Breaking up is hard to do: RalA, mitochondrial fission and cancer

scientific article published on November 2011

Breaking up is hard to do: RalA, mitochondrial fission and cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/SGTP.18284
P8608Fatcat IDrelease_ufg5hhyxjzclja4pfiyysvxek4
P932PMC publication ID3337163
P698PubMed publication ID22545232
P5875ResearchGate publication ID224868838

P2093author name stringChristopher M Counter
David F Kashatus
P2860cites workThe small GTPase RalA targets filamin to induce filopodiaQ22008839
The tumor suppressor PP2A Abeta regulates the RalA GTPaseQ24307546
Activated Ras interacts with the Ral guanine nucleotide dissociation stimulatorQ24308694
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1Q24309607
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assemblyQ24337344
RAL GTPases are linchpin modulators of human tumour-cell proliferation and survivalQ24536042
RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activityQ24557505
Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and RapQ24564137
Coding sequences of human ralA and ralB cDNAsQ24635845
Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPasesQ24651430
Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to boneQ24681479
Mechanisms of mitophagyQ27310261
Ral GTPases regulate exocyst assembly through dual subunit interactionsQ28207098
RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosisQ28207629
Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cellsQ28208373
Raf-1 activates MAP kinase-kinaseQ28211351
The exocyst complex binds the small GTPase RalA to mediate filopodia formationQ28211412
The molecular machinery of mitochondrial fusion and fission: An opportunity for drug discovery?Q28257781
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancersQ28272347
Mitochondrial fusion and fission in cell life and deathQ28299119
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanismsQ28384212
ras oncogenes in human cancer: a reviewQ29547769
Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseasesQ29615646
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.Q29616569
Phosphatidylinositol-3-OH kinase as a direct target of RasQ29620177
Ras history: The saga continuesQ30404024
Phosphorylation of RalB Is Important for Bladder Cancer Cell Growth and MetastasisQ30429890
RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cellsQ30449192
A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phaseQ30488844
RALA and RALBP1 regulate mitochondrial fission at mitosisQ30503960
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitroQ33292215
Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNAQ33370933
Ral activation promotes melanomagenesisQ34086528
Mitochondrial shape changes: orchestrating cell pathophysiology.Q34106103
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survivalQ34571216
Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.Q34592093
Distinct requirements for Ras oncogenesis in human versus mouse cellsQ34787097
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvationQ35064216
The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug DiscoveryQ35083727
Mitochondrial fission in apoptosisQ36198122
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationQ36496658
Ral GTPases and cancer: linchpin support of the tumorigenic platformQ37064855
The Aurora kinase family in cell division and cancer.Q37228956
Mitochondrial dynamics in mammalian health and diseaseQ37543838
The changing shape of mitochondrial apoptosisQ37568897
Mitochondrial fission/fusion dynamics and apoptosisQ37781431
Molecular mechanisms and physiologic functions of mitochondrial dynamicsQ37828305
Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironmentQ37892504
Activation and involvement of Ral GTPases in colorectal cancerQ38338335
RalA function in dermal fibroblasts is required for the progression of squamous cell carcinoma of the skin.Q39619874
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalAQ39777040
Ral overactivation in malignant peripheral nerve sheath tumorsQ39856973
MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinasesQ40005270
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.Q40315264
Activation of RalA is critical for Ras-induced tumorigenesis of human cells.Q40410788
RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.Q40439740
RalGDS is required for tumor formation in a model of skin carcinogenesis.Q40447001
Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening.Q40473985
ralGDS family members interact with the effector loop of ras p21.Q41431568
The Rgr oncogene induces tumorigenesis in transgenic miceQ42825949
C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.Q48120347
Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.Q53381806
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.Q53571110
Dynamics of mitochondria during the cell cycle.Q53601952
Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinomaQ73501765
The exocyst is a Ral effector complexQ77342588
miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1Q83034995
P433issue6
P1104number of pages5
P304page(s)329-333
P577publication date2011-11-01
P1433published inSmall GTPases (journal)Q15709529
P1476titleBreaking up is hard to do: RalA, mitochondrial fission and cancer
P478volume2