Various Themes of Myosin Regulation

scientific article published on 28 January 2016

Various Themes of Myosin Regulation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2016.01.022
P932PMC publication ID4860093
P698PubMed publication ID26827725

P2093author name stringJames R Sellers
Sarah M Heissler
P2860cites workA conserved negatively charged amino acid modulates function in human nonmuscle myosin IIAQ73811675
Myosin Va becomes a low duty ratio motor in the inhibited formQ79960802
Kinetic mechanism of the fastest motor protein, Chara myosinQ80292765
Effect of calcium on calmodulin bound to the IQ motifs of myosin VQ80465025
Motility of myosin V regulated by the dissociation of single calmodulinQ81308489
The structural basis of blebbistatin inhibition and specificity for myosin IIQ81483908
Activation of myosin Va function by melanophilin, a specific docking partner of myosin VaQ81508526
Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylationQ81705155
Three-dimensional structure of the myosin V inhibited state by cryoelectron tomographyQ83177861
Butanedione monoxime suppresses contraction and ATPase activity of rabbit skeletal muscleQ93516185
Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 speciesQ21092862
The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulationQ22008538
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transportQ24295585
Functional characterization of the human myosin-7a motor domainQ24306911
Identification and characterization of multiple novel Rab-myosin Va interactionsQ24322633
Characterization of three full-length human nonmuscle myosin II paralogsQ24337377
Specification of actin filament function and molecular composition by tropomyosin isoformsQ24554294
The chemical biology of protein phosphorylationQ24620636
Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticityQ24655632
The heavy chain has its day: regulation of myosin-II assemblyQ26851306
Allostery in disease and in drug discoveryQ27005770
The myosin superfamily at a glance.Q27011868
Nonmuscle myosin-2: mix and matchQ27022727
Calcium signalling: dynamics, homeostasis and remodellingQ29547635
A FERM domain autoregulates Drosophila myosin 7a activityQ30157340
Acanthamoeba myosin IC colocalizes with phosphatidylinositol 4,5-bisphosphate at the plasma membrane due to the high concentration of negative chargeQ30157528
The myosin I SH3 domain and TEDS rule phosphorylation site are required for in vivo functionQ30176274
Molecular architecture of the chick vestibular hair bundleQ30417485
Myo1c binds tightly and specifically to phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphateQ30477029
Dimerized Drosophila myosin VIIa: a processive motorQ30477237
Myo1c binds phosphoinositides through a putative pleckstrin homology domainQ30478257
Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner earQ30481688
A myosin motor that selects bundled actin for motilityQ30482736
Unconventional myosin traffic in cells reveals a selective actin cytoskeletonQ30488428
Control of cell membrane tension by myosin-I.Q30489048
Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filamentsQ30490501
Single-molecule stepping and structural dynamics of myosin X.Q30494681
Structured post-IQ domain governs selectivity of myosin X for fascin-actin bundlesQ30496161
Cargo binding activates myosin VIIA motor function in cellsQ30499937
Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implicationsQ30540141
Regulation of nonmuscle myosin II by tropomyosinQ30582026
Cardiac myosin activation: a potential therapeutic approach for systolic heart failureQ30583292
Nonmuscle myosin II isoforms coassemble in living cellsQ30584772
Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.Q32066956
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cellsQ33373673
Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke.Q33859154
Myosins: a diverse superfamilyQ33866577
Leveraging the membrane - cytoskeleton interface with myosin-1.Q33965456
Motor domain-dependent localization of myo1b (myr-1).Q34087135
Dual regulation of mammalian myosin VI motor functionQ34087728
Analysis of the role of Ser1/Ser2/Thr9 phosphorylation on myosin II assembly and function in live cellsQ34089336
A small-molecule inhibitor of skeletal muscle myosin II.Q34105257
Walking to work: roles for class V myosins as cargo transportersQ34238805
