RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis

scientific article (publication date: 15 August 2003)

RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M302191200
P8608Fatcat IDrelease_pdeqyoerjjf4dodibpymij5tly
P698PubMed publication ID12775724

P2093author name stringJacques Camonis
Sébastien L'Hoste
Nicolas Offner
Carine Rossé
André Picard
P2860cites workIdentification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of RalQ24318512
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptorsQ24534185
Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles.Q24539890
Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451Q24548249
Numb is an endocytic proteinQ24681102
Mammalian Ras interacts directly with the serine/threonine kinase RafQ27860833
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cellsQ28208373
An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1Q28256262
Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2Q28301582
The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminalsQ28579210
Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylationQ33898116
Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerizationQ33900263
Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathwaysQ33969356
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in DrosophilaQ34145953
A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathwaysQ34463200
Distinct requirements for Ras oncogenesis in human versus mouse cellsQ34787097
Mitotic cytosol inhibits invagination of coated pits in broken mitotic cellsQ36530252
Monoclonal antibodies to mitotic cellsQ37611790
cdc2 links the Drosophila cell cycle and asymmetric division machineriesQ42500731
Phosphorylation states of microtubule-associated protein 2 (MAP2) determine the regulatory role of MAP2 in microtubule dynamicsQ48605036
Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathologyQ48818986
Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinaseQ57985211
The exocyst is a Ral effector complexQ77342588
P433issue33
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
endocytosisQ189814
Cyclin B Dmel_CG3510Q29812877
Ral interacting protein Dmel_CG11622Q29813326
Numb Dmel_CG3779Q29819495
P304page(s)30597-604
P577publication date2003-08-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleRLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis
P478volume278

Reverse relations

cites work (P2860)
Q33688521A central role of RLIP76 in regulation of glycemic control.
Q37323126A requirement for epsin in mitotic membrane and spindle organization
Q40543259Activation of Ras-Ral pathway attenuates p53-independent DNA damage G2 checkpoint.
Q39777040Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA
Q37158871Breaking up is hard to do - membrane traffic in cytokinesis.
Q42136455Breaking up is hard to do: RalA, mitochondrial fission and cancer
Q24337038Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs
Q34556062Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter
Q39415229Endocytic adaptor protein epsin is elevated in prostate cancer and required for cancer progression
Q36926955Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells
Q28307353Epsin Family of Endocytic Adaptor Proteins as Oncogenic Regulators of Cancer Progression
Q30445918Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins
Q34164071Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits
Q37146994Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates
Q34729947Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
Q33689727Human RAS superfamily proteins and related GTPases
Q34193705Identification and characterization of the RLIP/RALBP1 interacting protein Xreps1 in Xenopus laevis early development
Q24305261Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb
Q35730239Identification of genes that interact with Drosophila liquid facets
Q39859514Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis
Q38936969Knockdown of CDC2 expression inhibits proliferation, enhances apoptosis, and increases chemosensitivity to temozolomide in glioblastoma cells
Q37874698Mitotic moonlighting functions for membrane trafficking proteins
Q34568457Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis
Q35628908Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence
Q36129973Overexpression of RalBP1 in colorectal cancer is an independent predictor of poor survival and early tumor relapse
Q37698426Physiological and pharmacological significance of glutathione-conjugate transport
Q42063703Predicting physical interactions between protein complexes
Q47785451Protein adaptation: mitotic functions for membrane trafficking proteins
Q30503960RALA and RALBP1 regulate mitochondrial fission at mitosis
Q36322720RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization
Q30444197RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration
Q37181571RLIP76 Gene Variants are not Associated with Drug Response in Turkish Epilepsy Patients
Q39225715RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma
Q37741408RLIP76 Targeted Therapy for Kidney Cancer
Q37217140RLIP76 and Cancer
Q37146998RLIP76 in defense of radiation poisoning
Q39218553RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis
Q34023922RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome
Q24533543RLIP76, a non-ABC transporter, and drug resistance in epilepsy
Q37146979RLIP76: A novel glutathione-conjugate and multi-drug transporter
Q33867008RLIP76: a versatile transporter and an emerging target for cancer therapy
Q42055537Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C.
Q92760791Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system
Q28294053Ral GTPases in tumorigenesis: emerging from the shadows
Q42325465Ral inhibits ligand-independent Notch signaling in Drosophila
Q34363605Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame
Q24337344RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly
Q37194622Regression of prostate cancer xenografts by RLIP76 depletion
Q52724571Rlip depletion prevents spontaneous neoplasia in TP53 null mice.
Q30051796Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76
Q39741584Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis
Q37154223Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death.
Q48520108Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling
Q38336615Targeting p53-null neuroblastomas through RLIP76.
Q39209358Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer
Q42832946The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration
Q35867942The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector
Q35083727The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery
Q27680559The Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the Membrane
Q33864158The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin
Q30482500The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis.
Q24295295The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion
Q36609767Therapeutic resistance in lung cancer
Q36642347Vestiges of Ent3p/Ent5p function in the giardial epsin homolog

Search more.