Numb Dmel_CG3779

Protein found in Drosophila melanogaster

Numb Dmel_CG3779 is …
instance of (P31):
proteinQ8054

External links are
P705Ensembl protein IDFBpp0079419
FBpp0079420
FBpp0308609
P637RefSeq protein IDNP_001260291
NP_523523
NP_723460
P352UniProt protein IDP16554

P682biological processNotch signaling pathwayQ904082
asymmetric cell divisionQ4812070
cell fate determinationQ5058196
central nervous system developmentQ14330967
protein localizationQ14599379
multicellular organism developmentQ14645705
negative regulation of neuroblast proliferationQ14818026
heart developmentQ14819288
glial cell migrationQ14819482
negative regulation of gene expressionQ14819859
neuroblast proliferationQ14859921
cell fate commitmentQ14860192
positive regulation of endocytosisQ14862251
rhythmic behaviorQ14863667
regulation of asymmetric cell divisionQ14864651
peripheral nervous system developmentQ14873924
embryonic heart tube developmentQ14902766
negative regulation of Notch signaling pathwayQ14903090
regulation of Notch signaling pathwayQ14907593
regulation of neurogenesisQ14916220
centrosome localizationQ21097553
regulation of neuroblast proliferationQ21109315
negative regulation of receptor recyclingQ21109464
neuroblast fate determinationQ21111612
enteroendocrine cell differentiationQ21118833
muscle cell fate specificationQ21120851
regulation of nervous system developmentQ21433509
asymmetric neuroblast divisionQ22295918
sensory organ precursor cell divisionQ22295923
sensory organ precursor cell fate determinationQ22296023
neuroblast developmentQ22296202
pericardial nephrocyte differentiationQ22297599
Malpighian tubule tip cell differentiationQ22297612
ventral cord developmentQ22298591
P681cell componentnucleusQ40260
cytoplasmQ79899
cell cortexQ5058180
basal part of cellQ14860546
basal cortexQ21103311
P702encoded bynumbQ29731192
P703found in taxonDrosophila melanogasterQ130888
P527has part(s)PTB/PI domainQ24742225
NUMB domainQ24775588
P680molecular functionprotein bindingQ167149
ATP bindingQ14817981
nucleotide bindingQ14860365
Notch bindingQ14914607
P361part ofNumb/numb-likeQ24738886
PH-like domain superfamilyQ24786013
PTB/PI domain, protein familyQ83137700
NUMB domain, protein familyQ83145648

Reverse relations

main subject (P921)
Q34283032A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.
Q43123066Ancestry-independent fate specification and plasticity in the developmental timing of a typical Drosophila neuronal lineage
Q35221182Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
Q28286748Control of daughter cell fates during asymmetric division: interaction of Numb and Notch
Q41073451Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.
Q37593628Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors
Q47072023Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
Q38770014Intrinsic regulation of enteroendocrine fate by Numb.
Q47072557Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila
Q34788601Mechanisms of spindle positioning: focus on flies and worms
Q47071706Multiple signalling pathways establish cell fate and cell number in Drosophila malpighian tubules
Q47071424Notch and Numb are required for normal migration of peripheral glia in Drosophila
Q37120525Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff
Q43205606Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs
Q34392095Numb antagonizes Notch signaling to specify sibling neuron cell fates
Q33689806Numb independently antagonizes Sanpodo membrane targeting and Notch signaling in Drosophila sensory organ precursor cells
Q47071916Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila
Q33724489Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway.
Q37259869Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells
Q39631431Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo
Q40219692Polarized endosome dynamics by spindle asymmetry during asymmetric cell division
Q47071776Quantitative analysis of protein dynamics during asymmetric cell division
Q28207629RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis
Q47072789Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division
Q41769266Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs
Q42177502Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions
Q41717902The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
Q36106839Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway
Q24338740aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb
Q47071684bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

Q29731192numbencodesP688

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