Skeletal and cardiac muscle contractile activation: tropomyosin "rocks and rolls".Q34272595
Azidoblebbistatin, a photoreactive myosin inhibitor.Q34278121
Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles.Q34285278
Actin structure-dependent stepping of myosin 5a and 10 during processive movementQ27306218
Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathwayQ27315034
Actin age orchestrates myosin-5 and myosin-6 run lengthsQ27316053
Crystal structure of the motor domain of a class-I myosin.Q27639035
Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin ActivityQ27652654
The mechanism of pentabromopseudilin inhibition of myosin motor activityQ27653333
Myosin VI Dimerization Triggers an Unfolding of a Three-Helix Bundle in Order to Extend Its ReachQ27656923
Myosin VI undergoes cargo-mediated dimerizationQ27656929
Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor ActivityQ27670463
Structure of the Rigor Actin-Tropomyosin-Myosin ComplexQ27670842
Crystal structure of the S100A4-nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanismQ27678260
Structure of the regulatory domain of scallop myosin at 2.8 A resolutionQ27731231
Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulationQ27733358
Myosin-V is activated by binding secretory cargo and released in coordination with Rab/exocyst functionQ27940249
Myosin X is a downstream effector of PI(3)K during phagocytosisQ28114999
Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenanceQ28155879
Dissecting temporal and spatial control of cytokinesis with a myosin II InhibitorQ28183531
Calcium, thin filaments, and the integrative biology of cardiac contractilityQ28234995
Tropomyosin isoforms: divining rods for actin cytoskeleton functionQ28256249
Effect of Mts1 on the structure and activity of nonmuscle myosin IIQ28257003
Mechanism of blebbistatin inhibition of myosin IIQ28267628
Specificity of blebbistatin, an inhibitor of myosin IIQ28293974
Transient kinetic analysis of the 130-kDa myosin I (MYR-1 gene product) from rat liver. A myosin I designed for maintenance of tension?Q28369644
Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusionsQ28505690
Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neuronsQ28507993
Mouse class III myosins: kinase activity and phosphorylation sitesQ28512769
Biochemical and motile properties of Myo1b splice isoformsQ28570970
Rat myr 4 defines a novel subclass of myosin I: identification, distribution, localization, and mapping of calmodulin-binding sites with differential calcium sensitivityQ28574546
Myosin surface loop 4 modulates inhibition of actomyosin 1b ATPase activity by tropomyosinQ28579818
Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actinQ28584753
Myosin V: regulation by calcium, calmodulin, and the tail domainQ28588566
Regulation of contraction in striated muscleQ28610114
Identification, phosphorylation, and dephosphorylation of a second site for myosin light chain kinase on the 20,000-dalton light chain of smooth muscle myosinQ28678696
Endogenous species of mammalian nonmuscle myosin IIA and IIB include activated monomers and heteropolymers.Q29347015
Myosin-X provides a motor-based link between integrins and the cytoskeleton.Q34322246
Phototoxicity and photoinactivation of blebbistatin in UV and visible light.Q34331779
para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitorQ34426082
Kinetic characterization of the sole nonmuscle myosin-2 from the model organism Drosophila melanogasterQ34460620
Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI.Q34494423
Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cellsQ34533839
Signaling to myosin regulatory light chain in sarcomeresQ34696210
PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assemblyQ34697985
Insights into modulation of calcium signaling by magnesium in calmodulin, troponin C and related EF-hand proteinsQ34810222
Distinct functional interactions between actin isoforms and nonsarcomeric myosinsQ34907205
Rac1-dependent phosphorylation and focal adhesion recruitment of myosin IIA regulates migration and mechanosensingQ34995897
Tuning myosin-driven sorting on cellular actin networksQ35227173
Robust Mechanosensing and Tension Generation by Myosin VIQ35433502
Myosin II isoform co-assembly and differential regulation in mammalian systemsQ35613068
