Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis

scientific article

Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis is …
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scholarly articleQ13442814

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P819ADS bibcode2002PNAS...99.2193B
P356DOI10.1073/PNAS.261704098
P3181OpenCitations bibliographic resource ID2829544
P932PMC publication ID122341
P698PubMed publication ID11854515
P5875ResearchGate publication ID11506165

P50authorAjit VarkiQ4699812
Richard HynesQ2150305
P2093author name stringAjit Varki
Nissi M Varki
Lubor Borsig
Richard Wong
P2860cites workHeparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasisQ24630993
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Role of plasma, platelets, and endothelial cells in tumor metastasisQ28267439
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Sulfated Glycolipids Are Ligands for a Lymphocyte Homing Receptor, L-Selectin (LECAM-1), Binding Epitope in Sulfated Sugar ChainQ28581968
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversityQ29617967
L-selectin shedding regulates leukocyte recruitmentQ30307158
Sequential contribution of L- and P-selectin to leukocyte rolling in vivoQ30463937
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P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancerQ34171030
L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesisQ35049150
Platelets and cancer metastasis: a causal relationship?Q35477800
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment.Q35651662
P-selectin deficiency attenuates tumor growth and metastasisQ36257237
Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectinQ36361481
Redirection of tumor metastasis by expression of E-selectin in vivoQ36366262
Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrinsQ36534910
Selectin ligands: will the real ones please stand up?Q37362400
Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials.Q38312162
In vitro and in vivo selectin-blocking activities of sulfated lipids and sulfated sialyl compoundsQ38336021
Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitmentQ39787876
Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agentsQ39799215
Possible roles of tumor-associated carbohydrate antigens.Q40984154
P-selectin-mediated attachment of small cell lung carcinoma to endothelial cellsQ41147195
A role for L-selectin in monocyte activation by Jurkat tumour cellsQ41148129
Selectins and their ligands: current concepts and controversies.Q41192497
Mucin glycoproteins in neoplasiaQ41204090
Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolismQ41270282
Selectin ligands, leukocyte trafficking, and fucosyltransferase genesQ41469716
Perspectives on the significance of altered glycosylation of glycoproteins in cancerQ41594921
Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer.Q41594926
CD62/P-selectin binding sites for myeloid cells and sulfatides are overlappingQ41660720
CD62/P-selectin recognition of myeloid and tumor cell sulfatidesQ41661588
Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinaseQ41666167
Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endotheliumQ41683514
A novel detection system for submicroscopic human metastases in athymic miceQ41701863
Selectins and mechanisms of signal transductionQ41704133
Biosynthesis and turnover of O-acetyl and N-acetyl groups in the gangliosides of human melanoma cells.Q41725288
Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lectureQ42615524
Characterization of human colon carcinoma variant cells selected for sialyl Lex carbohydrate antigen: liver colonization and adhesion to vascular endothelial cellsQ42803284
Murine Colon Adenocarcinomas: Methods for Selective Culture In Vitro 2Q42803902
Inhibition of colon carcinoma cell lung colony formation by a soluble form of E-selectin.Q42840045
Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo.Q42944436
Dimeric sialyl-Le(x) expression in gastric carcinoma correlates with venous invasion and poor outcomeQ43512005
Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins.Q46012118
Expression of L-selectin and efficient binding to high endothelial venules do not modulate the dissemination potential of murine B-cell lymphoma.Q52019310
Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditionsQ58830562
Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factorsQ60673557
Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling moleculeQ71609722
Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endotheliumQ72067065
Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical studyQ72226978
L-selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses in vivoQ73306889
The effects of unfractionated heparin on survival in patients with malignancy--a systematic reviewQ73307814
Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasisQ73308234
L-selectin signaling of neutrophil adhesion and degranulation involves p38 mitogen-activated protein kinaseQ73626614
Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathwaysQ74557624
Lysis of tumor cells by natural killer cells in mice is impeded by plateletsQ74650896
Inhibition of metastases by anticoagulantsQ77798656
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttumor metastasisQ120912381
P1104number of pages6
P304page(s)2193-2198
P577publication date2002-02-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSynergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis
P478volume99

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