Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology

scientific article

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1994PNAS...91.5592S
P356DOI10.1073/PNAS.91.12.5592
P3181OpenCitations bibliographic resource ID1580788
P932PMC publication ID44042
P698PubMed publication ID8202532
P5875ResearchGate publication ID14995799

P50authorGraham J LieschkeQ55149847
P2093author name stringA R Dunn
D Metcalf
J Cebon
D Grail
E Stanley
G Hodgson
J A Gall
D W Maher
V Sinickas
P2860cites workNeonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogeneQ28512170
A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factorQ33559130
Molecular physiology of granulocyte-macrophage colony-stimulating factorQ34088391
Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factorQ36361789
Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genesQ36487771
Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies: influence of colony-stimulating factorsQ37645054
Hematopoietic regulators: redundancy or subtlety?Q40790177
The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promotersQ41420689
Differential inhibition by cyclosporin A reveals two pathways for activation of lymphokine synthesis in T cellsQ46462469
Inflammatory Responses to Pneumocystis carinii in Mice Selectively Depleted of Helper T LymphocytesQ46600247
Pulmonary Alveolar ProteinosisQ55980205
Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damageQ57240770
Hemopoietic responses in mice injected with purified recombinant murine GM-CSFQ68809110
Rat tracheal epithelial cells produce granulocyte/macrophage colony-stimulating factorQ68931182
Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 moleculeQ70452024
Brief report: deficiency of pulmonary surfactant protein B in congenital alveolar proteinosisQ70532435
Use of monoclonal anti-mouse immunoglobulin to detect mouse antibodiesQ71650396
A cell-surface antigen shared by B cells and Ly2+ peripheral T cellsQ72115602
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectpathologyQ7208
macrophageQ184204
hemopoiesisQ919283
P1104number of pages5
P304page(s)5592-5596
P577publication date1994-06-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleGranulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
P478volume91

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cites work (P2860)
Q4460189315-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide
Q353514955-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival
Q365438365. Mechanisms of disordered granulopoiesis in congenital neutropenia
Q37018307A (selective) history of Australian involvement in cytokine biology
Q26774775A Review of GM-CSF Therapy in Sepsis
Q38685636A Semiquantitative Computed Tomographic Grading System for Evaluating Therapeutic Response in Pulmonary Alveolar Proteinosis.
Q42007592A T Cell View of the Bone Marrow
Q101477993A cell-centric view of lung alveologenesis
Q27345215A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
Q46358328A novel 1,25-dihydroxyvitamin D-activin A pathway in human alveolar macrophages is dysfunctional in patients with pulmonary alveolar proteinosis (PAP).
Q34032594A practical approach to evaluating and treating neutropenia in the neonatal intensive care unit
Q51710520A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction.
Q28586895A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation
Q35803316A role for granulocyte-macrophage colony-stimulating factor in the regulation of CD8(+) T cell responses to rabies virus
Q53528634ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis.
Q28273478AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
Q74495523Acute respiratory failure caused by secondary alveolar proteinosis in a patient with acute myeloid leukemia: a case report
Q91260456Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury
Q30156952Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.
Q36971475Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation.
Q31157006Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection
Q35101037Alveolar proteinosis in a patient recovering from Pneumocystis carinii infection: a case report with a review of literature
Q28261260Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease
Q29615498An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
Q37418292An open-label trial of rituximab therapy in pulmonary alveolar proteinosis
Q43058950Anti-GM-CSF antibodies in paediatric pulmonary alveolar proteinosis
Q22011170Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation
Q90312369Anticytokine Autoantibodies: Association with Infection and Immune Dysregulation
Q53894176Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis.
Q37072048Autoantibody-Mediated Pulmonary Alveolar Proteinosis in Rasgrp1-Deficient Mice.
Q38049370Autoimmune pulmonary alveolar proteinosis: treatment options in year 2013.
Q24290960Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice
Q36060847Biallelic Mutations of Methionyl-tRNA Synthetase Cause a Specific Type of Pulmonary Alveolar Proteinosis Prevalent on Réunion Island
Q52604134CCL17 blockade as a therapy for osteoarthritis pain and disease.
Q57112440CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons
Q37999076CSF-1 signaling in macrophages: pleiotrophy through phosphotyrosine-based signaling pathways
Q38218871CSF-1R signaling in health and disease: a focus on the mammary gland.