The cargo-binding domain regulates structure and activity of myosin 5Q35752269
Is allostery an intrinsic property of all dynamic proteins?Q35894622
Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cellsQ35942363
Differential regulation of unconventional fission yeast myosins via the actin track.Q53306564
Regulation of non-muscle myosin assembly by calmodulin-dependent light chain kinase.Q54304184
The S100A4 Metastasis Factor Regulates Cellular Motility via a Direct Interaction with Myosin-IIAQ56531468
Active site trapping of nucleotide by smooth and non-muscle myosinsQ58098217
Light-chain phosphorylation controls the conformation of vertebrate non-muscle and smooth muscle myosin moleculesQ59053614
A model of Ca2+-free calmodulin binding to unconventional myosins reveals how calmodulin acts as a regulatory switchQ60394563
Localization of the three phosphorylation sites on each heavy chain of Acanthamoeba myosin II to a segment at the end of the tailQ70675339
Comparison of the actin binding and filament formation properties of phosphorylated and dephosphorylated Acanthamoeba myosin IIQ72121022
Novel 130-kDa rat liver myosin-1 will translocate actin filamentsQ72459133
Two heads are required for phosphorylation-dependent regulation of smooth muscle myosinQ72466062
Phosphorylation-dependent regulation of Limulus myosinQ72487384
Reversible phosphorylation of smooth muscle myosin, heavy meromyosin, and platelet myosinQ72509689
The interaction of F-actin with phosphorylated and unphosphorylated myosins IA and IB from Acanthamoeba castellaniiQ72559861
Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinaseQ72820086
Regulation of asymmetric smooth muscle myosin II moleculesQ73038449
p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin IQ35987694
Myosins: tails (and heads) of functional diversityQ36197820
Myosin light chain kinase and myosin light chain phosphatase from Dictyostelium: effects of reversible phosphorylation on myosin structure and functionQ36216096
Structural changes accompanying phosphorylation of tarantula muscle myosin filamentsQ36217598
Filamentous smooth muscle myosin is regulated by phosphorylationQ36222189
Calmodulin dissociation regulates brush border myosin I (110-kD-calmodulin) mechanochemical activity in vitroQ36222736
Calcium-calmodulin and regulation of brush border myosin-I MgATPase and mechanochemistryQ36232765
Expression of a myosin regulatory light chain phosphorylation site mutant complements the cytokinesis and developmental defects of Dictyostelium RMLC null cellsQ36235090
A bent monomeric conformation of myosin from smooth muscleQ36315546
A structural model for phosphorylation control of Dictyostelium myosin II thick filament assemblyQ36316308
Membrane-induced lever arm expansion allows myosin VI to walk with large and variable step sizesQ36318743
Visualization of head-head interactions in the inhibited state of smooth muscle myosinQ36326148
Regulation of myosin self-assembly: phosphorylation of Dictyostelium heavy chain inhibits formation of thick filamentsQ36419052
The globular tail domain puts on the brake to stop the ATPase cycle of myosin Va.Q36446088
Regulation of the actin-activated MgATPase activity of Acanthamoeba myosin II by phosphorylation of serine 639 in motor domain loop 2.Q36512132
Regulation of the filament structure and assembly of Acanthamoeba myosin II by phosphorylation of serines in the heavy-chain nonhelical tailpieceQ36512165
Tropomyosin is essential for processive movement of a class V myosin from budding yeastQ36604050
Myosin regulatory light chain phosphorylation enhances cardiac β-myosin in vitro motility under loadQ36683854
Mammalian myosin-18A, a highly divergent myosinQ36725141
Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in diseaseQ36832618
Calcium regulation of calmodulin binding to and dissociation from the myo1c regulatory domainQ36935503
Loop 2 of limulus myosin III is phosphorylated by protein kinase A and autophosphorylationQ36966889
Myosin light chains: Teaching old dogs new tricksQ37021389
Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activityQ37031923
Single-molecule reconstitution of mRNA transport by a class V myosinQ37076266
Kinetic characterization of the ATPase and actin-activated ATPase activities of Acanthamoeba castellanii myosin-2Q37168421
