Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM

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Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI19876
10.1172/JCI200419876
P3181OpenCitations bibliographic resource ID4758273
P932PMC publication ID484972
P698PubMed publication ID15286800

P50authorClaude KnaufQ42763449
Gavin KelseyQ48304318
Guy A. RutterQ56240272
Wendy DeanQ60975980
Isabelle LeclercQ61090112
P2093author name stringDan Ma
Julian P H Shield
R éMy Burcelin R
P2860cites workTranscriptional activation capacity of the novel PLAG family of zinc finger proteinsQ24309016
Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brainQ24309817
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequenceQ24311830
hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancerQ24317330
Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA bindingQ24540824
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreasQ24647944
The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetesQ28143868
Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitusQ28213084
Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthoodQ28217907
Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cellsQ28238567
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growthQ28508976
The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient miceQ28513142
Genomic imprinting: parental influence on the genomeQ29616227
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenumQ29618151
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitorsQ29619012
Insulin-promoter-factor 1 is required for pancreas development in miceQ29619695
Transcription of the mouse PAC1 receptor gene: cell-specific expression and regulation by Zac1.Q31062590
Pax genes and the differentiation of hormone-producing endocrine cells in the pancreasQ33855370
Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions.Q33903904
A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC.Q33913119
Perspective: Postnatal pancreatic beta cell growthQ33929597
Regulation of the pancreatic pro-endocrine gene neurogenin3.Q33945269
Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptorsQ33962326
The neuropeptide pituitary adenylate cyclase-activating polypeptide and islet functionQ34346667
Reprogramming of genome function through epigenetic inheritanceQ34426502
Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.Q34427073
Nutrient-secretion coupling in the pancreatic islet beta-cell: recent advancesQ34560782
Transient neonatal diabetes and later onset diabetes: a case of inherited insulin resistanceQ34795490
GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilizationQ34997816
Regulation of pdx-1 gene expressionQ35022138
Pancreatic cell lineage analyses in miceQ35080583
PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance.Q35159144
Aetiopathology and genetic basis of neonatal diabetesQ35285260
Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretionQ40866515
Expression of neurogenin3 reveals an islet cell precursor population in the pancreasQ40867538
Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.Q40878349
Molecular and functional characterization of pituitary adenylate cyclase-activating polypeptide (PACAP-38)/vasoactive intestinal polypeptide receptors in pancreatic beta-cells and effects of PACAP-38 on components of the insulin secretory systemQ40915252
Pancreatic development and maturation of the islet B cell. Studies of pluripotent islet culturesQ41343014
The beta cell transcription factors and development of the pancreasQ41496269
The mouse Zac1 locus: basis for imprinting and comparison with human ZAC.Q42680409
Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat dietQ43908141
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet developmentQ44055107
Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.Q44418710
A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q.Q46661066
Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sitesQ47888790
Induction of the PAC1-R (PACAP-type I receptor) gene by p53 and Zac.Q48188005
A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitusQ48561080
Temporal and quantitative correlations between insulin secretion and stably elevated or oscillatory cytoplasmic Ca2+ in mouse pancreatic beta-cells.Q52237874
Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.Q52348002
An imprinted locus associated with transient neonatal diabetes mellitusQ57261281
Regulatory factor linked to late-onset diabetes?Q58986438
Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreasQ59070691
Genome-Wide Linkage Analysis Assessing Parent-of-Origin Effects in the Inheritance of Type 2 Diabetes and BMI in Pima IndiansQ59150799
Glucose-stimulated DNA replication of the pancreatic islets during the development of the rat fetus. Effects of nutrients, growth hormone, and triiodothyronineQ69900042
Further evidence for an imprinted gene for neonatal diabetes localised to chromosome 6q22-q23Q71617593
Developmental biology of the pancreasQ71845371
An imprinted gene(s) for diabetes?Q72161192
Congenital absence of insulin cells in a neonate with diabetes mellitus and mutase-deficient methylmalonic acidaemiaQ72216746
Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoterQ73473642
Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitusQ73738916
Early-onset type-II diabetes mellitus (MODY4) linked to IPF1Q73777239
Transient neonatal diabetes: widening the understanding of the etiopathogenesis of diabetesQ74102330
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectglucoseQ37525
glycobiologyQ899224
transient neonatal diabetes mellitusQ7834286
P304page(s)339-348
P577publication date2004-08-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleImpaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM
P478volume114