Q28507518Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung
Q51093849Cell-cell signalling in the regulation of blood cell formation and function.
Q34004612Cellular therapies supplement: the role of granulocyte macrophage colony-stimulating factor and dendritic cells in regulatory T-cell homeostasis and expansion
Q28509813Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice
Q24657836Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan
Q41033271Chemotherapy and neutropenia
Q73879537Circadian rhythm of granulocyte-macrophage colony-stimulating factor in normal subjects and neutropenic hospitalised patients
Q34244200Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism
Q33680122Clinical features and outcomes of idiopathic pulmonary alveolar proteinosis in Korean population
Q36203148Clinical significance of anti-GM-CSF antibodies in idiopathic pulmonary alveolar proteinosis
Q43068695Clinical uses of GM-CSF, a critical appraisal and update
Q37190439Colony-stimulating factors in inflammation and autoimmunity.
Q28348147Comparison of macrophage responses to oxidized low-density lipoprotein and macrophage colony-stimulating factor (M-CSF or CSF-1)
Q33194891Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis
Q28138504Compound SFTPB 1549C-->GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP-B) deficiency
Q36371058Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response
Q62817943Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia
Q54576649Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation.
Q37693083Crossing paths: interactions between the cell death machinery and growth factor survival signals
Q28590729Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice
Q39360158Cytokine gene expression profile in monocytic cells after a co-culture with epithelial cells.
Q36970182Cytokine receptors and hematopoietic differentiation
Q36375400Cytokine-activated endothelial cells delay neutrophil apoptosis in vitro and in vivo. A role for granulocyte/macrophage colony-stimulating factor
Q41165211Cytokines and production of surfactant components
Q35074547Cytokines and the immune-testicular axis
Q47912530Cytokines in hematopoiesis
Q64008502Cytokines in hematopoiesis: specificity and redundancy in receptor function
Q41022590Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor beta chain (hbetac) responsible for human GM-CSF-induced myeloid cell differentiation
Q33766421Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1.
Q36377402Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor
Q61955139Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor
Q34157406Development of hammerhead ribozymes to modulate endogenous gene expression for functional studies.
Q35753538Development of secreted proteins as biotherapeutic agents
Q44773983Differential alterations in plasma colony-stimulating factor concentrations in meningococcaemia
Q34336416Differentiation, apoptosis, and function of human immature and mature myeloid cells: intracellular signaling mechanism
Q40547290Disseminated Mycobacterium kansasii infection with pulmonary alveolar proteinosis in a patient with chronic myelogenous leukemia
Q37424817Distinct progenitor origin distinguishes a lineage of dendritic-like cells in spleen
Q27002464Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets
Q37367171Distinct responses of human monocyte subsets to Aspergillus fumigatus conidia
Q37039002Dynamics of lung macrophage activation in response to helminth infection.
Q37388105Dysregulated hematopoiesis and a progressive neurological disorder induced by expression of an activated form of the human common beta chain in transgenic mice
Q53761467Effect of granulocyte-macrophage colony-stimulating factor on the number of leucocytes and course of Listeria monocytogenes infection in naive and leucocytopenic mice.
Q35782608Effects of macrophage colony-stimulating factor on macrophages and their related cell populations in the osteopetrosis mouse defective in production of functional macrophage colony-stimulating factor protein
Q36284490Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile.
Q79184205Elevated IL-10 Inhibits GM-CSF Synthesis in Pulmonary Alveolar Proteinosis
Q38206076Emergency granulopoiesis
Q34106812Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis
Q36370397Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion
Q35061752Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice
Q37118186Enhancing the clinical activity of granulocyte-macrophage colony-stimulating factor-secreting tumor cell vaccines
Q42623970Exogenous granulocyte-macrophage colony-stimulating factor administration for pulmonary alveolar proteinosis
Q36979961Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.
Q46357118Fertility impairment in granulocyte-macrophage colony-stimulating factor-deficient mice.
Q42063604FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cells
Q34359869From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Q40596439Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection
Q36022709Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation
Q30366001Functional significance of mononuclear phagocyte populations generated through adult hematopoiesis
Q37607068G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis
Q26800954G-CSF and GM-CSF in Neutropenia
Q28554454GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes
Q58698466GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function
Q30476295GM-CSF action in the CNS decreases food intake and body weight
Q30835058GM-CSF and IL-3 Modulate Human Monocyte TNF-α Production and Renewal in In Vitro Models of Trained Immunity.
