RLIP76, a non-ABC transporter, and drug resistance in epilepsy

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RLIP76, a non-ABC transporter, and drug resistance in epilepsy is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1027036062
P356DOI10.1186/1471-2202-6-61
P932PMC publication ID1249579
P698PubMed publication ID16188027
P5875ResearchGate publication ID7576493

P50authorDamir JanigroQ37378626
P2093author name stringLuca Cucullo
Sanjay Awasthi
Yogesh C Awasthi
Vince Fazio
Sharad S Singhal
Gabriele Dini
Kerri L Hallene
P2860cites workNovel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicinQ22254720
RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytesQ24291401
Epileptogenicity of focal malformations due to abnormal cortical development: direct electrocorticographic-histopathologic correlationsQ48390144
Focal cortical dysplasias in eloquent cortex: functional characteristics and correlation with MRI and histopathologic changesQ48669501
Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.Q48669608
Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.Q53859498
Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activityQ24337472
Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPasesQ24651430
Significance of MDR1 and multiple drug resistance in refractory human epileptic brainQ24804381
RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosisQ28141762
Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76Q28182524
Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicityQ28182550
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cellsQ28203126
RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosisQ28207629
Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomesQ28208524
Carbamazepine is not a substrate for P-glycoproteinQ28363548
A putative effector of Ral has homology to Rho/Rac GTPase activating proteinsQ28512740
Cytocentrin is a Ral-binding protein involved in the assembly and function of the mitotic apparatusQ28579981
Interaction of antiepileptic drugs with human P-glycoprotein in vitroQ31155945
P-Glycoprotein, a gatekeeper in the blood-brain barrierQ33904245
ABC transporters and the blood-brain barrierQ33978165
POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosisQ34393707
Drug resistance in epilepsy: the role of the blood-brain barrierQ34624873
The problem of the drug-resistant epilepsiesQ34624880
Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76).Q35052499
Mechanisms of antiepileptic drug resistanceQ35088259
Vascular and Parenchymal Mechanisms in Multiple Drug Resistance: a Lesson from Human EpilepsyQ35109033
Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistanceQ35179100
Role of 4-hydroxynonenal in stress-mediated apoptosis signalingQ35189540
Potential role of drug transporters in the pathogenesis of medically intractable epilepsyQ36023613
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugsQ37355653
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse modelQ38448723
RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer.Q40459619
RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistanceQ40512245
The molecular interaction of the high affinity reversal agent XR9576 with P-glycoproteinQ42031200
P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brainQ43815938
Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal.Q44209469
Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activityQ44381534
Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cellsQ46551004
RLIP76 is a major determinant of radiation sensitivityQ46604639
Relationship between expression of multiple drug resistance proteins and p53 tumor suppressor gene proteins in human brain astrocytesQ48168333
Dynamic in vitro model of the blood-brain barrier. Gene profiling using cDNA microarray analysisQ48206066
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdrug resistanceQ12147416
P304page(s)61
P577publication date2005-09-27
P1433published inBMC NeuroscienceQ15766477
P1476titleRLIP76, a non-ABC transporter, and drug resistance in epilepsy
P478volume6

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cites work (P2860)
Q28538154Amelioration of cancer stem cells in macrophage colony stimulating factor-expressing U87MG-human glioblastoma upon 5-fluorouracil therapy
Q30481778Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis
Q37875183Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: a synergistic role in neurological diseases.
Q37104987CYP3A5*3 and C3435T MDR1 polymorphisms in prognostication of drug-resistant epilepsy in children and adolescents
Q36341748Challenges and opportunities in the application of pharmacogenetics to antiepileptic drug therapy
Q38178326Development of individualized medicine for epilepsy based on genetic information
Q33997439Drug delivery to brain tumours: challenges and progress
Q37362486Drug interactions at the blood-brain barrier: fact or fantasy?
Q37900131Drug resistance in epilepsy and the ABCB1 gene: The clinical perspective.
Q36555922Genetic association studies in epilepsy pharmacogenomics: lessons learnt and potential applications
Q35351642Genetic polymorphism of drug refractory epilepsy
Q35787969Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells.
Q39215770Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells
Q30361123Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
Q47177557Mir-pharmacogenetics of Vincristine and peripheral neurotoxicity in childhood B-cell acute lymphoblastic leukemia.
Q36895830Multidrug resistance in epilepsy: a pharmacogenomic update
Q39752034Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow
Q42157342PharmGKB summary: carbamazepine pathway
Q38544300Pharmacoresistant Epilepsy: A Current Update on Non-Conventional Pharmacological and Non-Pharmacological Interventions
Q37698426Physiological and pharmacological significance of glutathione-conjugate transport
Q34237989Polymorphism of ABCB1/MDR1 C3435T in children and adolescents with partial epilepsy is due to different criteria for drug resistance - preliminary results
Q37181571RLIP76 Gene Variants are not Associated with Drug Response in Turkish Epilepsy Patients
Q37217140RLIP76 and Cancer
Q33867008RLIP76: a versatile transporter and an emerging target for cancer therapy
Q45884490RNAi inhibits Coriaria lactone-induced MDR1b overexpression in rat brain microvascular endothelial cells
Q46845981The association between polymorphisms in RLIP76 and drug response in epilepsy
Q42524620White matter angiopathy is common in pediatric patients with intractable focal epilepsies

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