Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function

scientific article

Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.EBIOM.2017.03.040
P932PMC publication ID5405175
P698PubMed publication ID28389215

P2093author name stringYukio Tanizawa
Kaoru Yamamoto
Akihiko Taguchi
Koh Shinoda
Akie Yanai
Masaru Akiyama
Hiroko Nakabayashi
Ruriko Fujimoto
Takuro Matsumura
Yasuharu Ohta
Risa Suetomi
P2860cites workMacromolecule biosynthesis: a key function of sleepQ48459737
Uncoupling proteins and sleep deprivation.Q48576865
Imaging pancreatic beta-cells in the intact pancreas.Q50744722
The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing.Q50893716
Involvement of cAMP/EPAC/TRPM2 activation in glucose- and incretin-induced insulin secretion.Q54352998
Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndromeQ69492465
Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cellsQ79393694
Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cellsQ83103488
Rhythms in glutamine synthetase activity, energy charge, and glutamine in sunflower rootsQ83258034
Glycemic control is impaired in the evening in prediabetes through multiple diurnal rhythmsQ87891618
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)Q22003951
Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activationQ24306636
Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDMQ24562990
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetesQ24633002
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cellsQ24810302
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndromeQ28142981
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cellsQ28508342
Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in womenQ28741820
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in miceQ30435990
The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membraneQ30534507
Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.Q33420360
Gene-environment interactions in the development of type 2 diabetes: recent progress and continuing challengesQ34271415
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat dietQ34275922
Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challengesQ34451866
Islet beta cell failure in type 2 diabetesQ34698810
The GTPase Rab37 Participates in the Control of Insulin ExocytosisQ34797941
Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells.Q35180070
Convergence of the insulin and serotonin programs in the pancreatic β-cellQ35561126
Rhythms in energy storage control the ability of the cyanobacterial circadian clock to resetQ35771385
Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunctionQ35986714
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretionQ36345553
Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in miceQ36654885
Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats.Q37193371
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cellsQ40367285
Common variants in WFS1 confer risk of type 2 diabetesQ41852502
Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratioQ43762969
Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1β gene expression in pancreatic islet β-cellsQ44692437
Incidence of diabetes in middle-aged men is related to sleep disturbancesQ45081270
Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout miceQ46134848
Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motilityQ46406538
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in miceQ46649057
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosisQ46744627
P304page(s)146-156
P577publication date2017-03-30
P1433published inEBioMedicineQ24912341
P1476titleClock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function
P478volume18

Reverse relations

cites work (P2860)
Q64098109Calcium Signaling and Contractility in Cardiac Myocyte of Wolframin Deficient Rats
Q94678393Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver
Q57149243G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes
Q55180871Molecular clock as a regulator of β-cell function.
Q59794327Ursolic Acid Attenuates Hepatic Steatosis, Fibrosis, and Insulin Resistance by Modulating the Circadian Rhythm Pathway in Diet-Induced Obese Mice

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