Q41870391GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity
Q38369816GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential.
Q47138480GM-CSF as a therapeutic target in autoimmune diseases
Q36398839GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells
Q82224165GM-CSF deficiency delays neointima formation in a normolipidemic mouse model of endoluminal endothelial damage
Q90701013GM-CSF in inflammation
Q34754737GM-CSF in inflammation and autoimmunity.
Q43481101GM-CSF mediates alveolar macrophage proliferation and type II cell hypertrophy in SP-D gene-targeted mice
Q36916371GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival
Q42844958GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice
Q37778844GM-CSF pathway correction in pulmonary alveolar proteinosis
Q40242340GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.
Q55303373GM-CSF targeted immunomodulation affects host response to M. tuberculosis infection.
Q90265818GM-CSF-Dependent Inflammatory Pathways
Q96640469GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
Q33842816GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection
Q34058590GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen.
Q28080640GM-CSF: An immune modulatory cytokine that can suppress autoimmunity
Q42616336GM-CSF: a role in immune and inflammatory reactions in the intestine
Q95823976Gene therapy of beta(c)-deficient pulmonary alveolar proteinosis (beta(c)-PAP): studies in a murine in vivo model
Q77903163General classes and functions of four-helix bundle cytokines
Q24626239Genetic interstitial lung disease
Q40382136Genetic knockouts in mice: an update
Q28388821Genetically manipulated mouse models of lung disease: potential and pitfalls
Q35820983Granulocyte colony-stimulating factor and leukemogenesis.
Q41101389Granulocyte colony-stimulating factor and modulation of inflammatory cells in sepsis
Q73676636Granulocyte macrophage colony stimulating factor (GM-CSF) activity is regulated by a GM-CSF binding molecule in Wallerian degeneration following injury to peripheral nerve axons
Q34457373Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions
Q42944465Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis.
Q33302233Granulocyte-macrophage colony stimulating factor-mediated innate responses in tuberculosis
Q36394962Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know
Q40639060Granulocyte-macrophage colony-stimulating factor (GM-CSF) is released by female mouse bladder urothelial cells and expressed by the urothelium as an early response to lipopolysaccharides (LPS).
Q45285614Granulocyte-macrophage colony-stimulating factor and lung immunity in pulmonary alveolar proteinosis
Q33551339Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimer's disease and multiple sclerosis
Q39570156Granulocyte-macrophage colony-stimulating factor in Staphylococcus aureus-induced arthritis.
Q46929817Granulocyte-macrophage colony-stimulating factor in amniotic fluid and in airway specimens of newborn infants
Q41699299Granulocyte-macrophage colony-stimulating factor increases surfactant phospholipid in premature rabbits
Q36633120Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development.
Q42503353Granulocyte-macrophage colony-stimulating factor is essential for normal wound healing
Q43547982Granulocyte-macrophage colony-stimulating factor promotes glucose transport and blastomere viability in murine preimplantation embryos
Q34005519Granulocyte-macrophage colony-stimulating factor-deficient mice have impaired resistance to blood-stage malaria
Q36403358Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells
Q35745319Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation
Q37129681Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects
Q39242434Growth Factor Regulation in the Nephrogenic Zone of the Developing Kidney
Q41689649Growth factors and hematopoietic stem cells
Q24799022Growth factors in lung development and disease: friends or foe?
Q52538767Haemopoiesis in mice genetically lacking granulocyte-macrophage colony stimulating factor during chronic infection with Mycobacterium avium.
Q33853579Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5.
Q34734185Hematopoietic cytokines
Q41193269Hematopoietic effects and clinical application of granulopoietic growth factors
Q34402453Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy
Q34573221Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
Q42503158Human alveolar macrophages and granulocyte-macrophage colony-stimulating factor-induced monocyte-derived macrophages are resistant to H2O2 via their high basal and inducible levels of catalase activity
Q33995307Human hemato-lymphoid system mice: current use and future potential for medicine
Q28139629Human malignant osteopetrosis: pathophysiology, management and the role of bone marrow transplantation
Q24316176Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression
Q38112353IL-34 and CSF-1: similarities and differences
Q42514540IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.