Reverse relations

cites work (P2860)
Q377979616q24 transient neonatal diabetes.
Q57173336Aberrantly expressed genes and miRNAs in human hypopharyngeal squamous cell carcinoma based on RNA‑sequencing analysis
Q34442748BACs as tools for the study of genomic imprinting
Q37219834Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice
Q55277101Chromosome 6q24-related diabetes mellitus.
Q33603660Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function
Q41885314Concurrent course of transient neonatal diabetes with cholestasis and paucity of interlobular bile ducts: a case report.
Q38108670Could lncRNAs contribute to β-cell identity and its loss in Type 2 diabetes?
Q33740650Degree of methylation of ZAC1 (PLAGL1) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort
Q38086766Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes
Q37994282Diabetes mellitus and the β cell: the last ten years
Q59198124Diabètes sucrés néonatals
Q51889267Differential expression pattern of ZAC in developing mouse and human pancreas.
Q34342504Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues.
Q46706648Early onset diabetes mellitus
Q41689688Epigenetics in formation, function, and failure of the endocrine pancreas
Q42669985Further refinement of the critical minimal genetic region for the imprinting disorder 6q24 transient neonatal diabetes.
Q37004529Genetic and epigenetic defects at the 6q24 imprinted locus in a cohort of 13 patients with transient neonatal diabetes: new hypothesis raised by the finding of a unique case with hemizygotic deletion in the critical region
Q27865274Genetics and pathophysiology of neonatal diabetes mellitus
Q90319801Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion
Q91596236Genomic imprinting and its effects on postnatal growth and adult metabolism
Q30981538High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta.
Q37696626Hypoglycaemia following diabetes remission in patients with 6q24 methylation defects: expanding the clinical phenotype.
Q26829945Imprinted Zac1 in neural stem cells
Q36874343Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood.
Q92617573LncRNA TUG1 ameliorates diabetic nephropathy by inhibiting miR-21 to promote TIMP3-expression
Q39847763Long non-coding RNA ENSMUST00000147869 protects mesangial cells from proliferation and fibrosis induced by diabetic nephropathy
Q34656513Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic β cell line MIN6.
Q37015978Molecular diagnosis of maturity onset diabetes of the young in India
Q34403650Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure.
Q38406027Multitasking C2H2 zinc fingers link Zac DNA binding to coordinated regulation of p300-histone acetyltransferase activity
Q36194882Mutations in the Kir6.2 subunit of the KATP channel and permanent neonatal diabetes: new insights and new treatment
Q46625457Neonatal diabetes mellitus
Q81152665Neonatal diabetes mellitus
Q35742082Neonatal diabetes mellitus: a disease linked to multiple mechanisms
Q34037120Neonatal diabetes mellitus: a model for personalized medicine
Q33343294Neonatal diabetes: how research unravelling the genetic puzzle has both widened our understanding of pancreatic development whilst improving children's quality of life
Q43554623Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study [corrected].
Q39302029Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells
Q37097498Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt
Q56777707Pdx1- and Ngn3-Cre-Mediated PLAG1 Expression in the Pancreas Leads to Endocrine Hormone Imbalances That Affect Glucose Metabolism
Q35665947Pericentrin Is Related to Abnormal β-Cell Insulin Secretion through F-Actin Regulation in Mice
Q48162007Permanent neonatal diabetes caused by abnormalities in chromosome 6q24.
Q33883436Regulation of cardiomyocyte Glut4 expression by ZAC1
Q52085968Resourceful imprinting.
Q39172425Role of DNA methylation in imprinting disorders: an updated review
Q26795765Role of ZAC1 in transient neonatal diabetes mellitus and glucose metabolism
Q35458473Roles of imprinted genes in neural stem cells
Q57303417The diagnosis and management of monogenic diabetes in children and adolescents
Q34559930The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice
Q34426232The role of genomic imprinting in biology and disease: an expanding view
Q35295496The role of imprinted genes in fetal growth abnormalities
Q51992629Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.
Q59130141Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells
Q35902835Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia
Q35859435Transient Neonatal Diabetes Mellitus followed by recurrent asymptomatic hypoglycaemia: a case report
Q64968384Transient multifocal genomic crisis creating chromothriptic and non-chromothriptic rearrangements in prezygotic testicular germ cells.
Q39355907Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1
Q34134807Transient neonatal diabetes mellitus type 1.
Q35852352Unlocking the secrets of the pancreatic beta cell: man and mouse provide the key.
Q24301866ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome
Q42483072Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1.
Q34412930Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: differential phenotype of the Zac1-expressing cells during development