Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.

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Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.23.3.852-863.2003
P932PMC publication ID140705
P698PubMed publication ID12529391

P50authorPeter Joseph Jacques ParkerQ21165177
Alexander D LutsykQ61086852
Tim R FentonQ62760330
Christopher G. ProudQ30502222
Valeriy FilonenkoQ37375999
Rainer CramerQ37383590
P2093author name stringHeike Rebholz
Lijun Wang
Taras Valovka
Mong-Lien Wang
Frederique Verdier
Alexander Zhyvoloup
Ivan T Gout
Genadiy Matsuka
Miechyslav Gzhegotsky
P2860cites workMolecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich regionQ22004267
Transport between the cell nucleus and the cytoplasmQ22065411
Phosphorylation and activation of p70s6k by PDK1Q24323433
Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.Q24514761
The extended protein kinase C superfamilyQ24530820
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.Q24535599
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1Q24682697
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeletonQ24685127
Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathwayQ28139573
Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylationQ28139589
Characterization of S6K2, a novel kinase homologous to S6K1Q28144592
Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of AktQ28144601
Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alphaQ28208587
Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cellsQ28213233
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinaseQ28244045
Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytesQ28254946
Nucleocytoplasmic transportQ28275907
Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zetaQ28280588
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1Q28283323
Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptorsQ28343899
p70s6k function is essential for G1 progressionQ59054463
EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicityQ69348674
Preferential utilization of phosphorylated 40-S ribosomal subunits during initiation complex formationQ70336368
Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive stepsQ73630601
Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways. MEK-dependent activation of S6K2 in cardiomyocytesQ28576562
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BADQ28592766
Protein kinase C: structure, function, and regulationQ28618608
Nucleocytoplasmic transport: signals, mechanisms and regulationQ29547904
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanismQ29614737
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transductionQ29618388
The role of protein kinase C in cell surface signal transduction and tumour promotionQ29618532
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase CQ29620247
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylationQ30453740
Analysis of phospho- and glycopolypeptides with infrared matrix-assisted laser desorption and ionizationQ31954648
Ribosomal S6 kinase signaling and the control of translationQ33783527
Regulation of nuclear localization: a key to a doorQ33804320
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinaseQ33890035
p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complexQ33957763
The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.Q34383423
The modular phosphorylation and activation of p70s6k.Q34434557
In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresisQ34549159
Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiationQ35842286
How proteins enter the nucleusQ37632736
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrestQ40445843
Mitogenesis and protein synthesis: a role for ribosomal protein S6 phosphorylation?Q40582045
Nuclear localization of p85s6k: functional requirement for entry into S phase.Q40791371
Among translational effectors, p70S6k is uniquely sensitive to inhibition by glucocorticoidsQ40889077
The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signallingQ40974450
Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylationQ41034632
Regulation of protein transport to the nucleus: central role of phosphorylationQ41075705
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.Q41106936
Control of p70 s6 kinase by kinase activity of FRAP in vivoQ41284168
Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expressionQ41436483
Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sitesQ41666761
Atypical protein kinase Clambda binds and regulates p70 S6 kinaseQ42141390
The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.Q42812980
Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulinQ42820228
Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol estersQ42832181
Phosphorylation at the nuclear localization signal of Ca2+/calmodulin-dependent protein kinase II blocks its nuclear targetingQ46289164
Drosophila S6 kinase: a regulator of cell sizeQ47072437
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient miceQ47222234
Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodiesQ47954202
Stimulation of protein synthesis in pituitary cells by phorbol esters and cyclic AMP. Evidence for rapid induction of a component of translational initiationQ48172182
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
phosphorylationQ242736
P304page(s)852-863
P577publication date2003-02-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleProtein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization
P478volume23

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cites work (P2860)
Q37165934A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network
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Q46868178Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals
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Q89697546Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer
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Q36677930Identification of S6K2 as a centrosome-located kinase
Q92276992Inhibition of protein kinase C activity inhibits osteosarcoma metastasis
Q44745867Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis
Q39724708Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway
Q33903835Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
Q42042015Molecular Characterization and Expression Analysis of S6K1 in Cashmere Goats (Capra hircus).
Q28256601Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17
Q47131231Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders
Q36157339Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity
Q28255399Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
Q38329337S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver
Q39169842S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo.
Q36713845S6 kinase 2 potentiates interleukin-3-driven cell proliferation
Q100512512S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer
Q24603083S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
Q38125196S6K2: The Neglected S6 Kinase Family Member
Q54118148Signaling pathways involved in the regulation of mRNA translation.
Q28297621Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism
Q36243338Time-varying causal inference from phosphoproteomic measurements in macrophage cells

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