Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase

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Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase is …
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scholarly articleQ13442814

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P819ADS bibcode2001PNAS...9813595J
P356DOI10.1073/PNAS.251539398
P953full work available at URLhttps://europepmc.org/articles/pmc61086?pdf=render
P3181OpenCitations bibliographic resource ID2571277
P932PMC publication ID61086
P698PubMed publication ID11707604
P5875ResearchGate publication ID11646677

P7228access restriction statusopen accessQ232932
P2093author name stringR M Williams
R B Croteau
S Jennewein
C D Rithner
P2860cites workMolecular cloning and heterologous expression of a cDNA encoding berbamunine synthase, a C--O phenol-coupling cytochrome P450 from the higher plant Berberis stoloniferaQ34565545
A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesisQ36798017
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The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agentsQ40619566
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The taxane diterpenoidsQ44865401
The tomato Dwarf gene isolated by heterologous transposon tagging encodes the first member of a new cytochrome P450 family.Q48063804
Antitumor activity of 9(R)-dihydrotaxane analogsQ49187031
A novel taxane with improved tolerability and therapeutic activity in a panel of human tumor xenografts.Q54103156
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The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonateQ74660802
Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coliQ24669544
Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coliQ24680969
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cellsQ28200881
Total synthesis of taxolQ28237249
Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesisQ28289878
Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yewQ28300152
Enantioselective Total Synthesis of TaxolQ29305967
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIESQ29616219
Molecular cloning of a taxa-4(20),11(12)-dien-5alpha-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coliQ30837740
Taxol biosynthetic genesQ31004828
The maize Dwarf3 gene encodes a cytochrome P450-mediated early step in Gibberellin biosynthesisQ33366810
Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesisQ33857714
Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeastQ34085514
Taxol: biosynthesis, molecular genetics, and biotechnological applicationsQ34427992
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectpaclitaxelQ423762
Taxus cuspidataQ1144815
P6954online access statusopen accessQ232932
P304page(s)13595-600
P577publication date2001-11-20
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleTaxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase
P478volume98