Q34979530Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling
Q37771906Immune dysregulation in the pathogenesis of pulmonary alveolar proteinosis
Q43650913Immunomodulatory effects of moxifloxacin in comparison to ciprofloxacin and G-CSF in a murine model of cyclophosphamide-induced leukopenia
Q35143094Immunomodulatory effects of quinolones
Q43756046Immunotherapeutic effects of recombinant adenovirus encoding granulocyte-macrophage colony-stimulating factor in experimental pulmonary tuberculosis.
Q41429411Impact of knockout mice in toxicology
Q64110652Inflammatory Cytokine Networks in Gastrointestinal Tract Graft vs. Host Disease
Q33950106Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis
Q64255636Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease
Q38932181Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity
Q38468658Innate response activator B cells: origins and functions
Q36416397Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.
Q37377903Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.
Q36131723Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
Q37375089Is Cryptococcus gattii a Primary Pathogen?
Q34869806Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages
Q40409394Knockouts. Targeting the mouse genome: a compendium of knockouts (Part I)
Q35769439Lineage commitment and developmental plasticity in early lymphoid progenitor subsets
Q41241667Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia
Q51136551Long-term inhaled granulocyte macrophage-colony-stimulating factor in autoimmune pulmonary alveolar proteinosis: effectiveness, safety, and lowest effective dose.
Q48026318Lung disease: Treatment by cell transplant
Q37218071Lung environment determines unique phenotype of alveolar macrophages
Q26740162Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia-a new therapeutic strategy?
Q34145236Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
Q53274292MDSCs are involved in the protumorigenic potentials of GM-CSF in colitis-associated cancer.
Q35826586MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF.
Q37077690Macrophage differentiation and function in health and disease
Q37521345Macrophages and CSF-1: implications for development and beyond
Q63915886Macrophages and Cardiovascular Health
Q27007092Macrophages: gatekeepers of tissue integrity
Q40563569Management of pulmonary alveolar proteinosis by repeated bronchoalveolar lavage.
Q37315900Mast cells are required for full expression of allergen/SEB-induced skin inflammation
Q34411088Mavrilimumab: an evidence based review of its potential in the treatment of rheumatoid arthritis
Q54035383Mice unresponsive to GM-CSF are unexpectedly resistant to cutaneous Leishmania major infection.
Q55355299Microbiota and immune cell crosstalk: dialogues driving health and disease.
Q49447486Model-Based Discovery and Development of Biopharmaceuticals: A Case Study of Mavrilimumab
Q47911167Molecular and cellular events in early thymocyte development
Q41763168Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody
Q29547438Monocyte and macrophage heterogeneity
Q37726689Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death
Q58478781Mouse macrophage development in the absence of the common γ chain: defining receptor complexes responsible for IL-4 and IL-13 signaling
Q40241909Murine dendritic cell transdifferentiation into osteoclasts is differentially regulated by innate and adaptive cytokines
Q24541648Myeloid commitment shifts toward monocytopoiesis after thermal injury and sepsis
Q89876422NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS
Q89660035Natural Autoantibodies in Chronic Pulmonary Diseases
Q40922914Neutropenia in the neonate.
Q34092240Neutrophil kinetics in health and disease.
Q38310658Neutrophil migration under normal and sepsis conditions
Q38665014Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.
Q36938511Oral mucosal dendritic cells and periodontitis: many sides of the same coin with new twists
Q33908222Origins and functions of phagocytes in the embryo
Q35743143Outcome of corticosteroid administration in autoimmune pulmonary alveolar proteinosis: a retrospective cohort study
Q41526360Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies
Q36121727PPARs in alveolar macrophage biology
Q33889234PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors
Q44535674PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor
Q33988125Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates
Q44477055Peroxisome proliferator-activated receptor-gamma is deficient in alveolar macrophages from patients with alveolar proteinosis
Q37237437Pertussis toxin-sensitive G proteins regulate lymphoid lineage specification in multipotent hematopoietic progenitors
Q26830824Pivotal roles of GM-CSF in autoimmunity and inflammation
Q33703008Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
Q51713983Potential roles of extracellular signal-regulated kinase but not p38 during myeloid differentiation of U937 cells stimulated by cytokines: augmentation of differentiation via prolonged activation of extracellular signal-regulated kinase.
