Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells

scientific article

Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.21.15.4856-4867.2001
P932PMC publication ID87191
P698PubMed publication ID11438643
P5875ResearchGate publication ID11901839

P2093author name stringZ Wang
M Bar-Eli
M Ruiz
O Nyormoi
D Doan
D McConkey
P2860cites workGenomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)Q22253285
An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2Q24308857
Cloning and characterization of a second AP-2 transcription factor: AP-2 betaQ24309166
Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expressionQ24310632
RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2.Q24522518
Caspases: the executioners of apoptosisQ24530218
Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressorQ24554732
Transcriptional activation by Myc is under negative control by the transcription factor AP-2Q24568331
Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosisQ24647389
Lamin proteolysis facilitates nuclear events during apoptosisQ24681695
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosisQ24683768
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressorQ27933631
Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factorsQ28116721
Mammalian caspases: structure, activation, substrates, and functions during apoptosisQ28139429
TNF-induced signaling in apoptosisQ28142549
Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2Q28144968
Analysis of the DNA-binding and activation properties of the human transcription factor AP-2Q28271397
Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosisQ28296478
Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritisQ28369400
Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activationQ28379199
Transcription factor AP-2 essential for cranial closure and craniofacial developmentQ28513302
Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2betaQ28591284
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2Q28594321
Cleavage of focal adhesion kinase by caspases during apoptosisQ28610850
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosisQ29614983
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosisQ29617776
Caspase and calpain substrates: roles in synaptic plasticity and cell deathQ33734817
The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosisQ33803124
Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficienciesQ33835849
Transcription factor AP-2 activity is modulated by protein kinase A-mediated phosphorylation.Q33853003
Role of AP-2 in tumor growth and metastasis of human melanomaQ33865634
Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interferenceQ33957311
Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigenQ34163571
Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elementsQ34164797
The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinomaQ34725896
Localization of the gene for the DNA-binding protein AP-2 to human chromosome 6p22.3-pterQ34929338
Developmental regulation of transcription factor AP-2 duringXenopus laevisembryogenesisQ35770598
p22/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosisQ36641213
Alternative mRNAs encode multiple isoforms of transcription factor AP-2 during murine embryogenesis.Q36703622
Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 geneQ37045364
The site of cAMP action in the insulin induction of gene expression of acetyl-CoA carboxylase is AP-2.Q38316793
STAT1 is inactivated by a caspaseQ38337795
Proteolytic cleavage of the mdm2 oncoprotein during apoptosisQ38343171
High levels of AP-2-binding activity in cell lines infected with human T-cell leukemia virus type I: possible enhancement of AP-2 binding by human T-cell leukemia virus type I tax.Q38361617
Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancerQ38466179
PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation.Q39727130
A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour linesQ40873102
Opposite transcriptional activity between the wild type c-myc gene coding for c-Myc1 and c-Myc2 proteins and c-Myc1 and c-Myc2 separatelyQ40922480
Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosisQ40963135
Phenylethanolamine N-methyltransferase gene expression: synergistic activation by Egr-1, AP-2 and the glucocorticoid receptorQ40998289
Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitroQ41075568
Programming gene expression in developing epidermisQ42476595
Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.Q43554604
Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma.Q44314802
Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways.Q45345476
AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expressionQ45345486
Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.Q46001099
Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cellsQ47954377
AP-2.2: a novel AP-2-related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cellsQ48063172
Proteolytic cleavage of beta-catenin by caspases: an in vitro analysisQ49170064
Downregulation of transcription factor AP-2 predicts poor survival in stage I cutaneous malignant melanoma.Q50857224
A novel alternative spliced variant of the transcription factor AP2alpha is expressed in the murine ocular lens.Q52183893
Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb buds.Q52192985
The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells.Q52573380
N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation.Q53472029
Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free ConditionsQ58289992
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1Q59341249
Apoptosis induced by the nuclear death domain protein p84N5 is associated with caspase-6 and NF-kappa B activationQ64380730
Redox modulation of AP-2 DNA binding activity in vitro.Q64993609
Proteolytic activity in amyotrophic lateral sclerosis IgG preparationsQ71864942
Substrate specificities of caspase family proteasesQ73201753
Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1)Q73283365
Molecular mechanisms of melanoma metastasisQ73868474
CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaBQ74309691
Transcription factor AP-2 mRNA and DNA binding activity are constitutively expressed in SV40-immortalized but not normal human lung fibroblastsQ77222701
CREB and its associated proteins act as survival factors for human melanoma cellsQ77229224
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
apoptotic processQ14599311
P304page(s)4856-67
P577publication date2001-08-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleTranscription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells
P478volume21

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cites work (P2860)
Q28742161A quantitative method for the specific assessment of caspase-6 activity in cell culture
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Q35173065Therapeutic approaches to bladder cancer: identifying targets and mechanisms
Q53554762pC6-2/caspase-6 system to purify glutathione-S-transferase-free recombinant fusion proteins expressed in Escherichia coli.

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