Role of the tail in the regulated state of myosin 2.Q37180838
The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIAQ37208900
More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin VaQ37226089
Inhibition of myosin ATPase by vanadate ionQ37332531
Cargo binding induces dimerization of myosin VI.Q37366472
Avian synaptopodin 2 (fesselin) stabilizes myosin filaments and actomyosin in the presence of ATP.Q37384926
A novel approach to improve cardiac performance: cardiac myosin activatorsQ37398701
Release from myosin V via regulated recruitment of an E3 ubiquitin ligase controls organelle localizationQ37715468
Caldesmon, a novel regulatory protein in smooth muscle and nonmuscle actomyosin systemsQ37770883
Shaking the myosin family tree: biochemical kinetics defines four types of myosin motorQ37946073
Cargo recognition and cargo-mediated regulation of unconventional myosinsQ38250419
Myosin regulatory light chain phosphorylation and the production of functionally significant changes in myosin head arrangement on striated muscle thick filaments.Q39656789
The significance of the slow dissociation of divalent metal ions from myosin ‘regulatory’ light chainsQ40111718
Cyclic AMP-induced phosphorylation inDictyosteliumof a polypeptide comigrating with myosin heavy chainsQ40145540
The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motorQ40270903
TEDS rule: a molecular rationale for differential regulation of myosins by phosphorylation of the heavy chain headQ40410613
Ca2+-induced activation of ATPase activity of myosin Va is accompanied with a large conformational changeQ40587730
Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filamentsQ41260479
The localization and sequence of the phosphorylation sites of Acanthamoeba myosins I. An improved method for locating the phosphorylated amino acidQ41266974
Intermolecular versus intramolecular interactions of Dictyostelium myosin: possible regulation by heavy chain phosphorylationQ41572526
Head-head interaction characterizes the relaxed state of Limulus muscle myosin filamentsQ41622111
Mechanism of the phosphorylation-dependent regulation of smooth muscle heavy meromyosinQ41835950
Small molecule-mediated refolding and activation of myosin motor functionQ41944771
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule levelQ41978648
The kinase domain alters the kinetic properties of the myosin IIIA motorQ42030609
Kinetic properties and small-molecule inhibition of human myosin-6.Q42032109
Comparative kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoformsQ42093317
A Myosin V Inhibitor Based on Privileged Chemical ScaffoldsQ42109184
Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2.Q42155473
The Dictyostelium class I myosin, MyoD, contains a novel light chain that lacks high-affinity calcium-binding sitesQ42157088
Myosin light chain phosphorylation affects the structure of rabbit skeletal muscle thick filamentsQ42536226
Membrane-bound myo1c powers asymmetric motility of actin filamentsQ42554416
Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing bodyQ43052816
Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1.Q43266175
Effect of multiple phosphorylations of smooth muscle and cytoplasmic myosins on movement in an in vitro motility assayQ43472799
Identification of the serine residue phosphorylated by protein kinase C in vertebrate nonmuscle myosin heavy chainsQ43517337
Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in fliesQ43571395
Kinetic mechanism and regulation of myosin VI.Q43651972
Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II.Q43710205
Mechanism of regulation of Acanthamoeba myosin-IC by heavy-chain phosphorylationQ44171738
Cooperativity of actin-activated ATPase of gizzard heavy meromyosin in the presence of gizzard tropomyosinQ44278523
2,3-Butanedione monoxime (BDM) as a myosin inhibitorQ44358175
Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb.Q45150955
Magnesium regulates ADP dissociation from myosin V.Q45173714
Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosinQ45173722
Myosin VI altered at threonine 406 stabilizes actin filaments in vivoQ46044406
Fesselin binds to actin and myosin and inhibits actin-activated ATPase activity.Q46717115
Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivoQ46832088
Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosisQ46917024
Drosophila myosin-XX functions as an actin-binding protein to facilitate the interaction between Zyx102 and actinQ47072803
Regulated conformation of myosin V.Q47368896
High affinity Ca2+ binding sites of calmodulin are critical for the regulation of myosin Ibeta motor functionQ47761184
Mechanism, regulation, and functional properties of Dictyostelium myosin-1B.Q48019624
Differential regulation of skeletal muscle myosin-II and brush border myosin-I enzymology and mechanochemistry by bacterially produced tropomyosin isoformsQ48086775
Two nonmuscle myosin II heavy chain isoforms expressed in rabbit brains: filament forming properties, the effects of phosphorylation by protein kinase C and casein kinase II, and location of the phosphorylation sitesQ48521726
Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light.Q50486788
Two distinct mechanisms for regulation of nonmuscle myosin assembly via the heavy chain: phosphorylation for MIIB and mts 1 binding for MIIA.Q52165275
PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation.Q52604153
Phospholipid-dependent regulation of the motor activity of myosin X.Q52612413
P433issue9 Pt B
P407language of work or nameEnglishQ1860
P304page(s)1927-1946
P577publication date2016-01-28
P1433published inJournal of Molecular BiologyQ925779
P1476titleVarious Themes of Myosin Regulation
P478volume428

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cites work (P2860)
Q47074148A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B.
Q48506649Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties
Q51739760Chlamydia trachomatis inclusion membrane protein MrcA interacts with the inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) to regulate extrusion formation.
Q92408517Common and Specific Functions of Nonmuscle Myosin II Paralogs in Cells
Q48519050Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer
Q52676165Distinct sites in tropomyosin specify shared and isoform-specific regulation of myosins II and V.
Q36236204Drosophila non-muscle myosin II motor activity determines the rate of tissue folding
Q58763345E-hooks provide guidance and a soft landing for the microtubule binding domain of dynein
Q48297251INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division
Q50422621Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals
Q38963256Investigations of human myosin VI targeting using optogenetically controlled cargo loading
Q41048804Kinetic adaptation of human Myo19 for active mitochondrial transport to growing filopodia tips
Q47695282Kinetic signatures of myosin-5B, the motor involved in microvillus inclusion disease
Q52650595Mammalian nonmuscle myosin II comes in three flavors.
Q52561235Myocyte enhancer factor 2A promotes proliferation and its inhibition attenuates myogenic differentiation via myozenin 2 in bovine skeletal muscle myoblast.
Q48112545Non-muscle (NM) myosin heavy chain phosphorylation regulates the formation of NM myosin filaments, adhesome assembly and smooth muscle contraction
Q90702016Optimized filopodia formation requires myosin tail domain cooperation
Q52597816Ordering of myosin II filaments driven by mechanical forces: experiments and theory.
Q90642008Overexpression of Myo1e promotes albumin endocytosis by mouse glomerular podocytes mediated by Dynamin
Q64071117Processivity vs. Beating: Comparing Cytoplasmic and Axonemal Dynein Microtubule Binding Domain Association with Microtubule
Q41047666ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain.
Q39449551Regulation of class V myosin.
Q83227757TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium
Q47355011Tension, contraction and tissue morphogenesis
Q90051193The Physical Mechanisms of Drosophila Gastrulation: Mesoderm and Endoderm Invagination
Q58562428The actomyosin network is influenced by NMHC IIA and regulated by Crp, which is involved in controlling cell migration
Q92459616The central role of the tail in switching off 10S myosin II activity
Q48193094The fungal myosin I is essential for Fusarium toxisome formation.
Q37678046Thermodynamic aspects of ATP hydrolysis of actomyosin complex
Q88453324Thick Filament Protein Network, Functions, and Disease Association
Q92156441Unconventional Myosins: How Regulation Meets Function

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