Q37175923Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture
Q84773120Protection against Nippostrongylus brasiliensis infection in mice is independent of GM-CSF
Q36470632Protein microarrays identify disease-specific anti-cytokine autoantibody profiles in the landscape of immunodeficiency
Q38924994Pulmonary Alveolar Proteinosis Syndrome
Q95410224Pulmonary alveolar proteinosis
Q53210676Pulmonary alveolar proteinosis as an unusual pattern of lung involvement in Sjögren syndrome.
Q36979986Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1.
Q49351201Pulmonary alveolar proteinosis in adults: pathophysiology and clinical approach
Q33774873Pulmonary alveolar proteinosis in children on La Réunion Island: a new inherited disorder?
Q43358363Pulmonary alveolar proteinosis secondary to Pneumocystis jiroveci infection in an infant with common variable immunodeficiency
Q35795061Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice
Q64123181Pulmonary alveolar proteinosis: An autoimmune disease lacking an HLA association
Q34365898Pulmonary alveolar proteinosis: a review
Q34115410Pulmonary alveolar proteinosis: an overview for internists and hospital physicians
Q24679404Pulmonary alveolar proteinosis: clinical aspects and current concepts on pathogenesis
Q38041659Pulmonary alveolar proteinosis: diagnostic and therapeutic challenges
Q34139014Pulmonary alveolar proteinosis: progress in the first 44 years
Q38416755Pulmonary alveolar proteinosis: time to shift?
Q39759848Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice
Q34539736Pulmonary macrophage transplantation therapy
Q41416064Pulmonary pharmacodynamics of an anti-GM-CSFRα antibody enables therapeutic dosing that limits exposure in the lung
Q45867818Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis
Q34660473RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.
Q37181748Rare lung disease II: pulmonary alveolar proteinosis.
Q34520707Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin
Q36449773Redefining Myeloid Cell Subsets in Murine Spleen
Q34989547Reduced number and morphofunctional change of alveolar macrophages in MafB gene-targeted mice
Q40637210Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor
Q37061451Regulation of postnatal lung development and homeostasis by estrogen receptor beta.
Q34138184Regulatory pathways in blood-forming tissue with particular reference to gap junctional communication
Q41849470Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions
Q47319432Resistance and susceptibility to tuberculosis analysed at the transcriptome level: lessons from mouse macrophages
Q43107256Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients
Q55239888Rituximab for auto-immune alveolar proteinosis, a real life cohort study.
Q42638867Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection
Q36705885Role of Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Regulating Neutrophil Antifungal Activity and the Oxidative Burst During Respiratory Fungal Challenge
Q43179240Role of granulocyte macrophage colony-stimulating factor during gram-negative lung infection with Pseudomonas aeruginosa.
Q35746087Role of granulocyte/macrophage colony-stimulating factor in zymocel-induced hepatic granuloma formation
Q42789370Role of interferon-gamma in interleukin 12-induced pathology in mice.
Q89168207Safety testing of monoclonal antibodies in non-human primates: Case studies highlighting their impact on human risk assessment
Q41399533Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts
Q24557526Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation
Q30306581Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice
Q90103848Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages
Q33943220Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family.
Q28390164Spontaneous pulmonary alveolar proteinosis in captive "moustached tamarins" (Saguinus mystax)
Q35946169Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis
Q78127510Spontaneously occurring neutralizing antibodies against granulocyte-macrophage colony-stimulating factor in patients with autoimmune disease
Q38988087Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date
Q48150411Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.
Q41672860Surfactant protein B deficiency: insights into inherited disorders of lung cell metabolism
Q35143717Susceptibility to tuberculosis: A locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs
Q38284004Systems approach to phagocyte production and activation: neutrophils and monocytes
Q36823006T cell functions in granulocyte/macrophage colony-stimulating factor deficient mice
Q42189381T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung
Q33959954Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis.
Q38657999Targeting GM-CSF in inflammatory diseases
Q41581562Targeting cholesterol homeostasis in lung diseases
Q92515207The Alveolar Lipidome in Pulmonary Alveolar Proteinosis. A New Target for Therapeutic Development?
Q34304678The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling
Q91708004The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game
Q33785115The beta common chain (beta c) of the granulocyte macrophage-colony stimulating factor, interleukin-3 and interleukin-5 receptors
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