213
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactionsQ24646252
Structure of the binding site for inositol phosphates in a PH domainQ27729737
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domainQ27732194
The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1)Q27740320
Mammalian Ras interacts directly with the serine/threonine kinase RafQ27860833
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinaseQ28115936
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase BQ28116107
Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunitQ28211409
Signalling through the lipid products of phosphoinositide-3-OH kinaseQ28241516
PH domain: the first anniversaryQ28242218
The PH domain: a common piece in the structural patchwork of signalling proteinsQ28256159
The function of GRB2 in linking the insulin receptor to Ras signaling pathwaysQ28259867
Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinaseQ28268264
A putative modular domain present in diverse signaling proteinsQ28269473
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesisQ28295920
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphateQ28301966
The activation of phosphatidylinositol 3-kinase by RasQ28305326
The role of the PH domain in the signal-dependent membrane targeting of Sos.Q28569671
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domainsQ28591070
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activationQ28616026
Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphateQ28616287
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by VavQ28646540
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101Q28678835
Regulation of neuronal survival by the serine-threonine protein kinase AktQ29614185
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseQ29618387
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transductionQ29618388
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinaseQ29620178
Synergistic activation of dynamin GTPase by Grb2 and phosphoinositidesQ30176283
DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.Q30176932
BTKbase, mutation database for X-linked agammaglobulinemia (XLA).Q30192775
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.Q30194078
A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivoQ30194817
cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptorQ30195693
Homology modeling by the ICM methodQ30424405
A functional screen in yeast for regulators and antagonizers of heterologous protein tyrosine kinasesQ32060776
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domainQ33777007
Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesteraseQ33856733
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domainsQ34436541
Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting.Q34447681
The PROSITE database, its status in 1997.Q34622236
Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brainQ34981771
Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinaseQ36590074
Improved efficiency sos recruitment system: expression of the mammalian GAP reduces isolation of Ras GTPase false positives.Q36873974
Phosphoinositide kinasesQ37902478
Structure-function relationships of the mouse Gap1m. Determination of the inositol 1,3,4,5-tetrakisphosphate-binding domain.Q38354357
Phosphoinositide 3-kinases: a conserved family of signal transducersQ38556727
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.Q39481540
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.Q40020748
Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.Q40023501
Structural Characterization of the Interaction between a Pleckstrin Homology Domain and Phosphatidylinositol 4,5-BisphosphateQ40458847
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?Q40859203
The pleckstrin homology domain: an intriguing multifunctional protein moduleQ40964864
Phosphoinositides as regulators in membrane trafficQ40968891
PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surfaceQ40996433
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signalsQ41037034
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.Q41063499
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.Q41067534
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinaseQ41078571
Phosphoinositide kinasesQ41099687
Inositol phosphates - whither bound? Intracellular signalling.Q41110658
X-linked agammaglobulinemia (XLA): a genetic tyrosine kinase (Btk) diseaseQ41182308
PI3K: downstream AKTion blocks apoptosisQ41351876
The function of inositol high polyphosphate binding proteinsQ41538624
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID miceQ41541610
Unconventional myosins in cell movement, membrane traffic, and signal transductionQ41687083
Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphateQ42061339
Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivoQ42816311
Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signalingQ46765571
Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domainsQ47895700
Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domainQ48047170
Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase ActivityQ54246428
Lipid-Regulated Kinases: Some Common Themes at LastQ57903715
High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase ActivityQ57986498
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteinsQ70787161
Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacityQ71825216
High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphateQ71985042
Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipidQ72223349
Mammalian phosphatidylinositol 3'-kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene productQ72252456
Do aligned sequences share the same fold?Q73876636
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)5374-5387
P577publication date1998-09-01
P1433published inThe EMBO JournalQ1278554
P1476titleIdentification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast
P478volume17

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