Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast

scientific article

Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2001PNAS...98.1501S
P356DOI10.1073/PNAS.98.4.1501
P932PMC publication ID29286
P698PubMed publication ID11171980
P5875ResearchGate publication ID12158352

P2093author name stringR M Williams
R B Croteau
A Schoendorf
C D Rithner
P2860cites workTaxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coliQ24669544
Transformation of intact yeast cells treated with alkali cationsQ24672708
Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coliQ24680969
Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthaseQ28141590
Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesisQ28289878
Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yewQ28300152
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIESQ29616219
Molecular cloning of a taxa-4(20),11(12)-dien-5alpha-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coliQ30837740
Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for taxol productionQ31968365
Identification of elicitor-induced cytochrome P450s of soybean (Glycine max L.) using differential display of mRNA.Q32058706
The maize Dwarf3 gene encodes a cytochrome P450-mediated early step in Gibberellin biosynthesisQ33366810
Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesisQ33857714
A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesisQ36798017
Taxol biosynthesis: an updateQ38556559
Yeast expression of animal and plant P450s in optimized redox environmentsQ39429286
The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agentsQ40619566
Diversity and evolution of plant P450 and P450-reductasesQ41120716
A short amino-terminal segment of microsomal cytochrome P-450 functions both as an insertion signal and as a stop-transfer sequence.Q41348706
Brassinosteroids rescue the deficiency of CYP90, a cytochrome P450, controlling cell elongation and de-etiolation in Arabidopsis.Q42628760
The taxane diterpenoidsQ44865401
The tomato Dwarf gene isolated by heterologous transposon tagging encodes the first member of a new cytochrome P450 family.Q48063804
On the membrane topology of vertebrate cytochrome P-450 proteinsQ69824621
Membrane topology of mammalian cytochromes P-450 from liver endoplasmic reticulum. Determination by trypsinolysis of phenobarbital-treated microsomesQ69964641
Microsome preparation from woody plant tissuesQ71497788
The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonateQ74660802
P433issue4
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)1501-1506
P577publication date2001-02-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMolecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast
P478volume98

Reverse relations

cites work (P2860)
Q96304757A Novel Hydroxylation Step in the Taxane Biosynthetic Pathway: A New Approach to Paclitaxel Production by Synthetic Biology
Q35168750A functional genomics approach toward the understanding of secondary metabolism in plant cells
Q33983985A retrosynthetic biology approach to metabolic pathway design for therapeutic production
Q36015856Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway
Q44830263Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid
Q24651248CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice
Q38304091Changing trends in biotechnology of secondary metabolism in medicinal and aromatic plants
Q31009707Cloning, heterologous expression, and functional characterization of 5-epi-aristolochene-1,3-dihydroxylase from tobacco (Nicotiana tabacum).
Q46289692Comparative proteomic analyses of two Taxus species (Taxus × media and Taxus mairei) reveals variations in the metabolisms associated with paclitaxel and other metabolites
Q96816824Comparative transcriptome analysis of a taxol-producing endophytic fungus, Aspergillus aculeatinus Tax-6, and its mutant strain
Q24799484Conservation and diversity of gene families explored using the CODEHOP strategy in higher plants.
Q39038619Correlation analysis of the taxane core functional group modification, enzyme expression, and metabolite accumulation profiles under methyl jasmonate treatment
Q44796642Cytochrome P450 genes induced by bispyribac-sodium treatment in a multiple-herbicide-resistant biotype of Echinochloa phyllopogon.
Q30985560Cytochrome P450 oxygenases of Taxol biosynthesis
Q28741110Cytochromes p450
Q44866947Distinct roles of cinnamate 4-hydroxylase genes in Populus
Q35537845Distributing a metabolic pathway among a microbial consortium enhances production of natural products
Q37998382Downstream reactions and engineering in the microbially reconstituted pathway for Taxol
Q104752400Engineering Plant Cytochrome P450s for Enhanced Synthesis of Natural Products: Past Achievements and Future Perspectives
Q104064430Evaluation of spore inoculum and confirmation of pathway genetic blueprint of T13αH and DBAT from a Taxol-producing endophytic fungus
Q40263843Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering
Q34264230Functional Genomics of P450S
Q34600470Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells
Q36473253Genes, enzymes and chemicals of terpenoid diversity in the constitutive and induced defence of conifers against insects and pathogens
Q46308193Genome-scale modeling of yeast: chronology, applications and critical perspectives.
Q57003263Hazel and other sources of paclitaxel and related compounds
Q34244118Identification and expression analysis of methyl jasmonate responsive ESTs in paclitaxel producing Taxus cuspidata suspension culture cells
Q34494510Identification of beta-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay
Q35409519Identification of novel knockout targets for improving terpenoids biosynthesis in Saccharomyces cerevisiae
Q64275793Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis
Q24632373Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes
Q24653492Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin
Q39559784Mannitol Stress Directs Flavonoid Metabolism toward Synthesis of Flavones via Differential Regulation of Two Cytochrome P450 Monooxygenases in Coleus forskohlii
Q35600023Metabolic engineering for drug discovery and development
Q34779126Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production
Q37772396Microbial paclitaxel: advances and perspectives
Q43790511Molecular cloning and functional identification of (+)-delta-cadinene-8-hydroxylase, a cytochrome P450 mono-oxygenase (CYP706B1) of cotton sesquiterpene biosynthesis
Q35215703Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism
Q34096062Natural products version 2.0: connecting genes to molecules.
Q52643733P450s controlling metabolic bifurcations in plant terpene specialized metabolism.
Q35121951Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation
Q44264510Probing sesquiterpene hydroxylase activities in a coupled assay with terpene synthases
Q46052551Production of isoprenoid pharmaceuticals by engineered microbes
Q46110210Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens
Q31072227Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis
Q26769057Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants
Q64114707Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora
Q38656209Steroids hydroxylation catalyzed by the monooxygenase mutant 139-3 from Bacillus megaterium BM3.
Q24655561Studies on Taxol biosynthesis: preparation of taxadiene-diol and triol derivatives by deoxygenation of taxusin
Q33714360Studies on Taxol® Biosynthesis. Preparation and Tritium Labeling of Biosynthetic intermediates by Deoxygenation of a Taxadiene Tetra-acetate Obtained from Japanese Yew.
Q43642958Substrate specificity for the hydroxylation of polyoxygenated 4(20),11-taxadienes by Ginkgo cell suspension cultures
Q34194563Taxoid metabolism: Taxoid 14β-hydroxylase is a cytochrome P450-dependent monooxygenase
Q33630392Taxol biosynthesis and molecular genetics
Q37357119Taxol biosynthesis: Identification and characterization of two acetyl CoA:taxoid-O-acetyl transferases that divert pathway flux away from Taxol production
Q28200881Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells
Q24555092Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase
Q31004828Taxol biosynthetic genes
Q60693020Taxol transport in Taxus baccata cell suspension cultures
Q37543737The Arabidopsis cytochrome P450 CYP707A encodes ABA 8'-hydroxylases: key enzymes in ABA catabolism
Q32144892The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus
Q36869904The genetic manipulation of medicinal and aromatic plants
Q34975031Total synthesis of (+)-11,11'-dideoxyverticillin A
Q41525180Transcriptome Assembly and Systematic Identification of Novel Cytochrome P450s in Taxus chinensis
Q42723318Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin

Search more.